Results 91 to 100 of about 13,268,265 (360)

Inflammatory biomarkers in sera of patients with intervertebral disc degeneration

Einstein (São Paulo)
Objective: To evaluate intervertebral disc levels of inflammatory factor (interleukin 6) and proteinase activity (cathepsin B) in patients with a degenerative disease and serum levels of interleukin 6, serum cathepsin B activity and hyaluronic acid ...
Luciano Miller Reis Rodrigues, Lilian Zerbinatti de Oliveira, Mariane de Barros Ribeiro da Silva, Camila de Melo Accardo, Adriana Braz Del Giglio, Maria Aparecida da Silva Pinhal   +5 more
doaj   +1 more source

Legionella pneumophila induces cathepsin B-dependent necrotic cell death with releasing high mobility group box1 in macrophages

Respiratory Research, 2010
Background Legionella pneumophila (LPN) can cause a lethal infectious disease with a marked inflammatory response in humans. However, the mechanism of this severe inflammation remains poorly understood.
Kakeya Hiroshi, Izumikawa Koichi, Seki Masafumi, Hasegawa Hiroo, Nakamura Shigeki, Yanagihara Katsunori, Morinaga Yoshitomo, Yamamoto Yoshihiro, Yamada Yasuaki, Kohno Shigeru, Kamihira Shimeru   +10 more
doaj   +1 more source

Parkinson disease is a TH17 dominant autoimmune disorder against accumulated alpha-synuclein [PDF]

arXiv, 2013
Parkinson disease is a very common neurodegenerative disorder. Patients usually undergo destruction of substantia nigra to develop typical symptoms such as resting tremor, hypokinesia, and rigidity. However, the exact mechanism of Parkinson disease is still unknown, so it is called idiopathic Parkinsonism.
arxiv  

Melatonin alleviates chronic stress-induced hippocampal microglia pyroptosis and subsequent depression-like behaviors by inhibiting Cathepsin B/NLRP3 signaling pathway in rats

Translational Psychiatry
Melatonin improves chronic stress-induced hippocampal damage and depression-like behaviors, but the mechanism needs further study. This study was to explore the mechanism of melatonin inhibiting microglia pyroptosis.
Zhicheng Gao, Kangxin Luo, Yulin Hu, Yunqian Niu, Xinchao Zhu, Shoujun Li, Haiyang Zhang   +6 more
doaj   +1 more source

Mathematical deep learning for pose and binding affinity prediction and ranking in D3R Grand Challenges [PDF]

arXiv, 2018
Advanced mathematics, such as multiscale weighted colored graph and element specific persistent homology, and machine learning including deep neural networks were integrated to construct mathematical deep learning models for pose and binding affinity prediction and ranking in the last two D3R grand challenges in computer-aided drug design and discovery.
arxiv  

Fluorimetric assays for cathepsin B and cathepsin H with methylcoumarylamide substrates [PDF]

Biochemical Journal, 1980
Benzyloxycarbonyl-phenylalanyl-arginine 4-methyl-7-coumarylamide was found to be an excellent substrate for the fluorimetric assay of cathepsin B, and arginine 4-methyl-7-coumarylamide for cathepsin H. Procedures were developed that are very convenient, and avoid the hazards associated with the use of naphthylamides.
openaire   +3 more sources

Safety, tolerability, pharmacokinetics and pharmacodynamics of HSK31858, a novel oral dipeptidyl peptidase‐1 inhibitor, in healthy volunteers: An integrated phase 1, randomized, double‐blind, placebo‐controlled, single‐ and multiple‐ascending dose study

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Dipeptidyl peptidase‐1 (DPP‐1) inhibitors have been studied for the treatment of neutrophil‐mediated inflammatory diseases including bronchiectasis, bronchial asthma and cystic fibrosis. This study evaluated the pharmacokinetics, pharmacodynamics, safety and tolerability of DPP‐1 inhibitor HSK31858 in healthy Chinese volunteers.
Yuhao Wang, Chao Yu, Mengyue Hu, Lu Wang, Meixia Chen, Hanmo Liu, Nan Wu, Jie Hou   +7 more
wiley   +1 more source

Salivary and plasmatic levels of tumor necrosis factor‐alpha do not correlate with the clinicopathological profile in breast cancer patients

Precision Medical Sciences, Volume 11, Issue 4, Page 155-160, December 2022., 2022
Tumor necrosis factor (TNF) levels in saliva and plasma samples from patients diagnosed with breast cancer do not correlate with clinicopathological features that are indicative of disease prognosis. Abstract Herein, we evaluated the salivary and plasmatic levels of tumor necrosis factor‐alpha (TNF‐α) in women diagnosed with breast cancer (BC; n = 20 ...
Marcelo Marcos Opolski, Vitor Teixeira Maito, Aedra Carla Bufalo Kawassaki, Janaína Carla da Silva, Rodrigo Kern, Daniel Rech, Stefania Tagliari de Oliveira, Pâmela Lonardoni Micheletti, Carolina Panis, Sabrina Grassiolli   +9 more
wiley   +1 more source

MathDL: Mathematical deep learning for D3R Grand Challenge 4 [PDF]

arXiv, 2019
We present the performances of our mathematical deep learning (MathDL) models for D3R Grand Challenge 4 (GC4). This challenge involves pose prediction, affinity ranking, and free energy estimation for beta secretase 1 (BACE) as well as affinity ranking and free energy estimation for Cathepsin S (CatS).
arxiv  

Cathepsin B Mediates the pH-Dependent Proinvasive Activity of Tumor-Shed Microvesicles

Neoplasia: An International Journal for Oncology Research, 2008
Vesicles shed by cancer cells are known to mediate several tumor-host interactions. Tumor microenvironment may, in turn, influence the release and the activity of tumor-shed microvesicles.
Ilaria Giusti, Sandra D’Ascenzo, Danilo Millimaggi, Giulia Taraboletti, Gaspare Carta, Nicola Franceschini, Antonio Pavan, Vincenza Dolo   +7 more
doaj   +1 more source