Results 71 to 80 of about 191,378 (381)
Searching for novel cellular targets for MASLD and HCC within the humble lysosomal cathepsins
Exploration of Digestive DiseasesMetabolic-associated steatotic liver disease (MASLD) and its pathological version, metabolic dysfunction-associated steatohepatitis (MASH), are becoming the main leading causes of chronic liver disease almost worldwide and are the fastest growing ...
Alejandro del Castillo-Cruz +2 more
doaj +1 more source
Urinary peptidomics analysis reveals proteases involved in diabetic nephropathy [PDF]
, 2017 Mechanisms underlying the onset and progression of nephropathy in diabetic patients are not fully elucidated. Deregulation of proteolytic systems is a known path leading to disease manifestation, therefore we hypothesized that proteases aberrantly ...
Bascands, Jean-Loup +15 more
core +2 more sources
Bacteria‐Responsive Nanostructured Drug Delivery Systems for Targeted Antimicrobial Therapy
Advanced Materials, EarlyView.Bacteria‐responsive nanocarriers are designed to release antimicrobials only in the presence of infection‐specific cues. This selective activation ensures drug release precisely at the site of infection, avoiding premature or indiscriminate release, and enhancing efficacy.
Guillermo Landa +3 more
wiley +1 more source
Shipin gongye ke-jiTo clarify the mechanism of the effect of low temperature plasma sterilization on the degradation of Oncorhynchus mykiss and related cathepsin activity, Oncorhynchus mykiss fillets were treated with 70 kV dielectric barrier discharge low temperature ...
Xiejun SUN +3 more
doaj +1 more source
Ready, Set, Fuse! The Coronavirus Spike Protein and Acquisition of Fusion Competence
Viruses, 2012 Coronavirus-cell entry programs involve virus-cell membrane fusions mediated by viral spike (S) proteins. Coronavirus S proteins acquire membrane fusion competence by receptor interactions, proteolysis, and acidification in endosomes.
Tom Gallagher, Taylor Heald-Sargent
doaj +1 more source
Generic protease detection technology for monitoring periodontal disease
, 2011 Periodontal diseases are inflammatory conditions that affect the supporting tissues of teeth and can lead to destruction of the bone support and ultimately tooth loss if untreated.
Cook, Joseph P. +6 more
core +1 more source
Diminished Intracellular Invariant Chain Expression Following Vaccinia Virus Infection [PDF]
, 2009 Vaccinia virus (VV) has been used as a vaccine to eradicate smallpox and as a vaccine for HIV and tumors. However, the immunoevasive properties of VV, have raised safety concerns.
Blum, Janice S. +2 more
core +1 more source
Cathepsin B launches an apoptotic exit effort upon cell death-associated disruption of lysosomes
Cell Death Discovery, 2016 The release of cathepsin proteases from disrupted lysosomes results in lethal cellular autodigestion. Lysosomal disruption-related cell death is highly variable, showing both apoptotic and necrotic outcomes.
M. de Castro, G. Bunt, FS Wouters
semanticscholar +1 more source
Fabrication, Properties, and Applications of Scaffolds for Bone Tissue Regeneration
Advanced Materials Technologies, EarlyView.This review explores cutting‐edge biomaterials and fabrication techniques for scaffolds in bone tissue regeneration. It conducts a critical comparison of various strategies, meticulously analyzes the key contradictions in the field, and outlines an integrated development path spanning from biomaterial selection to clinical application, while ...
Shangsi Chen, Min Wang
wiley +1 more source
Chemistry Proceedings, 2021 The reaction of interaction of benzhydroxamic and 4-nitrobenzhydroxamic acids with succinyl chloride, carried out in an acetonitrile medium during boiling, was studied. It was revealed that the result of the reaction is the formation of N,N′-[succinylbis(
Yulia A. Trukhanova +2 more
doaj +1 more source