Results 61 to 70 of about 2,691 (173)

Virus‐Induced Gene Silencing in Calendula officinalis (Pot Marigold)

Plant Direct, Volume 10, Issue 5, May 2026.
ABSTRACT Virus‐induced gene silencing (VIGS) is a method that exploits plant antiviral defense mechanisms to downregulate endogenous genes. The technique is versatile, rapid, and widely used for functional genomics studies. Here, we report a method for VIGS in the medicinal plant, Calendula officinalis (pot marigold).
Daria Cuthbert, Connor Tansley, Melissa Salmon, Nicola Patron   +3 more
wiley   +1 more source

Mass Spectrometry Imaging Combined With Single‐Cell Transcriptional Profiling Reveals the Multidimensional Spatial Distributions and Biosynthetic Pathways of Medicinal Components in Andrographis paniculata

Plant Biotechnology Journal, Volume 24, Issue 5, Page 2876-2890, May 2026.
ABSTRACT The synthesis and accumulation of active ingredients in medicinal plants are distributed in specific organs, tissues, and cell types, which are important for the exploitation of medicinal plants. However, the fine distribution of active ingredients is difficult to know. Here, the system of mass spectrometry imaging (MSI) integrated with single‐
HaiSheng Zeng, MeiHui Shi, ZhiRong Chen, XueJing Sun, HuiJie Zhang, Yue Huang, YuCheng Chen, Jun Ren, HuiLing Huang, Almaz Borjigidai, Man Zhang, SuJuan Duan, Yi‐Jun Chen, Hong‐Lei Jin, Hong‐Bin Wang   +14 more
wiley   +1 more source

Xanthatin Targets CISD1 to Drive Ferroptosis and Mitophagy as a Dual Anticancer Strategy in Triple‐Negative Breast Cancer

Advanced Science, Volume 13, Issue 21, 13 April 2026.
Triple‐negative breast cancer has a poor prognosis. Xanthatin directly targets and degrades CISD1, triggering ferroptosis through iron dysregulation. The concurrently activated mitophagy synergistically amplifies ferroptotic cell death. Xanthatin also demonstrates potent in vivo anti‐tumor efficacy with minimal toxicity, highlighting its therapeutic ...
Qinwen Liu, Haojie Chen, Xiang Li, Jingxin Liu, Yiwen Li, Zhenyi Shi, Shenshen Guo, Qingfeng Du, Aiping Lu, Daogang Guan   +9 more
wiley   +1 more source

Molecular validation of genetically transformed Catharanthus roseus plants via different strains of Agrobacterium tumefaciens

Heliyon
Medical plants play a crucial role in the pharmaceutical industry due to their natural synthesis of active compounds. Synthetic methods exist, which provide fewer effective molecules compared to those naturally occurring.
Rania El-Tanbouly, Hend Hassan, Lojina M. Awd, Azza Ali Makhlouf, Hani G. Shalabi, Sarah El-Messeiry   +5 more
doaj   +1 more source

Tabernaemontana catharinensis: A Source of Indole Alkaloids With Potential Activity as Chemotherapeutic Agents

Chemistry &Biodiversity, Volume 23, Issue 4, April 2026.
ABSTRACT This study aimed to evaluate the antitumor activity of fractions rich in indole alkaloids extracted from the leaves of the species Tabernaemontana catharinensis. The chemical composition was analyzed using high‐resolution mass spectrometry (HRMS), which identified nine known indole alkaloids, including voacangine, voacangine hydroxyindolenine,
Ana Júlia Gomes Donada, Rafael Freitas Corá, Bianca Canci, Mariana Roesch‐Ely, Pauline Fagundes Rosales, Sidnei Moura   +5 more
wiley   +1 more source

Cathagines A–D, new bisindole alkaloids from Catharanthus roseus

Journal of Natural Medicines
Four new bisindole alkaloids, cathagines A (1)-D (4) consisting of an aspidosperma and the fused tetracyclic 3-spirooxindole derived from an iboga type skeleton were isolated from the whole plant of Catharanthus roseus. The structures including absolute stereochemistry were elucidated on the basis of 2D NMR data and CD spectra.
Yusuke, Hirasawa, Chiaki, Kasagi, Erika, Koyama, Hitomi, Myojin, Takahiro, Tougan, Toshihiro, Horii, Nahoko, Uchiyama, Toshio, Kaneda, Hiroshi, Morita   +8 more
openaire   +2 more sources

Effect of Aspergillus flavus Fungal Elicitor on the Production of Terpenoid Indole Alkaloids in Catharanthus roseus Cambial Meristematic Cells

Molecules, 2018
This study reported the inducing effect of Aspergillus flavus fungal elicitor on biosynthesis of terpenoid indole alkaloids (TIAs) in Catharanthus roseus cambial meristematic cells (CMCs) and its inducing mechanism. According to the results determined by
Chuxin Liang, Chang Chen, Pengfei Zhou, Lv Xu, Jianhua Zhu, Jincai Liang, Jiachen Zi, Rongmin Yu   +7 more
doaj   +1 more source

Effects of PEG-induced drought stress on regulation of indole alkaloid biosynthesis in Catharanthus roseus

Journal of Plant Interactions, 2017
Catharanthus roseus (C. roseus) plants were used to investigate the terpenoid indole alkaloids (TIAs) accumulation under the condition of PEG-induced drought stress.
Ying Liu, Qinghuan Meng, Xihua Duan, Zhonghua Zhang, Dewen Li   +4 more
doaj   +1 more source

Enzymology of indole alkaloid biosynthesis in Catharanthus roseus.

Indian journal of biochemistry & biophysics, 1997
Indole alkaloids in Catharanthus roseus have been in focus because of their medicinal value. These alkaloids consist of an indole moiety provided by tryptamine and a terpenoid portion provided by the secologanin. The most important catharanthus alkaloids are vinblastine (VLB), vincristine (VCR) and ajmalicine.
N, Misra, R, Luthra, S, Kumar
openaire   +1 more source

Effect of Catharanthus mosaic virus (CatMV) on antineoplastic alkaloids from periwinkle (Catharanthus roseus L.) cultured in Mecca region and resistance induction by plant growth-promoting rhizobacteria

Biotechnology & Biotechnological Equipment, 2019
Periwinkle (Catharanthus roseus L.) grown in the Mecca region contains more than 100 alkaloids such as vincristine and vinblastine used to treat leukaemia.
Hassan Mobark Al-Zahrany, Esam Kamal Fahmi Elbeshehy, Amal Yahya Aldhebiani, Omar Almaghrabi, Abdullah Abdulhafith Al-Jaddawi, Anas Hassan Alzahrani   +5 more
doaj   +1 more source