Results 1 to 10 of about 6,749 (214)

Monoterpenoid Indole Alkaloids from Cultivated in Yunnan [PDF]

Natural Product Communications, 2015
A new monoterpenoid indole alkaloid, 15,20-dehydro-3α-(2-oxopropyl) coronaridine (1) , along with sixteen analogues (2–17) were isolated from the leaves of Catharanthus roseus cultivated in Yunnan.
Bei Wang, Lu Liu, Ying-Ying Chen, Qiong Li, Dan Li, Ya-Ping Liu, Xiao-Dong Luo   +6 more
doaj   +3 more sources

Enhanced accumulation of anticancer compounds in C. roseus hairy root cultures through elicitation and precursor feeding [PDF]

Scientific Reports
Catharanthus roseus is a medicinal plant known for producing numerous indole terpenoid alkaloids. This study investigated the effects of methyl jasmonate, yeast extract, tryptophan, and tryptamine on the accumulation of four key alkaloids—ajmalicine ...
Mohamed R. Rady, Dalia M. Mabrouk, Mona M. Ibrahim   +2 more
doaj   +2 more sources

Pharmacological potential of bioactive compounds in Catharanthus roseus extract: A comprehensive review [PDF]

Toxicology Reports
The pharmacological potential of bioactive compounds found in the plant, Catharanthus roseus, have diverse medicinal applications. Key constituents such as vinblastine and vincristine play an important role in cancer therapy due to their ability to ...
Keren Celestina Mendonce, Naveen Palani, Suriyaprakash Rajadesingu, K. Radhakrishnan, Manikandan Ayyar, L. Srimathi Priya   +5 more
doaj   +2 more sources

Phenotypic Variability and Anticancer Alkaloid Profiles of Catharanthus roseus Cultivars Grown Under a Vertical Farming System [PDF]

Plants
Plants are promising biofactories for high-value compounds, and integrating vertical farming (VF) with plant molecular farming (PMF) enhances the efficiency and sustainability of these systems.
Marisa S. C. Lourenço, Victor Freitas, Ep Heuvelink, Susana M. P. Carvalho   +3 more
doaj   +2 more sources

HPLC-ESI-HRMS/MS-Based Metabolite Profiling and Bioactivity Assessment of Catharanthus roseus [PDF]

Plants
A comprehensive metabolic profiling of Catharanthus roseus (L.) G. Don was performed using tandem mass spectrometry, along with an evaluation of the biological activities of its various solvent extracts. Among these, the methanolic leaf extract exhibited
Soniya Joshi, Chen Huo, Rabin Budhathoki, Anita Gurung, Salyan Bhattarai, Khaga Raj Sharma, Ki Hyun Kim, Niranjan Parajuli   +7 more
doaj   +2 more sources

Catharanthus roseus intoxication mimicking acute cholangitis [PDF]

BMC Complementary Medicine and Therapies
Background Catharanthus roseus, a Madagascar native flowering plant, is known for its glossy leaves and vibrant flowers, and its medicinal significance due to its alkaloid compounds.
Yoen Young Chuah, Yeong Yeh Lee, Chu-Kuang Chou, Li-Jen Chang   +3 more
doaj   +2 more sources

Molecular validation of genetically transformed Catharanthus roseus plants via different strains of Agrobacterium tumefaciens [PDF]

Heliyon
Medical plants play a crucial role in the pharmaceutical industry due to their natural synthesis of active compounds. Synthetic methods exist, which provide fewer effective molecules compared to those naturally occurring.
Rania El-Tanbouly, Hend Hassan, Lojina M. Awd, Azza Ali Makhlouf, Hani G. Shalabi, Sarah El-Messeiry   +5 more
doaj   +2 more sources

Potentiating Biosynthesis of Alkaloids and Polyphenolic Substances in Catharanthus roseus Plant Using ĸ-Carrageenan

Molecules, 2023
Catharanthus roseus is a medicinal plant that produces indole alkaloids, which are utilized in anticancer therapy. Vinblastine and vincristine, two commercially important antineoplastic alkaloids, are mostly found in the leaves of Catharanthus roseus.
Hossam S. El-Beltagi, Salwa M. El-Sayed, Ahmed. N. Abdelhamid, Karim. M. Hassan, Walaa. A. Elshalakany, Mona Ibrahim Nossier, Nadiyah M. Alabdallah, Nadi Awad Al-Harbi, Salem Mesfir Al-Qahtani, Doaa Bahaa Eldin Darwish, Zahid Khorshid Abbas, Hemmat A. Ibrahim   +11 more
doaj   +1 more source

Exploration of the Mechanisms of Differential Indole Alkaloid Biosynthesis in Dedifferentiated and Cambial Meristematic Cells of Catharanthus roseus Using Transcriptome Sequencing

Frontiers in Genetics, 2022
Catharanthus roseus produces terpenoid indole alkaloids (TIAs) of high medicinal importance. The current research focuses on finding an efficient production system such as cell suspension cultures for high TIA concentrations.
Pengfei Zhou, Mingxiang Chen
doaj   +1 more source

A Catharanthus roseus Fe(II)/α-ketoglutarate-dependent dioxygenase catalyzes a redox-neutral reaction responsible for vindolinine biosynthesis

Nature Communications, 2022
Catharanthus roseus is the source for anticancer drug vinblastine and other medicinal monoterpenoid indole alkaloids. Here the authors characterize an Fe/2OG dioxygenase, vindolinine synthase, which catalyzes an unusual redox-neutral reaction leading to ...
Jasmine Ga May Eng, Mohammadamin Shahsavarani, Daniel Patrick Smith, Josef Hájíček, Vincenzo De Luca, Yang Qu   +5 more
doaj   +1 more source