Results 31 to 40 of about 6,749 (214)

Cloning and Overexpression of Strictosidine β-D-Glucosidase Gene Short Sequence from Catharanthus roseus in Escherichia coli [PDF]

Advanced Pharmaceutical Bulletin, 2019
Purpose: Strictosidine-β-D-glucosidase (SGD) is considered as a key enzyme in the production of bisindole alkaloids in Catharanthus roseus. The present study illustrated the production of a short sequence of this enzyme in Escherichia coli without codon ...
Ahmed Saeed Arafa, Amany Elsayed Ragab, Abdel-Rahim Sayed Ibrahim, Wael Saad Abdel-Mageed, Mahmoud Emam Nasr   +4 more
doaj   +1 more source

Artemisinic Acid Serves as a Novel Inducer to Enhance Biosynthesis of Terpenoid Indole Alkaloids in Cambial Meristematic Cells

Natural Product Communications, 2016
To investigate the effect of artemisinic acid (AA) on improving the production of terpenoid indole alkaloids (TIAs) of Catharanthus roseus cambial meristematic cells (CMCs), feeding AA to C.
Mingxuan Wang, Jiachen Zi, Jianhua Zhu, Shan Chen, Pu Wang, Liyan Song, Rongmin Yu   +6 more
doaj   +1 more source

Binary Stress Induces an Increase in Indole Alkaloid Biosynthesis in Catharanthus roseus

Frontiers in Plant Science, 2015
Catharanthus roseus is an important medicinal plant, which produces a variety of indole alkaloids of significant pharmaceutical relevance. In the present study, we aimed to investigate the potential stress-induced increase of indole alkaloid biosynthesis
Wei eZhu, Bingxian eYang, Setsuko eKomatsu, Xiaoping eLu, Ximin eLi, Jingkui eTian   +5 more
doaj   +1 more source

Strictosidine activation in Apocynaceae: towards a "nuclear time bomb"? [PDF]

, 2010
Background The first two enzymatic steps of monoterpene indole alkaloid (MIA) biosynthetic pathway are catalysed by strictosidine synthase (STR) that condensates tryptamine and secologanin to form strictosidine and by strictosidine β-D-glucosidase (SGD ...
Guirimand Grégory, Courdavault Vincent, Lanoue Arnaud, Mahroug Samira, Guihur Anthony, Blanc Nathalie, Giglioli-Guivarc'h Nathalie, St-Pierre Benoit, Burlat Vincent   +8 more
core   +1 more source

The Cadin-2-en-1β-ol-1β-d-glucuronopyranoside Suppresses TPA-Mediated Matrix Metalloproteinase-9 Expression Through the ERK Signaling Pathway in MCF-7 Human Breast Adenocarcinoma Cells

Journal of Pharmacological Sciences, 2012
A sesquiterpene glycoside, cadin-2-en-1β-ol-1β-D-glucuronopyranoside (known as CR4-1), was isolated from Catharanthus roseus (Apocynaceae) hairy root cultures. C. roseus is widely used as an ornamental and medicinal plant and is cultivated mainly for its
Jung-Hee Kim, Man Sub Kim, Yesol Bak, Ill-Min Chung, Do-Young Yoon   +4 more
doaj   +1 more source

In Silico Evaluation of Pharmacokinetics and Toxicity Profile of AlkaloidsPresent in Leaves of Catharanthus roseus L.

RGUHS Journal of Pharmaceutical Sciences
Background Catharanthus roseus Madagascar periwinkle is a well-known medicinal plant that produces a variety of alkaloids with significant pharmacological activities particularly in cancer and diabetes treatment.Aim This study aimed ...
Ramgopal M Dhanwad, Usha R, Ganesh S
doaj   +1 more source

De Novo transcriptome assembly and differential expression analysis of catharanthus roseus in response to salicylic acid

Scientific Reports, 2022
The anti-cancer vinblastine and vincristine alkaloids can only be naturally found in periwinkle (Catharanthus roseus). Both of these alkaloids' accumulations are known to be influenced by salicylic acid (SA).
Narges Soltani, Farhad Nazarian Firouzabadi, Alireza Shafeinia, Masoud Shirali, Ayeh Sadat Sadr   +4 more
doaj   +1 more source

Do Fungicides Affect Alkaloid Production in Catharanthus roseus (L.) G. Don. Seedlings?

Molecules, 2023
The presence of endophytes in plants is undeniable, but how significant their involvement is in the host plant biosynthetic pathways is still unclear. The results reported from fungicide treatments in plants varied. Fungicide treatment in Taxus was found
Purin Candra Purnama, Leonardo Castellanos Hernandez, Robert Verpoorte   +2 more
doaj   +1 more source

Application of recombinant DNA technology to studies on plant secondary metabolism [PDF]

, 2001
This review which is concerned with the application of recombinant DNA technology to studies on plant secondary metabolism, presents the more common plant transformation strategies and shows how these genetic approaches are being used in attempts to ...
Yeoman, Michael M., Zárate, Rafael
core   +1 more source

Overexpression of ORCA3 and G10H in Catharanthus roseus plants regulated alkaloid biosynthesis and metabolism revealed by NMR-metabolomics. [PDF]

PLoS ONE, 2012
In order to improve the production of the anticancer dimeric indole alkaloids in Catharanthuse roseus, much research has been dedicated to culturing cell lines, hairy roots, and efforts to elucidate the regulation of the monoterpenoid indole alkaloid ...
Qifang Pan, Quan Wang, Fang Yuan, Shihai Xing, Jingya Zhao, Young Hae Choi, Robert Verpoorte, Yuesheng Tian, Guofeng Wang, Kexuan Tang   +9 more
doaj   +1 more source