Results 81 to 90 of about 94,483 (310)

Therapeutic Applications of Stimuli‐Based Release and Engineering of Extracellular Vesicles

Advanced NanoBiomed Research, EarlyView.
This review summarizes the effects of endogenous and exogenous stimuli, their effects on the natural release of extracellular vesicles, as well as their uptake and release. It also gives an overview of stimuli‐responsive EVs and their therapeutic applications. Extracellular vesicles (EVs), nano‐ to microsized lipid bilayer membrane‐bound particles, are
Gloria Kemunto, Kristen Dellinger
wiley   +1 more source

Caspase-8 is activated by cathepsin D initiating neutrophil apoptosis during the resolution of inflammation [PDF]

, 2008
In the resolution of inflammatory responses, neutrophils rapidly undergo apoptosis. We describe a new proapoptotic pathway in which cathepsin D directly activates caspase-8.
Sébastien Conus, Yousefi, Shida, Leonardo Scapozza, Remo Perozzo, Christoph Peters, Perozzo, Remo, Simon, Hans-Uwe, Hans-Uwe Simon, Reinheckel, Thomas, Conus, Sébastien, Scapozza, Leonardo, Shida Yousefi, Peters, Christoph, Thomas Reinheckel   +13 more
core   +1 more source

RETRACTION: Mechanism of p27 Upregulation Induced by Downregulation of Cathepsin B and Upar in Glioma

Molecular Oncology, EarlyView.
RETRACTION: S. Gopinath, K. Alapati, R. R. Malla, C. S. Gondi, S. Mohanam, D. H. Dinh, and J. S. Rao, “Mechanism of p27 Upregulation Induced by Downregulation of Cathepsin B and Upar in Glioma,” Molecular Oncology 5, no. 5 (2011): 426–437, https://doi.org/10.1016/j.molonc.2011.07.004.
wiley   +1 more source

Recent Advances in Virus–Host Interactions, Antiviral Bioactive Compounds, and Breeding for Disease Resistance of Porcine Epidemic Diarrhea Virus

Animal Research and One Health, EarlyView.
Basic research on the PEDV infection cycle and virus–host interactions advances the development of anti‐PEDV drugs and disease‐resistant breeding and helps strengthen disease prevention and control while reducing economic losses in the swine industry.
Heyong Wu, Aosi Qi, Shuyu Zhong, Haozhen Du, Shimeng Guo, Hongsheng Ouyang, Hongming Yuan, Daxin Pang, Zicong Xie   +8 more
wiley   +1 more source

Biomarkers Associated With Tumor Ki67 and Cathepsin L Gene Expression in Prostate Cancer Patients Participating in a Presurgical Weight Loss Trial

Frontiers in Oncology, 2020
Our previous presurgical weight loss trial among 40 prostate cancer patients found that rapid (but not slow) weight loss resulted in increased tumor Ki67 and Cathepsin L (CTSL) gene expression.
Andrew D. Frugé, Kristen S. Smith, Jennifer R. Bail, Soroush Rais-Bahrami, Soroush Rais-Bahrami, Soroush Rais-Bahrami, Wendy Demark-Wahnefried, Wendy Demark-Wahnefried   +7 more
doaj   +1 more source

The Specificity of Cathepsin D

Journal of Biological Chemistry, 1973
Abstract Bovine spleen cathepsin D has been partially purified for studies of its specificity. Isoelectric focusing of the purest preparation obtained indicated the presence of three molecular forms having approximately the same specific activity, but differing in their isoelectric points.
J B, Ferguson, J R, Andrews, I M, Voynick, J S, Fruton   +3 more
openaire   +2 more sources

Modulation of Animal Gut Health by Milk Oligosaccharide

Animal Research and One Health, EarlyView.
This review summarizes the composition and structural characteristics of MOs across different mammalian species, and elucidates their roles and mechanisms in maintaining intestinal homeostasis by regulating gut microbiome and enhancing intestinal chemical, physical and immune barriers.
Ningtao Chen, Nana Jing, Shiyu Tao, Mingyue Fei, Wentao Lv, Hua Yang, Yingping Xiao, Haiqin Wu   +7 more
wiley   +1 more source

Cathepsins and neurological diseases: a Mendelian randomization study

Frontiers in Neuroscience
BackgroundThe causal relationship between cathepsins and neurological diseases remains uncertain. To address this, we utilized a two-sample Mendelian randomization (MR) approach to assess the potential causal effect of cathepsins on the development of ...
Haitao Sun, Qingqing Tang, Xue Yan, Wanying Xie, Yueshan Xu, Weimin Zhang   +5 more
doaj   +1 more source

Anifrolumab Treatment Leads to Rapid Reduction in Urinary Biomarkers of Intrarenal Inflammation in Lupus Nephritis: Results From the Phase 2 Randomized Trial

Arthritis &Rheumatology, EarlyView.
Objective Lupus nephritis (LN) is one of the most severe manifestations of systemic lupus erythematosus (SLE) and is partially driven by type I interferon signaling. Anifrolumab, an approved treatment for patients with SLE, has been investigated in a phase 2 trial in patients with LN receiving standard therapy (TULIP‐LN, ClinicalTrials.gov identifier ...
Andrea Fava, Michelle Petri, Patrick G. Gavin, Eszter Csomor, Philip Z. Brohawn, Daniel Muthas, Adam Platt, Catharina Lindholm, Nicola Ferrari   +8 more
wiley   +1 more source

Molecular cloning and characterization of cathepsin L from freshwater mussel, Cristaria plicata

, 2014
Cathepsin L is one of the crucial enzyme superfamilies and involved in the immune responses. The Cathepsin L cDNA and genome of Cristaria plicata (CpCL) was cloned from the hemocytes using degenerate primers by the rapid amplification of cDNA ends (RACE)
Hu, Xiangping, Wen, Chungen, Gao, Qian, Xie, Yanhai, Tao, Zhiying, Li, Aihua, Hu, Xiaojuan, Hu, Baoqing, Wu, Dan   +8 more
core   +1 more source