Results 11 to 20 of about 2,689 (173)

Discovery of a Plant Pictet-Spenglerase With R-Stereoselectivity. [PDF]

Angew Chem Int Ed Engl
Strictosidine synthases (STRs) are plant Pictet–Spenglerases catalyzing the coupling of a secoiridoid with tryptamine. All previously characterized strictosidine synthases are strictly S‐selective. Here, we report the discovery of Epi‐STR, an R‐selective STR ortholog from the medicinal plant Pogonopus speciosus.
Morweiser C, Heinicke S, O'Connor SE, Colinas M.   +3 more
europepmc   +3 more sources

Potentiating Biosynthesis of Alkaloids and Polyphenolic Substances in Catharanthus roseus Plant Using ĸ-Carrageenan

Molecules, 2023
Catharanthus roseus is a medicinal plant that produces indole alkaloids, which are utilized in anticancer therapy. Vinblastine and vincristine, two commercially important antineoplastic alkaloids, are mostly found in the leaves of Catharanthus roseus.
Hossam S. El-Beltagi, Salwa M. El-Sayed, Ahmed. N. Abdelhamid, Karim. M. Hassan, Walaa. A. Elshalakany, Mona Ibrahim Nossier, Nadiyah M. Alabdallah, Nadi Awad Al-Harbi, Salem Mesfir Al-Qahtani, Doaa Bahaa Eldin Darwish, Zahid Khorshid Abbas, Hemmat A. Ibrahim   +11 more
doaj   +1 more source

Exploration of the Mechanisms of Differential Indole Alkaloid Biosynthesis in Dedifferentiated and Cambial Meristematic Cells of Catharanthus roseus Using Transcriptome Sequencing

Frontiers in Genetics, 2022
Catharanthus roseus produces terpenoid indole alkaloids (TIAs) of high medicinal importance. The current research focuses on finding an efficient production system such as cell suspension cultures for high TIA concentrations.
Pengfei Zhou, Mingxiang Chen
doaj   +1 more source

A Catharanthus roseus Fe(II)/α-ketoglutarate-dependent dioxygenase catalyzes a redox-neutral reaction responsible for vindolinine biosynthesis

Nature Communications, 2022
Catharanthus roseus is the source for anticancer drug vinblastine and other medicinal monoterpenoid indole alkaloids. Here the authors characterize an Fe/2OG dioxygenase, vindolinine synthase, which catalyzes an unusual redox-neutral reaction leading to ...
Jasmine Ga May Eng, Mohammadamin Shahsavarani, Daniel Patrick Smith, Josef Hájíček, Vincenzo De Luca, Yang Qu   +5 more
doaj   +1 more source

Confirmation of “pre-plasmolysis mediated ex-osmosis hypothesis” to obtain shoot bud morphogenesis in Catharanthus roseus

Journal of Genetic Engineering and Biotechnology, 2021
The antineoplastic herb, Catharanthus roseus is a classified high-value low-volume medicinal herb which is in global attention of scientific research for modulation of its monoterpenoid indole alkaloids (MIA) pathway through genetic engineering.
Vyoma Mistry, Abhishek Sharma, Ajay Kumar Mathur   +2 more
doaj   +1 more source

Enhancement of Vindoline and Catharanthine Accumulation, Antioxidant Enzymes Activities, and Gene Expression Levels in Catharanthus roseus Leaves by Chitooligosaccharides Elicitation

Marine Drugs, 2022
Catharanthus roseus (L.) G. Don is a plant belonging to the genus Catharanthus of the Apocynaceae family. It contains more than one hundred alkaloids, of which some exhibit significant pharmacological activities.
Wenzhu Tang, Xiaoqi Liu, Yuning He, Fan Yang   +3 more
doaj   +1 more source

Development of a Cell Suspension Culture System for Promoting Alkaloid and Vinca Alkaloid Biosynthesis Using Endophytic Fungi Isolated from Local Catharanthus roseus

Plants, 2021
Cell and tissue cultures of Catharanthus roseus have been studied extensively as an alternative strategy to improve the production of valuable secondary metabolites. The purpose of this study was to produce C. roseus callus and suspension cell biomass of
Tran My Linh, Nguyen Chi Mai, Pham Thi Hoe, Ninh Thi Ngoc, Phan Thi Hong Thao, Ninh Khac Ban, Nguyen Tuong Van   +6 more
doaj   +1 more source

Anti-hyperlipidemic and anti-diabetic evaluation of ethanolic leaf extract of Catharanthus roseus alone and in combination therapy

Brazilian Journal of Pharmaceutical Sciences, 2022
The use of plants in disease treatment is cost effective and relatively safe. This study was designed to investigate anti-hyperlipidemic and anti-diabetic activity of ethanolic leaf extract of Catharanthus roseus alone and in combination therapy in ...
Khadija Azam, Muhammad Adil Rasheed, Muhammad Ovais Omer, Imran Altaf, Amina Akhlaq   +4 more
doaj   +1 more source

Ajmalicine Bioproduction in Catharanthus Roseus (L) G. Don Inoculated with Arbuscular Mycorrhiza and Fertilized with Nitrogen

Revista Brasileira de Ciência do Solo, 2018
Catharanthus roseus (L) G. Don (Madagascar periwinkle) belongs to the Apocynaceace family and is widely spread throughout tropical and subtropical regions of the world.
Cecília Silva Monnerat, Marta Simone Mendonça Freitas, Ivo José Curcino Vieira, Marco Antônio Martins, Almy Junior Cordeiro de Carvalho, Paulo Cesar dos Santos, Thaísa Capato Lima   +6 more
doaj   +1 more source

A Novel AP2/ERF Transcription Factor CR1 Regulates the Accumulation of Vindoline and Serpentine in Catharanthus roseus

Frontiers in Plant Science, 2017
As one type of the most important alkaloids in the world, terpenoid indole alkaloids (TIAs) show a wide range of pharmaceutical activities that are beneficial for clinical treatments.
Jiaqi Liu, Fangyuan Gao, Juansheng Ren, Xianjun Lu, Guangjun Ren, Rui Wang   +5 more
doaj   +1 more source