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Journal of Periodontology, 2009 Background: Cathelicidin LL-37, an antimicrobial peptide, is part of the host innate immune response in the oral cavity. Interleukin (IL)-18, a proinflammatory cytokine, could play a role in the progression of the inflammatory response.
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Antibiofilm properties of cathelicidin LL-37: an in-depth review
World Journal of Microbiology and Biotechnology, 2023Notwithstanding ceaseless endeavors toward developing effective antibiofilm chemotherapeutics, biofilm-associated infections continue to be one of the most perplexing challenges confronting medicine today. Endogenous host defense peptides, such as the human cathelicidin LL-37, are being propounded as promising options for treating such infectious ...
Hamed Memariani, Mojtaba Memariani
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Low Serum Levels of Cathelicidin LL-37 in Leprosy
Acta Tropica, 2011The antimicrobial peptide cathelicidin LL-37 possesses antituberculous activity, its association with other mycobacterial diseases, such as leprosy, is unknown. We studied serum cathelicidin and 25OH-vitamin D3 levels in 29 leprosy patients and 19 healthy individuals from Yemen.
Stefan Winkler +2 more
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Cathelicidin LL-37: A Multitask Antimicrobial Peptide
Archivum Immunologiae et Therapiae Experimentalis, 2010The antimicrobial peptide LL-37 is the only known member of the cathelicidin family of peptides expressed in humans. LL-37 is a multifunctional host defense molecule essential for normal immune responses to infection and tissue injury. LL-37 peptide is a potent killer of different microorganisms with the ability to prevent immunostimulatory effects of ...
Robert Bucki +3 more
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Cathelicidin LL-37 Expression in Human Breast Implant Capsules
Plastic & Reconstructive Surgery, 2023Background: Capsular contracture is the most common complication following breast implant placement. Cathelicidin LL-37 is a cationic peptide involved in innate immunity. Initially investigated for its antimicrobial role, it was found to have pleiotropic activities, such as immunomodulation, angiogenesis stimulation, and tissue
Francesco, Segreto +9 more
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A Comprehensive Summary of LL-37, the Factotum Human Cathelicidin Peptide
Cellular Immunology, 2012Cathelicidins are a group of antimicrobial peptides. Since their discovery, it has become clear that they are an exceptional class of peptides, with some members having pleiotropic effects. Not only do they possess an antibacterial, antifungal and antiviral function, they also show a chemotactic and immunostimulatory/-modulatory effect.
Liliane Schoofs +2 more
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The LL-37 domain: A clue to cathelicidin immunomodulatory response?
Peptides, 2023Host defense peptides (HDPs) are naturally occurring polypeptide sequences that, in addition to being active against bacteria, fungi, viruses, and other parasites, may stimulate immunomodulatory responses. Cathelicidins, a family of HDPs, are produced by diverse animal species, such as mammals, fish, birds, amphibians, and reptiles, to protect them ...
Michel Lopes, Leite +4 more
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Human Cathelicidin LL-37 Prevents Bacterial Biofilm Formation
Future Medicinal Chemistry, 2012Human pathogens often colonize their host by the formation of biofilms. These surface-attached aggregates of bacteria are characterized by a self-produced extracellular matrix, which makes them highly resistant towards antibiotic treatment. Their abilities to adhere to abiotic surfaces (e.g., catheters and other medical devices) also makes bacterial ...
Skovgård Jacobsen , Andreas +1 more
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LL-37: Cathelicidin-related antimicrobial peptide with pleiotropic activity
Pharmacological Reports, 2016Antimicrobial peptides (AMPs) is a large family of compounds serving as natural antibiotics, widely distributed across the organism, mainly in mucus layers. They are designed to prevent pathogens from colonization. Among them, defensins and cathelicidins could be found.
Adam, Fabisiak +2 more
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