Cell ReportsSummary: The human cathelicidin peptide LL-37 induces autophagy in human macrophages. Different post-translational modifications (PTMs) such as citrullination, acetylation, and formylation impact LL-37, yet their effect on autophagy remains unknown. Thus,
Rokeya Sultana Rekha +8 more
doaj +1 more source
Escherichia coli expression and purification of LL37 fused to a family III carbohydrate-binding module from Clostridium thermocellum [PDF]
, 2010 The cathelicidin derived human peptide LL37 has a broad spectrum of antimicrobial and immunomodulatory activities. The large variety of biological activities makes LL37 a very promising candidate for clinical applications.
Domingues, Lucília +2 more
core +1 more source
Role of antimicrobial peptides in tuberculosis and respiratory tract infections : clinical and mechanistic studies [PDF]
, 2015 Antimicrobial peptides (AMPs) are effector molecules of the innate immune system in multicellular organisms. They are mainly expressed in epithelial cells and immune cells, providing the first line of defense against a wide range of pathogens.
Rekha, Rokeya Sultana
core +1 more source
Bicarbonate Resensitization of Methicillin-Resistant Staphylococcus aureus to β-Lactam Antibiotics. [PDF]
, 2019 Endovascular infections caused by methicillin-resistant Staphylococcus aureus (MRSA) are a major health care concern, especially infective endocarditis (IE).
Abdelhady, Wessam +5 more
core
A Paradigm of Translational Medicine [PDF]
, 2012 Antimicrobial peptides (AMPs) are small, cationic, amphiphilic peptides with broad-spectrum microbicidal activity against both bacteria and fungi. In mammals, AMPs form the first line of host defense against infections and generally play an important ...
Korting, H. C. +3 more
core +1 more source
Cathelicidin LL-37: LPS-neutralizing, pleiotropic peptide.
Annals of agricultural and environmental medicine : AAEM, 2007 Human organism, constantly exposed to a large variety of pathogenic microorganisms and their products, such as lipopolysaccharide (LPS), developed innate immunity as a first line of defence. One of the compartments of our organism well equipped with these defence mechanisms is the respiratory system. The cells lining the airways respond to the presence
openaire +2 more sources
PLoS ONE, 2014 Apart from their role in the immune defence against pathogens evidence of a role of antimicrobial peptides (AMPs) in autoimmune diseases has accumulated in the past years.
D Kienhöfer +13 more
doaj +1 more source
Cathelicidin peptide LL-37: A multifunctional peptide involved in heart disease
Pharmacological ResearchHeart disease is a common human disease with high morbidity and mortality. Timely and effective prevention and treatment is an urgent clinical problem. The pathogenesis of heart disease is complex and diverse, involving hypertension, diabetes, atherosclerosis, drug toxicity, thrombosis, infection and other aspects. LL-37, an endogenous peptide, is well
Shuo Miao +7 more
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Nafcillin Augmentation of Daptomycin and Cathelicidin LL-37 Killing of Methicillin-resistant Staphylococcus epidermidis: Foundations of Successful Therapy of Endocarditis. [PDF]
Int J Antimicrob Agents, 2023 Catteau L +6 more
europepmc +1 more source
Human Cathelicidin CAP18/LL-37 Changes Mast Cell Function toward Innate Immunity
Biological and Pharmaceutical Bulletin, 2008 The antimicrobial peptide LL-37 is generated from skin keratinocytes during infection of Gram-negative bacteria and exerts a microbicidal effect. LL-37 also causes functional changes in mast cells. Mast cells in the skin are involved in the innate immune system response against microbial infections via Toll-like receptors (TLRs), such as TLR4, which ...
Mino, Yoshioka +10 more
openaire +3 more sources