Results 171 to 180 of about 52,950,106 (199)

Effects of the cathelicidin LL-37 on intestinal epithelial barrier integrity

Regulatory Peptides, 2009
The human cathelicidin LL-37 is involved in innate immune responses, angiogenesis and wound healing. Functions in maintenance and re-establishment of intestinal barrier integrity have not been characterized yet. Following direct and indirect stimulation of human colonic HT-29 and Caco-2 cells with LL-37 the cellular viability, rate of apoptosis ...
Jan-Michel, Otte, Anna-Elisabeth, Zdebik, Stephan, Brand, Ansgar M, Chromik, Sarah, Strauss, Frank, Schmitz, Lars, Steinstraesser, Wolfgang E, Schmidt   +7 more
openaire   +2 more sources

137
Expression of Cathelicidin (LL-37) in Thermal Injury

Wound Repair and Regeneration, 2008
Sepsis remains a common and serious complication of major burn injury and currently accounts for over 54% of deaths in burn patients. Burns have been associated with high levels of circulating proinflammatory cytokines and immunosuppression which promotes systemic inflammatory response syndrome (SIRS) and sepsis, for which no effective treatment is ...
S. Bhat, R.J. Bick, B.J. Poindexter, L.M. Buja, S.M. Milner   +4 more
openaire   +1 more source

Recombinant expression of human cathelicidin (hCAP18/LL-37) in Pichia pastoris

Biotechnology Letters, 2006
The constitutive expression of human cathelicidin LL-37 antimicrobial peptide was achieved using the methylotrophic yeast, Pichia pastoris. An LL-37 cDNA clone was amplified by PCR using human fetal cDNA library as template. The 111 bp fragment encoding mature LL-37 gene was subcloned into pGAPZ-E, an episomal form of the pGAPZB vector incorporating ...
In-Pyo, Hong, Sung-Jae, Lee, Yong-Seok, Kim, Shin-Geon, Choi   +3 more
openaire   +2 more sources

Study of cathelicidin (LL-37) immunoexpression in the skin of vitiligo patients

Archives of Dermatological Research
Vitiligo is a pigmentary disorder acquired and caused by the loss or destruction of melanocytes from the epidermis. There is strong proof that vitiligo is mainly an autoimmune disease. Cathelicidin (LL37), an antimicrobial polypeptide, is an important part of the innate immune system and has a role in different skin autoimmune diseases.
Lamia Hamouda, Elgarhy, Basma Ramadan Refaey, Ramadan, Fersan Abd Allah, Sallam, Dalya Ayman, Iskandarani, El-Sayed Shaaban, Hewedy   +4 more
openaire   +2 more sources

Serum levels of peptide cathelicidin LL-37 in elderly patients with depression

Psychiatry Research, 2017
Cathelicidin LL-37 is a small cationic that plays an important role in antimicrobial defense, as it kills a broad spectrum of infectious agents by disrupting their membranes, including gram-positive and gram-negative bacteria, some viruses and fungi; and it neutralizes activity of bacterial endotoxins.
Elżbieta, Kozłowska, Adam, Wysokiński, Ewa, Brzezińska-Błaszczyk   +2 more
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The roles of cathelicidin LL-37 in immune defences and novel clinical applications

Current Opinion in Hematology, 2009
LL-37 is the only member of the cathelicidin family of host defence peptides expressed in humans. It is primarily produced by phagocytic leucocytes and epithelial cells, and mediates a wide range of biological responses: direct killing of microorganisms, chemotaxis and chemokine induction, regulation of inflammatory responses, as well as adjuvant ...
Anastasia, Nijnik, Robert E W, Hancock
openaire   +2 more sources

Design of Antimicrobial Peptides: Progress Made with Human Cathelicidin LL-37

2019
The incorporation of the innate immune system into humans is essential for survival and health due to the rapid replication of invading microbes and the delayed action of the adaptive immune system. Antimicrobial peptides are important components of human innate immunity. Over 100 such peptides have been identified in various human tissues.
Guangshun, Wang, Jayaram Lakshmaiah, Narayana, Biswajit, Mishra, Yingxia, Zhang, Fangyu, Wang, Chunfeng, Wang, D, Zarena, Tamara, Lushnikova, Xiuqing, Wang   +8 more
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Cathelicidin LL‐37: a defense molecule with a potential role in psoriasis pathogenesis

Experimental Dermatology, 2012
Abstract:  Epidermal keratinocytes produce and secrete antimicrobial peptides (AMPs) that subsequently form a chemical shield on the skin surface. Cathelicidins are one family of AMPs in skin with various further immune functions. Consequently, dysfunction of these peptides has been implicated in the pathogenesis of inflammatory skin disease.
Dombrowski, Yvonne, Schauber, Jürgen
openaire   +3 more sources

Histone-deacetylase inhibitors induce the cathelicidin LL-37 in gastrointestinal cells

Molecular Immunology, 2004
Histone-deacetylase (HDAC) -inhibitors enhance acetylation of core proteins and this is linked to formation of transcriptionally active chromatin in various cells. In this study, the effect of HDAC inhibitors (butyrate, trichostatin A (TSA)) on the expression of the cathelicidin LL-37 in colon, gastric and hepatocellular cells was investigated.LL-37 ...
Jürgen, Schauber, Konrad, Iffland, Susanne, Frisch, Theodor, Kudlich, Bernd, Schmausser, Matthias, Eck, Thomas, Menzel, Andrea, Gostner, Hardi, Lührs, Wolfgang, Scheppach   +9 more
openaire   +2 more sources

Human cathelicidin LL-37 rapidly disrupted colonic epithelial integrity

Biochimica et Biophysica Acta (BBA) - Biomembranes
The intestinal barrier, held together by epithelial cells and intercellular tight junction (TJ) proteins, prevents the penetration of microbial pathogens. Concurrently, intestinal epithelial cells secrete antimicrobial peptides, including cathelicidin. Cathelicidin has direct antibacterial and immunomodulatory functions, although its role in intestinal
Geeta, Kilari, Jacquelyn, Tran, Graham A D, Blyth, Eduardo R, Cobo   +3 more
openaire   +2 more sources