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Antibiofilm properties of cathelicidin LL-37: an in-depth review
World Journal of Microbiology and Biotechnology, 2023Notwithstanding ceaseless endeavors toward developing effective antibiofilm chemotherapeutics, biofilm-associated infections continue to be one of the most perplexing challenges confronting medicine today. Endogenous host defense peptides, such as the human cathelicidin LL-37, are being propounded as promising options for treating such infectious ...
Hamed Memariani, Mojtaba Memariani
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LL-37: Cathelicidin-related antimicrobial peptide with pleiotropic activity
Pharmacological Reports, 2016Antimicrobial peptides (AMPs) is a large family of compounds serving as natural antibiotics, widely distributed across the organism, mainly in mucus layers. They are designed to prevent pathogens from colonization. Among them, defensins and cathelicidins could be found.
Adam Fabisiak, Jakub Fichna
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Human Cathelicidin LL-37 Prevents Bacterial Biofilm Formation
Future Medicinal Chemistry, 2012Human pathogens often colonize their host by the formation of biofilms. These surface-attached aggregates of bacteria are characterized by a self-produced extracellular matrix, which makes them highly resistant towards antibiotic treatment. Their abilities to adhere to abiotic surfaces (e.g., catheters and other medical devices) also makes bacterial ...
Andreas S, Jacobsen, Håvard, Jenssen
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Design of Antimicrobial Peptides: Progress Made with Human Cathelicidin LL-37
Advances in Experimental Medicine and Biology, 2019The incorporation of the innate immune system into humans is essential for survival and health due to the rapid replication of invading microbes and the delayed action of the adaptive immune system. Antimicrobial peptides are important components of human innate immunity. Over 100 such peptides have been identified in various human tissues.
Guangshun Wang +2 more
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Low serum levels of cathelicidin LL-37 in leprosy
Acta Tropica, 2011The antimicrobial peptide cathelicidin LL-37 possesses antituberculous activity, its association with other mycobacterial diseases, such as leprosy, is unknown. We studied serum cathelicidin and 25OH-vitamin D3 levels in 29 leprosy patients and 19 healthy individuals from Yemen.
Michael, Matzner +7 more
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A comprehensive summary of LL-37, the factotum human cathelicidin peptide
Cellular Immunology, 2012Cathelicidins are a group of antimicrobial peptides. Since their discovery, it has become clear that they are an exceptional class of peptides, with some members having pleiotropic effects. Not only do they possess an antibacterial, antifungal and antiviral function, they also show a chemotactic and immunostimulatory/-modulatory effect.
Bart Landuyt +2 more
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The LL-37 domain: A clue to cathelicidin immunomodulatory response?
Peptides, 2023Host defense peptides (HDPs) are naturally occurring polypeptide sequences that, in addition to being active against bacteria, fungi, viruses, and other parasites, may stimulate immunomodulatory responses. Cathelicidins, a family of HDPs, are produced by diverse animal species, such as mammals, fish, birds, amphibians, and reptiles, to protect them ...
Michel Lopes, Leite +4 more
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Antifungal properties of cathelicidin LL-37: current knowledge and future research directions
World Journal of Microbiology and Biotechnology, 2023The threat of fungal diseases is substantially underestimated worldwide, but they have serious consequences for humans, animals, and plants. Given the limited number of existing antifungal drugs together with the emergence of drug-resistant strains, many researchers have actively sought alternatives or adjuvants to antimycotics.
Mojtaba Memariani, Hamed Memariani
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Human cathelicidin LL-37 rapidly disrupted colonic epithelial integrity
Biochimica et Biophysica Acta (BBA) - BiomembranesThe intestinal barrier, held together by epithelial cells and intercellular tight junction (TJ) proteins, prevents the penetration of microbial pathogens. Concurrently, intestinal epithelial cells secrete antimicrobial peptides, including cathelicidin. Cathelicidin has direct antibacterial and immunomodulatory functions, although its role in intestinal
Geeta, Kilari +3 more
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137 Expression of Cathelicidin (LL-37) in Thermal Injury
Wound Repair and Regeneration, 2008Sepsis remains a common and serious complication of major burn injury and currently accounts for over 54% of deaths in burn patients. Burns have been associated with high levels of circulating proinflammatory cytokines and immunosuppression which promotes systemic inflammatory response syndrome (SIRS) and sepsis, for which no effective treatment is ...
S. Bhat +4 more
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