Results 11 to 20 of about 24,668 (220)

Cathelicidins: Immunomodulatory Antimicrobials [PDF]

Vaccines, 2018
Cathelicidins are host defense peptides with antimicrobial and immunomodulatory functions. These effector molecules of the innate immune system of many vertebrates are diverse in their amino acid sequence but share physicochemical characteristics like positive charge and amphipathicity.
Roel M. Van Harten, Esther Van Woudenbergh, Albert Van Dijk, Henk P. Haagsman   +3 more
openaire   +5 more sources

The dysregulation of innate immunity by Porphyromonas gingivalis in the etiology of Alzheimer's disease. [PDF]

J Intern Med
Abstract The etiology of Alzheimer's disease (AD) remains under active debate. In this perspective, we explore the hypothesis that a primarily infection‐caused chronic dysregulation and weakening of human innate immunity via the underexpression, degradation, and inactivation of innate immune proteins necessary for direct antimicrobial effects and ...
Barron AE, Lin JS, Ryder MI, Bergman P.
europepmc   +2 more sources

Antiviral Potential of Cathelicidins [PDF]

Future Microbiology, 2013
 The global burden of morbidity and mortality arising from viral infections is high; however, the development of effective therapeutics has been slow. As our understanding of innate immunity has expanded over recent years, knowledge of natural host defenses against viral infections has started to offer potential for novel therapeutic strategies.
Barlow, Peter G., Findlay, E.G., Currie, S.M., Davidson, D.J.   +3 more
openaire   +4 more sources

Cathelicidin, vitamin D3 dan imunitas terhadap tuberkulosis

JKS (Jurnal Kedokteran Syiah Kuala), 2020
Abstrak. Tuberkulosis (TB) merupakan salah satu penyakit infeksi yang menjadi masalah di dunia. Risiko untuk mendapatkan infeksi TB dipengaruhi oleh imunitas alamiah melawan mikobakteria.
Yunita Arliny, Maryatun Hasan
doaj   +1 more source

Immunomodulatory effects of chicken cathelicidin-2 on a primary hepatic cell co-culture model

PLoS ONE, 2022
Cathelicidin-2 is an antimicrobial peptide (AMP) produced as part of the innate immune system of chickens and might be a new candidate to combat infection and inflammation within the gut-liver axis.
Csilla Sebők, Stephanie Walmsley, Patrik Tráj, Máté Mackei, Júlia Vörösházi, Janka Petrilla, László Kovács, Ágnes Kemény, Zsuzsanna Neogrády, Gábor Mátis   +9 more
doaj   +2 more sources

Cathelicidins In Humans And Animals [PDF]

Postępy Mikrobiologii - Advancements of Microbiology, 2019
Abstract Cathelicidins are Important immunological peptides – HDPs (Host Defense Peptides) with high biological activity in mammals, including human and vertebrate animals. These evolutionary ancient molecules in these organisms are natural elements of antimicrobial, antiviral, antifungal and antiparasitic immunity against which germs
Deptuła, Jakub, Tokarz-Deptuła, Beata, Malinowska-Borysiak, Magdalena, Stosik, Michał, Deptuła, Wiesław   +4 more
openaire   +2 more sources

Entamoeba histolytica Induces Intestinal Cathelicidins but Is Resistant to Cathelicidin-Mediated Killing [PDF]

Infection and Immunity, 2012
ABSTRACTThe enteric protozoan parasiteEntamoeba histolyticais the cause of potentially fatal amebic colitis and liver abscesses.E. histolyticatrophozoites colonize the colon, where they induce inflammation, penetrate the mucosa, and disrupt the host immune system. The early establishment ofE.
Eduardo R, Cobo, Chen, He, Ken, Hirata, Grace, Hwang, UyenPhuong, Tran, Lars, Eckmann, Richard L, Gallo, Sharon L, Reed   +7 more
openaire   +2 more sources

Cathelicidins Modulate TLR-Activation and Inflammation [PDF]

Frontiers in Immunology, 2020
Cathelicidins are short cationic peptides that are part of the innate immune system. At first, these peptides were studied mostly for their direct antimicrobial killing capacity, but nowadays they are more and more appreciated for their immunomodulatory functions.
Maaike R. Scheenstra, Roel M. van Harten, Edwin J. A. Veldhuizen, Henk P. Haagsman, Maarten Coorens, Maarten Coorens   +5 more
openaire   +5 more sources

Circulating Cathelicidin Concentrations in a Cohort of Healthy Children: Influence of Age, Body Composition, Gender and Vitamin D Status. [PDF]

PLoS ONE, 2016
Cathelicidin is an antimicrobial peptide whose circulating levels are related to vitamin D status in adults. This study sought to determine if circulating cathelicidin concentrations in healthy children are related to the age of the child, body ...
Taylor M Stukes, Judith R Shary, Wei Wei, Myla D Ebeling, Kaleena B Dezsi, Frank S Shary, Nina E Forestieri, Bruce W Hollis, Carol L Wagner   +8 more
doaj   +1 more source

Dodecapeptide Cathelicidins of Cetartiodactyla: Structure, Mechanism of Antimicrobial Action, and Synergistic Interaction With Other Cathelicidins [PDF]

Frontiers in Microbiology, 2021
In this study, dodecapeptide cathelicidins were shown to be widespread antimicrobial peptides among the Cetruminantia clade. In particular, we investigated the dodecapeptide from the domestic goat Capra hircus, designated as ChDode and its unique ortholog from the sperm whale Physeter catodon (PcDode).
Ilia A. Bolosov, Pavel V. Panteleev, Pavel V. Panteleev, Sergei V. Sychev, Stanislav V. Sukhanov, Pavel A. Mironov, Pavel A. Mironov, Mikhail Yu. Myshkin, Zakhar O. Shenkarev, Zakhar O. Shenkarev, Tatiana V. Ovchinnikova, Tatiana V. Ovchinnikova, Tatiana V. Ovchinnikova   +12 more
openaire   +3 more sources