Results 91 to 100 of about 102,381 (252)
Proteolytic enzymes of pond fish: methods of isolation and properties
Известия ТИНРО, 2016 Methods of proteolytic enzymes isolation from muscle tissue and viscera of pond fish are viewed and their properties are investigated. Efficiency of enzymatic processes is determined by physical and chemical characteristics of the enzymes and, first of ...
Olga P. Dvoryaninova +2 more
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Advanced Science, EarlyView.This study identifies β‐adducin as a regulator of lysosomal integrity in ischemic neurons. Ischemia‐associated FTO loss increases m6A modification and destabilizes Add2 mRNA, reducing β‐adducin expression and promoting PLA2G4A accumulation at lysosomes.
Hui‐qin Li +9 more
wiley +1 more source
Cathepsin G cleaves and activates IL-36γ and promotes the inflammation of psoriasis
Drug Design, Development and Therapy, 2019 Jing Guo,1,* Jie Tu,1,* YingYing Hu,1,2,* GuoXin Song,3 ZhiQiang Yin1 1Department of Dermatology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China; 2Department of Medical Cosmetology, Wuqing People’s Hospital ...
Guo J, Tu J, Hu YY, Song GX, Yin ZQ
doaj
Frontiers in Neurology, 2017 BackgroundAlexander disease (AxD) is a rare disease caused by mutations in the gene encoding glial fibrillary acidic protein (GFAP). The disease is characterized by presence of GFAP aggregates in the cytoplasm of astrocytes and loss of myelin ...
Ulises Gómez-Pinedo +4 more
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Molecular cloning and characterization of cathepsin L from freshwater mussel, Cristaria plicata
, 2014 Cathepsin L is one of the crucial enzyme superfamilies and involved in the immune responses. The Cathepsin L cDNA and genome of Cristaria plicata (CpCL) was cloned from the hemocytes using degenerate primers by the rapid amplification of cDNA ends (RACE)
Hu, Xiangping +8 more
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Angewandte Chemie, EarlyView.Die Click‐Chemie hat sich von dem Aufbau kovalenter Bindungen hin zum Spalten von Bindungen weiterentwickelt. Hier wird über einen Kaskaden‐Aufbau berichtet, der diese Verfahren kombiniert, um multifunktionale biomolekulare Gerüste in einer modularen Ein‐Topf‐Reaktion aufzubauen.
Markus Staudt +9 more
wiley +1 more source
Frontiers in Aging NeuroscienceObjectiveThe observational association between cathepsin and Parkinson’s disease (PD) has been partially explored in previous research. However, the causal relationship remains unclear.
Liyu Lin +3 more
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EnABLing Cathepsin-Driven Melanoma Metastasis
Molecular & Cellular Oncology, 2018 Metastatic melanoma remains incurable for many due to its aggressive nature. Secreted cathepsins promote metastasis by cleaving matrix and activating pro-invasive proteases.
Rakshamani Tripathi, Rina Plattner
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Angewandte Chemie International Edition, EarlyView.Click chemistry has evolved from making covalent connections to also breaking bonds. Here, a cascade assembly is reported that combines these maneuvers to build multifunctional biomolecular scaffolds in a modular one‐pot reaction. The unifying azide release‐tetrazine hub clicks with a trans‐cyclooctene tag, rapidly liberates N,N‐dimethylaniline to ...
Markus Staudt +9 more
wiley +1 more source
, 2006 Chemokine processing by proteases is emerging as an important regulatory mechanism of leukocyte functions and possibly also of cancer progression. We screened a large panel of chemokines for degradation by cathepsins B and D, two proteases involved in ...
Hasan, Lara +7 more
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