Results 11 to 20 of about 6,749 (214)

CrERF5, an AP2/ERF Transcription Factor, Positively Regulates the Biosynthesis of Bisindole Alkaloids and Their Precursors in Catharanthus roseus

Frontiers in Plant Science, 2019
Catharanthus roseus contains a variety of monoterpenoid indole alkaloids (MIAs), among which bisindole alkaloids vinblastine and vincristine are well-known to have antitumor effects and widely used in clinical treatment.
Qifang Pan, Chenyi Wang, Zhiwei Xiong, Hang Wang, Xueqing Fu, Qian Shen, Bowen Peng, Yanan Ma, Xiaofen Sun, Kexuan Tang   +9 more
doaj   +3 more sources

Antidiabetic and Antioxidant Properties of Alkaloids from Catharanthus roseus (L.) G. Don

Molecules, 2013
Catharanthus roseus (L.) G. Don is a herbal plant traditionally used by local populations in India, South Africa, China and Malaysia to treat diabetes. The present study reports the in vitro antioxidant and antidiabetic activities of the major alkaloids ...
Won Fen Wong, Shiau-Chuen Cheah, Mohd Rais Mustafa, Mohammadjavad Paydar, Aditya Arya, Soon Huat Tiong, Chung Yeng Looi, Khalijah Awang, Hazrina Hazni   +8 more
doaj   +3 more sources

Radiolytically degraded sodium alginate enhances plant growth, physiological activities and alkaloids production in Catharanthus roseus L.

Journal of Radiation Research and Applied Sciences, 2015
Catharanthus roseus (L.) G. Don (Family Apocynaceae) is a medicinal plant that produces indole alkaloids used in cancer chemotherapy. The anticancerous alkaloids, viz. vinblastine and vincristine, are mainly present in the leaves of C. roseus.
M. Naeem, Tariq Aftab, Abid A. Ansari, Mohd Idrees, Akbar Ali, M. Masroor A. Khan, Moin Uddin, Lalit Varshney   +7 more
doaj   +3 more sources

Indole Alkaloids from Catharanthus roseus: Bioproduction and Their Effect on Human Health

Molecules, 2015
Catharanthus roseus is a medicinal plant belonging to the family Apocynaceae which produces terpenoid indole alkaloids (TIAs) of high medicinal importance.
Lorena Almagro, Francisco Fernández-Pérez, Maria Angeles Pedreño   +2 more
doaj   +3 more sources

A cell-type-specific regulon controlling monoterpene indole alkaloid biosynthesis with feedback and feedforward activation loops. [PDF]

New Phytol
Summary Monoterpene indole alkaloids (MIA) are a diverse class of plant natural products produced by a subset of lineages within the Asterid clade of eudicots. The diversity of MIAs provides a unique opportunity to study not only the evolution of biosynthetic genes but also their regulation.
Li C, Wood JC, Vaillancourt B, Hamilton JP, Jones SL, Bui VH, Dang TT, Buell CR.   +7 more
europepmc   +2 more sources

Combined Transcriptomic and Metabolomic Analysis Reveals an Ethylene-Activated Regulatory Model on Monoterpenoid Indole Alkaloid Biosynthesis in Catharanthus roseus. [PDF]

Plant Biotechnol J
ABSTRACT Catharanthus roseus contains nearly 200 bioactive monoterpenoid indole alkaloids (MIAs) that are effective in treating cancer and other diseases. Ethylene plays a significant role in enhancing MIA biosynthesis, and we have found that it greatly induces the accumulation of anhydrovinblastine.
Deng B, Miao Q, Ou C, Pan Y, Liu H, Fu X, Li L, Wang Y, Tang K, Pan Q.   +9 more
europepmc   +2 more sources

Confirmation of “pre-plasmolysis mediated ex-osmosis hypothesis” to obtain shoot bud morphogenesis in Catharanthus roseus

Journal of Genetic Engineering and Biotechnology, 2021
The antineoplastic herb, Catharanthus roseus is a classified high-value low-volume medicinal herb which is in global attention of scientific research for modulation of its monoterpenoid indole alkaloids (MIA) pathway through genetic engineering.
Vyoma Mistry, Abhishek Sharma, Ajay Kumar Mathur   +2 more
doaj   +1 more source

Enhancement of Vindoline and Catharanthine Accumulation, Antioxidant Enzymes Activities, and Gene Expression Levels in Catharanthus roseus Leaves by Chitooligosaccharides Elicitation

Marine Drugs, 2022
Catharanthus roseus (L.) G. Don is a plant belonging to the genus Catharanthus of the Apocynaceae family. It contains more than one hundred alkaloids, of which some exhibit significant pharmacological activities.
Wenzhu Tang, Xiaoqi Liu, Yuning He, Fan Yang   +3 more
doaj   +1 more source

Alkaloide aus Catharanthus roseus-Zellkulturen, III [1] / Alkaloids from Catharanthus roseus Tissue Cultures, III [1]

Zeitschrift für Naturforschung B, 1981
Abstract From the methanol extract of Catharanthus roseus tissue cultures sitsirikine (2), isositsirikine (3), dihydrositsirikine (4), yohimbine (5), 3-iso-19-epiajmalicine (6), pleio-carpamine (7), antirhin (8) and two up to now unknown alkaloids have been isolated in addition to the compounds previously found in the hexane extract ...
Werner Kohl, Barbara Witte, Gerhard Höfle   +2 more
openaire   +1 more source

Anti-hyperlipidemic and anti-diabetic evaluation of ethanolic leaf extract of Catharanthus roseus alone and in combination therapy

Brazilian Journal of Pharmaceutical Sciences, 2022
The use of plants in disease treatment is cost effective and relatively safe. This study was designed to investigate anti-hyperlipidemic and anti-diabetic activity of ethanolic leaf extract of Catharanthus roseus alone and in combination therapy in ...
Khadija Azam, Muhammad Adil Rasheed, Muhammad Ovais Omer, Imran Altaf, Amina Akhlaq   +4 more
doaj   +1 more source