Results 101 to 110 of about 16,226 (208)

Redefining the Skin Barrier: A Microbiome‐Integrated Multilayered Defense Model

Barrier Immunity, Volume 1, Issue 1, Page 27-44, December 2025.
ABSTRACT The skin constitutes a dynamic interface orchestrating a sophisticated multilayered defense system comprising physical, chemical, immune, and microbial barriers. This review synthesizes current understanding of the structural and functional integration of these barriers, emphasizing their synergistic interactions in maintaining cutaneous ...
Jingjing Xia, Mathias Hochgerner, Qingzhen Wei, Xian'ge Zhong, Jiucun Wang   +4 more
wiley   +1 more source

A Novel Pathway of Platelet Activation in ACS Mediated by LL-37 Immunoglobulin G Autoantibody Immune Complexes

JACC: Basic to Translational Science
Summary: The cathelicidin antimicrobial peptide LL-37 is a self-antigen in neutrophil extracellular traps that provokes autoantibody responses in autoimmune/autoinflammatory conditions.
Paul C. Dimayuga, PhD, Kuang-Yuh Chyu, MD, PhD, Xiaoning Zhao, PhD, Jianchang Zhou, PhD, Nicole Wai Man Lio, BS, Fernando Chernomordik, MD, Daniel Berman, MD, Prediman K. Shah, MD, Bojan Cercek, MD, PhD   +8 more
doaj   +1 more source

LL-37 boosts immunosuppressive function of placenta-derived mesenchymal stromal cells [PDF]

, 2016
Background: Although promising for graft-versus-host disease (GvHD) treatment, MSC therapy still faces important challenges. For instance, increasing MSC migratory capacity as well as potentializing immune response suppression are of interest.
Araujo, Felipe Saldanha de, Bravo, Martha Oliveira, Carvalho, Juliana Lott, Covas, Dimas Tadeu, Franco, Octávio Luiz, Neves, Francisco de Assis Rocha, Panepucci, Rodrigo Alexandre, Pereira, Rinaldo Wellerson, Sangiorgi, Bruno Braga, Schiavinato, Josiane Lilian dos Santos   +9 more
core   +1 more source

LL‐37 Inhibits TMPRSS2‐Mediated S2' Site Cleavage and SARS‐CoV‐2 Infection but Not Omicron Variants

Cell Proliferation, Volume 58, Issue 12, December 2025.
Cathelicidin LL‐37 inhibits SARS‐CoV‐2 by blocking the catalytic activity of TMPRSS2. The N764K mutation in the spike S2 subunit of Omicron variants confers resistance to LL‐37‐induced inhibition of TMPRSS2‐mediated S2' priming. ABSTRACT Continual evolution of SARS‐CoV‐2 spike drives the emergence of Omicron variants that show increased spreading and ...
Zhenfei Bi, Wenyan Ren, Hao Zeng, Yuanyuan Zhou, Jian Liu, Zimin Chen, Xindan Zhang, Xuemei He, Guangwen Lu, Yuquan Wei, Xiawei Wei   +10 more
wiley   +1 more source

The potential for immunoglobulins and host defense peptides (HDPs) to reduce the use of antibiotics in animal production [PDF]

, 2018
Innate defense mechanisms are aimed at quickly containing and removing infectious microorganisms and involve local stromal and immune cell activation, neutrophil recruitment and activation and the induction of host defense peptides (defensins and ...
A Al-Mamun, A Calmette, A Dijk van, A Dijk van, A Gronberg, A Kalita, A Lihme, A Nijnik, AH Achtman, AL Hilchie, Albert van Dijk, AM Does van der, AS Ferreira, B Rivas-Santiago, BA Blok, BS Graham, C Subbalakshmi, CD Fjell, Chris J. Hedegaard, CJ Hedegaard, CJ Hedegaard, CJ Hedegaard, CSF Bah, D Carlander, D Torrallardona, D Yang, D Yang, DA O’Neil, DA O’Neil, DC Speksnijder, DJ Davidson, DM Bowdish, DM Weaver, E Miraglia, E Tourneur, F Nimmerjahn, G Marano, G Vidarsson, H Liu, H Sherman, Henk P. Haagsman, I Nagaoka, J Kindrachuk, J Kleinnijenhuis, J Kovacs-Nolan, J Kovacs-Nolan, J Kovacs-Nolan, J Rohrl, J Schauber, JB Schaal, JD Heilborn, JH Es van, JL Pierce, K Chakraborty, K Chakraborty, K Moor, K Putsep, L Bandholtz, L Kannan, L Steinstraesser, L Zhang, LT Sunkara, M Akdis, M Cappelletti, M Coorens, M Coorens, M Ohno, M Ren, M Schlee, M Schlee, M Schwab, MA Hamon, MA Keller, MD Kraaij, MG Netea, MJ Alam, MM Rahman, N Mookherjee, N Mookherjee, NH Salzman, NY Yount, OE Sorensen, P Fehlbaum, P Presicce, P Sarker, P Tewary, Peter M. H. Heegaard, R Fisher, R Nocerino, R Ramos, R Raqib, RA Dorschner, RE Hancock, RE Hancock, RE Hancock, RI Lehrer, RJ Arts, RL Gallo, RL Hassfurther, RP Darveau, RS Rekha, S Caro Di, S Godden, S Saeed, SH Kim, T Cuperus, T Cuperus, TA Pham, TJ Newby, U Gerstel, V Petrov, V Virdi, VA Schneider, VK Lishko, W Jiang, WL Hurley, X Qiu, X Zeng, Y Goto   +118 more
core   +2 more sources

Evaluation of the effect of an extract of Sphingomonas xenophaga present in a Thermal Spring Water in the management of sensitive skin associated with cutaneous vascular disorder

International Journal of Cosmetic Science, Volume 47, Issue 6, Page 1017-1025, December 2025.
Inhibition of the kallikrein‐kinin system is a potential approach to the dermocosmetic treatment of skin disorders associated with redness. We showed that a cream formulation with a Sphingomonas ferment extract inhibiting this system was effective in improving vascular disorder after repeated application in female volunteers with sensitive and reactive
Pascal Hilaire, Carine Ballihaut, Celine Cornillon, Mark Donovan, Cosima Dufour‐Schroif, Delphine Kerob, Jean‐Jacques Schoonjans, Anna Veriato   +7 more
wiley   +1 more source

Antimicrobial peptide LL-37 ameliorates a murine sepsis model via the induction of microvesicle release from neutrophils

Innate Immunity, 2020
Sepsis is a life-threatening disease caused by systemic dys-regulated inflammatory response to infection. We previously revealed that LL-37, a human cathelicidin antimicrobial peptide, improves the survival of cecal ligation and puncture septic mice ...
Yumi Kumagai, Taisuke Murakami, Kuwahara-Arai, Toshiaki Iba, Johannes Reich, Isao Nagaoka   +5 more
doaj   +1 more source

Endogenous cathelicidin production limits inflammation and protective immunity to Mycobacterium avium in mice [PDF]

, 2013
The production of antimicrobial peptides, such as the cathelicidins, plays a prominent role in the innate immune response against microbial pathogens. Cathelicidins are widely distributed amongst living organisms, and the antimicrobial peptides generated
Appelberg, R., Gallo, R. L., Gama, F. M., Rosa, G., Santos, J. C., Silva, João P., Silva-Gomes, S.   +6 more
core   +1 more source

Breaking barriers: The cGAS‐STING pathway as a novel frontier in cancer immunotherapy

Cancer Communications, Volume 45, Issue 11, Page 1513-1546, November 2025.
Abstract Since its discovery, the cyclic GMP‐AMP synthase (cGAS)‐stimulator of the interferon gene (STING) signaling pathway has been considered a pivotal component of innate immunity and a promising target for cancer immunotherapy. Beyond its canonical role in pathogen defense, accumulating evidence has demonstrated that the cGAS‐STING pathway ...
Yuheng Yan, Ximin Tan, Bin Song, Ming Yi, Qian Chu, Kongming Wu   +5 more
wiley   +1 more source

Natural Antimicrobial Peptides: Pleiotropic Molecules in Host Defense [PDF]

, 2013
Natural antimicrobial peptides (AMPs) are small cationic molecules that display antimicrobial activity against a wide range of bacteria, fungi and viruses.
Maffia, Paulo Cesar, Martínez, Melina María Belén, Sanchez, Mercedes Leonor   +2 more
core   +1 more source