Results 51 to 60 of about 2,689 (173)

Virus‐Induced Gene Silencing in Calendula officinalis (Pot Marigold)

Plant Direct, Volume 10, Issue 5, May 2026.
ABSTRACT Virus‐induced gene silencing (VIGS) is a method that exploits plant antiviral defense mechanisms to downregulate endogenous genes. The technique is versatile, rapid, and widely used for functional genomics studies. Here, we report a method for VIGS in the medicinal plant, Calendula officinalis (pot marigold).
Daria Cuthbert, Connor Tansley, Melissa Salmon, Nicola Patron   +3 more
wiley   +1 more source

Gas Chromatography-Mass Spectrometry (GC-MS) Analysis of Indole Alkaloids Isolated from Catharanthus roseus (L.) G. Don Cultivated Conventionally and Derived from In vitro Cultures

Notulae Botanicae Horti Agrobotanici Cluj-Napoca, 2016
Catharanthus roseus (periwinkle) is a medicinal plant commonly known for its wide biological activity. In many countries different parts of this plant are used for the treatment of diabetes, hypertension and for menstrual regulation.
Aneta WESOŁOWSKA, Janusz WILAS, Monika GRZESZCZUK, Danuta KULPA   +3 more
doaj   +1 more source

Mass Spectrometry Imaging Combined With Single‐Cell Transcriptional Profiling Reveals the Multidimensional Spatial Distributions and Biosynthetic Pathways of Medicinal Components in Andrographis paniculata

Plant Biotechnology Journal, Volume 24, Issue 5, Page 2876-2890, May 2026.
ABSTRACT The synthesis and accumulation of active ingredients in medicinal plants are distributed in specific organs, tissues, and cell types, which are important for the exploitation of medicinal plants. However, the fine distribution of active ingredients is difficult to know. Here, the system of mass spectrometry imaging (MSI) integrated with single‐
HaiSheng Zeng, MeiHui Shi, ZhiRong Chen, XueJing Sun, HuiJie Zhang, Yue Huang, YuCheng Chen, Jun Ren, HuiLing Huang, Almaz Borjigidai, Man Zhang, SuJuan Duan, Yi‐Jun Chen, Hong‐Lei Jin, Hong‐Bin Wang   +14 more
wiley   +1 more source

Unveiling the Promise of Bioactive Alkaloid Compound from Catharanthus Roseys: An In-vitro Computational Exploration of their Molecular Docking against a Target Protein for Type-2 Diabetes [PDF]

Journal of Clinical and Diagnostic Research
Introduction: Molecular docking facilitates the exploration of interactions between bioactive alkaloid compounds and target proteins, offering insights into potential binding modes and affinity, crucial for drug discovery and understanding molecular ...
A Mariappan, PK Jabir, D Alfred Solomon, Shyamaladevi Babu, Madhan Krishnan   +4 more
doaj   +1 more source

Xanthatin Targets CISD1 to Drive Ferroptosis and Mitophagy as a Dual Anticancer Strategy in Triple‐Negative Breast Cancer

Advanced Science, Volume 13, Issue 21, 13 April 2026.
Triple‐negative breast cancer has a poor prognosis. Xanthatin directly targets and degrades CISD1, triggering ferroptosis through iron dysregulation. The concurrently activated mitophagy synergistically amplifies ferroptotic cell death. Xanthatin also demonstrates potent in vivo anti‐tumor efficacy with minimal toxicity, highlighting its therapeutic ...
Qinwen Liu, Haojie Chen, Xiang Li, Jingxin Liu, Yiwen Li, Zhenyi Shi, Shenshen Guo, Qingfeng Du, Aiping Lu, Daogang Guan   +9 more
wiley   +1 more source

Tabernaemontana catharinensis: A Source of Indole Alkaloids With Potential Activity as Chemotherapeutic Agents

Chemistry &Biodiversity, Volume 23, Issue 4, April 2026.
ABSTRACT This study aimed to evaluate the antitumor activity of fractions rich in indole alkaloids extracted from the leaves of the species Tabernaemontana catharinensis. The chemical composition was analyzed using high‐resolution mass spectrometry (HRMS), which identified nine known indole alkaloids, including voacangine, voacangine hydroxyindolenine,
Ana Júlia Gomes Donada, Rafael Freitas Corá, Bianca Canci, Mariana Roesch‐Ely, Pauline Fagundes Rosales, Sidnei Moura   +5 more
wiley   +1 more source

Modulatory Effects of Cirsimarin on Lung Cancer A549 Cells Migration in 2D and 3D Cultures Involves Transcriptional Regulation of Metalloproteinases

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 3, March 2026.
In 2D culture, the cirsimarin (i) decreased cell viability in both assays, (ii) induced apoptosis, (iii) reduced clonogenicity, (iv) prevented cell migration, (v) induced DNA damage, and (vi) negatively modulated gene expression. In the 3D model, reductions in spheroid viability, area, and cell migration were also observed.
Anna Gabriele Prado dos Santos, Celina Yung‐Ai Lin Lee, Érica Romão Pereira, Andresa Hiromi Sakai, Diego Luís Ribeiro, Victor Antônio Silva Lima, Marcos Bispo Pinheiro Camara, Cláudia Quintino da Rocha, Sabine A. S. Langie, Ilce Mara de Syllos Cólus, Juliana Mara Serpeloni   +10 more
wiley   +1 more source

CrMPK3, a mitogen activated protein kinase from Catharanthus roseus and its possible role in stress induced biosynthesis of monoterpenoid indole alkaloids

BMC Plant Biology, 2012
Background Mitogen activated protein kinase (MAPK) cascade is an important signaling cascade that operates in stress signal transduction in plants. The biologically active monoterpenoid indole alkaloids (MIA) produced in Catharanthus roseus are known to ...
Raina Susheel, Wankhede Dhammaprakash, Jaggi Monika, Singh Pallavi, Jalmi Siddhi, Raghuram Badmi, Sheikh Arsheed, Sinha Alok   +7 more
doaj   +1 more source

Progress in NMR-based metabolomics of Catharanthus roseus [PDF]

Frontiers of Agricultural Science and Engineering, 2015
Metabolomics has been rapidly developed as an important field in plant sciences and natural products chemistry. As the only natural source for a diversity of monoterpenoid indole alkaloids (MIAs), especially the low-abundance antitumor agents vinblastine
Qifang PAN,Jingya ZHAO,Yuliang WANG,Kexuan TANG
doaj   +1 more source

Green Synthesis of Metal Oxide Nanoparticles Using Plant Extracts: Applications in Catalysis and Biomedicine

Nano Select, Volume 7, Issue 3, March 2026.
ABSTRACT The green synthesis of metal oxide nanoparticles (MONPs) using plant‐based resources has gained significant traction as an environmentally benign, cost‐effective, and scalable alternative to traditional chemical and physical methods. This review comprehensively explores the plant‐mediated synthesis routes for a variety of MONPs, including CuO,
Faith Mwangi, Jannatun Zia, Ufana Riaz
wiley   +1 more source