Results 121 to 130 of about 2,689 (173)

Alkaloid metabolism in wounded Catharanthus roseus seedlings

Plant Physiology and Biochemistry, 2004
The effect of mechanical wounding on alkaloid metabolism was analyzed in Catharanthus roseus seedlings. Wounding induced an increase in ajmalicine accumulation, whereas catharanthine remained unaffected. A positive dual effect on vindoline was noticed.
Felipe, Vázquez-Flota, Mildred, Carrillo-Pech, Yereni, Minero-García, María, De Lourdes Miranda-Ham   +3 more
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Analysis of Catharanthus roseus alkaloids by HPLC

Phytochemistry Reviews, 2007
Catharanthus roseus is a medicinal plant from which secondary metabolites used in chemotherapy to treat diverse cancers are extracted. The well known high value metabolites vincristine and vinblastine are just 2 of 130 alkaloids that can be found in C. roseus.
Steve Hisiger, Mario Jolicoeur
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Alkaloid catabolism and mobilization in catharanthus roseus

Phytochemistry, 1976
Abstract The catabolic turnover of vindoline and catharanthine, indole-dihydroindole alkaloids produced by Catharanthus roseus , occurs much more rapidly in apical cuttings than in intact plants. The implication of the results is that such alkaloids may participate actively in the plant's biochemical processes under certain conditions, in ...
Peter E. Daddona, James L. Wright, C.Richard Hutchinson   +2 more
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Alkaloid production by transformed root cultures of Catharanthus roseus

Plant Cell Reports, 1988
Transformed roots of Catharanthus roseus were obtained following infection of detached leaves with Agrobacterium rhizogenes. Roots would not grow in full strength Gamborg's B5 medium but would grow satisfactorily if the medium was diluted to one half strength. Little alkaloid appeared in the growth medium but root tissue contained a high level and wide
A J, Parr, A C, Peerless, J D, Hamill, N J, Walton, R J, Robins, M J, Rhodes   +5 more
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Alkaloid Production in Catharanthus roseus Cell Cultures VIII

Planta Medica, 1981
A cell line of Catharanthus roseus (L.) G. Don coded PRL # 200, was characterized with respect to its biosynthetic capabilities for indolealkaloids, in particular catharanthine, in suspension cultures. Other alkaloids isolated are vallesiachotamine isomers, ajmalicine, hörhammericine, hörhammerinine, vindolinine, 19-epivindolinine and strictosidine ...
W G, Kurz, K B, Chatson, F, Constabel, J P, Kutney, L S, Choi, P, Kolodziejczyk, S K, Sleigh, K L, Stuart, B R, Worth   +8 more
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Engineering Catharanthus roseus monoterpenoid indole alkaloid pathway in yeast

Applied Microbiology and Biotechnology, 2022
Catharanthus roseus (Madagascar periwinkle), a medicinal plant possessing high pharmacological attributes, is widely recognized for the biosynthesis of anticancer monoterpenoid indole alkaloids (MIAs) - vinblastine and vincristine. The plant is known to biosynthesize more than 130 different bioactive MIAs, highly acclaimed in traditional and modern ...
Vyoma Mistry, Siddhi Darji, Pragya Tiwari, Abhishek Sharma   +3 more
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Cytotoxic dimeric indole alkaloids from Catharanthus roseus

Fitoterapia, 2012
Three new dimeric indole alkaloids (1-3), together with five known ones (4-8), were isolated from the whole plants of Catharanthus roseus. The structures and absolute configurations of new compounds were elucidated by means of NMR and CD analyses. All these compounds were evaluated for their in vitro cytotoxic activities against human breast cancer ...
Chun-Hua, Wang, Guo-Cai, Wang, Ying, Wang, Xiao-Qi, Zhang, Xiao-Jun, Huang, Dong-Mei, Zhang, Min-Feng, Chen, Wen-Cai, Ye   +7 more
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The iridoid pathway in Catharanthus roseus alkaloid biosynthesis

Phytochemistry Reviews, 2007
The Apocynaceae Catharanthus roseus accumulates a number of monoterpene indole alkaloids (MIAs) that originate from the coupling of the indole and the iridoid pathways. The latter pathway is usually considered as limiting for MIA biosynthesis, but evidence is now strong that the precursors tryptamine (from the indole pathway) and secologanin (from the ...
Audrey Oudin, Martine Courtois, Marc Rideau, Marc Clastre   +3 more
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Indole Alkaloids from the Roots of Catharanthus roseus

Chemistry of Natural Compounds, 2014
Catharanthus roseus (L.) G. Don is a well-known traditional herbal medicine, which is rich in indole alkaloids [1]. The chemical constituents of C. roseus have been investigated in our group [2, 3], and our further research has led to nine indole alkaloids (1–9) from the roots of C. roseus.
Chun-Hua Wang, Yu Zhang, Miao-Miao Jiang
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Vincazalidine A, a unique bisindole alkaloid from Catharanthus roseus

Journal of Natural Medicines
A new dimeric indole alkaloid, vincazalidine A consisting of an aspidosperma type and a modified iboga type with 1-azatricyclo ring system consisting of one azepane and two piperidine rings coupled with an oxazolidine ring was isolated from Catharanthus roseus, and the structure including absolute stereochemistry was elucidated on the basis of ...
Yusuke, Hirasawa, Ayaka, Kase, Akie, Okamoto, Keigo, Suzuki, Mizuki, Hiroki, Toshio, Kaneda, Nahoko, Uchiyama, Hiroshi, Morita   +7 more
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