Results 41 to 50 of about 191,378 (381)
Frontiers in Oncology, 2020 Our previous presurgical weight loss trial among 40 prostate cancer patients found that rapid (but not slow) weight loss resulted in increased tumor Ki67 and Cathepsin L (CTSL) gene expression.
Andrew D. Frugé +7 more
doaj +1 more source
Marine Drugs, 2022 Cathepsins are lysosomal cysteine proteases belonging to the papain family and play crucial roles in intracellular protein degradation/turnover, hormone maturation, antigen processing, and immune responses.
Yuqing Li +7 more
doaj +1 more source
Jurnal Teknologi dan Industri Pangan, 2014 Decomposition of protein by enzymatic process will lead to changes in odor, texture, and appearance of fish. The enzymes that play a role in the enzymatic process is primarily proteolytic enzymes.
Muhammad Zakiyul Fikri* +2 more
doaj +1 more source
Cathepsin K maintains the compartment of bone marrow T lymphocytes in vivo
Immunity, Inflammation and Disease, 2021 In this study, we investigated the influence of the loss of cathepsin K (Ctsk) gene on the hematopoietic system in vitro and in vivo. We found that cultures with lineage− SCA1+ KIT+ (LSK) cells on Ctsk deficient stromal cells display reduced colony ...
Renate Hausinger +11 more
doaj +1 more source
Biomedicines, 2022 Inflammation plays a vital role in regulating fibrotic processes. Beside their classical role in extracellular matrix synthesis and remodeling, fibroblasts act as immune sentinel cells participating in regulating immune responses.
Thanh-Diep Ly +8 more
doaj +1 more source
Co-Emergence of Specialized Endothelial Cells from Embryonic Stem Cells. [PDF]
, 2018 A well-formed and robust vasculature is critical to the health of most organ systems in the body. However, the endothelial cells (ECs) forming the vasculature can exhibit a number of distinct functional subphenotypes like arterial or venous ECs, as well ...
Douglas, Simone A +6 more
core +1 more source
Investigating the role of cathepsins in breast cancer progression: a Mendelian randomization study
Frontiers in OncologyBackgroundBreast cancer, a major threat to women’s health worldwide, has mechanisms of onset that remain unclear. Within the human lysosomal system, a class of enzymes known as cathepsins exhibit elevated expression levels in various malignant tumors ...
Shengyi Zhou +8 more
doaj +1 more source
Lysosomal hydrolases, from waste-bags effectors to essential multipurpose enzymes in liver fibrosis
Exploration of Digestive Diseases, 2023 Lysosomal hydrolases were once considered effectors of the waste disposal system of the cell, the endo-lysosomal system. However, they are now recognized as highly selective enzymes, which can modulate the function of several substrates, contributing to ...
Paloma Ruiz-Blázquez +2 more
doaj +1 more source
The role of proteases in pathologies of the synovial joint [PDF]
, 2008 Synovial (diarthrodial) joints are employed within the body to provide skeletal mobility and have a characteristic structure adapted to provide a smooth almost frictionless surface for articulation.
Buttle, D, Jones, GC, Riley, GP
core +1 more source
Cardiomyocyte-specific disruption of Cathepsin K protects against doxorubicin-induced cardiotoxicity
Cell Death and Disease, 2018 The lysosomal cysteine protease Cathepsin K is elevated in humans and animal models of heart failure. Our recent studies show that whole-body deletion of Cathepsin K protects mice against cardiac dysfunction.
R. Guo +4 more
semanticscholar +1 more source