Results 221 to 230 of about 13,268,265 (360)
The role of the host—Neutrophil biology
Periodontology 2000, EarlyView., 2023 Abstract
Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira +4 morewiley +1 more sourceIn silico evaluation of missense SNPs in cancer-associated Cystatin A protein and their potential to disrupt Cathepsin B interaction. [PDF]
HeliyonHossain S, Bin Manjur OH, Shimu MSS, Sultana T, Naim MR, Siddique S, Al Mamun A, Rahman MM, Saleh MA, Hasan MR, Rahman T. +10 moreeuropepmc +1 more sourceComparative Localization of Cathepsin B Protein and Activity in Colorectal Cancer [PDF]
, 2000 Lonny G. M. Hazen, Fonnet E. Bleeker, B. Lauritzen, Sieglinde Bahns, Ji‐Ying Song, Ard Jonker, Bernard E. M. Van Driel, Hans Lyon, Ulla Hansen, Angela Köhler, Cornelis J.F. Van Noorden +10 moreopenalex +1 more sourceA Single‐Cell Transcriptome Atlas Characterizes the Immune Landscape of Human Testes During Aging
Aging Cell, EarlyView.This study utilized single‐cell RNA sequencing to analyze immune cells in 33 human testis samples (ages 21–69). We found age‐related alterations in monocytes and MRC1hi TRM, with shifts in phagocytosis, cytokine, and antigen presentation, contributing to low‐grade inflammation in aging. These findings provide insights into immune aging in human testis. Qiaoling Jiang, Lina Cui, Xichen Nie, Hui Cai, Wenxiu Zhang, Xiaojian Lu, Yifei Guo, James M. Hotaling, Bradley R. Cairns, Xiaoyan Wang, Jingtao Guo +10 morewiley +1 more sourceThe 15‐Year Survival Advantage: Immune Resilience as a Salutogenic Force in Healthy Aging
Aging Cell, EarlyView.Human aging shows puzzling diversity: similar aging rates yet vastly different health outcomes. Our study of ~17,500 people revealed a health‐promoting trait (more common in women) linked to strong immune resilience and high expression of TCF7, a key immune gene. This trait enables individuals to fight infections like COVID‐19 more effectively, respond Muthu Saravanan Manoharan, Grace C. Lee, Nathan Harper, Justin A. Meunier, Marcos I. Restrepo, Fabio Jimenez, Sreenath Karekatt, Anne P. Branum, Alvaro A. Gaitan, Kian Andampour, Alisha M. Smith, Michael Mader, Michelle Noronha, Devjit Tripathy, Nu Zhang, Alvaro G. Moreira, Lavanya Pandranki, South Texas Veterans Health Care System (STVHCS) COVID‐19 Clinical team, STVHCS COVID‐19 Vaccine team, STVHCS COVID‐19 Convalescent care team, STVHCS Center for Personalized Medicine, Sandra Sanchez‐Reilly, Hanh D. Trinh, Clea Barnett, Luis Angel, Leopoldo N. Segal, Susannah Nicholson, Robert A. Clark, Weijing He, Jason F. Okulicz, Sunil K. Ahuja, Andrew Carrillo, Chanda Dhami, Gaeun Jo, Krupa Jiva, Ernesto Robinson, Caitlyn A. Winter, Lauryn A. Winter, Erin Stewart, Joseph M. Yabes, Peter Melby, Cody R. Butler, Mohamed I. Abdalla, Sandra G. Adams, Yemi Adebayo, Joseph Agnew, Saleem Ali, Gregory Anstead, Antonio Anzueto, Marichu Balmes, Jennifer Barker, Raymond Benavides, Velma Bible, Angela Birdwell, Stacy Braddy, Stephen Bradford, Heather Briggs, Jose A. Cadena Zuluaga, Judith Marin‐Corral, Jennifer J. Dacus, Patrick J. Danaher, Scott A. DePaul, Jill Dickerson, Jollynn Doanne, Samantha Elbel, Miguel Escalante, Corina Escamilla, Valerie Escamilla, Robert Farrar, David Feldman, Debra Flores, Julianne Flynn, Delvina Ford, Joanna D. Foy, Megan Freeman, Samantha Galley, Jessica Garcia, Maritza Garza, Sherraine Gilman, Melanie Goel, Jennifer Gomez, Varun K. Goyal, Sally Grassmuck, Susan Grigsby, Joshua Hanson, Brande Harris, Audrey Haywood, Joan M. Hecht, Cecilia Hinojosa, Tony T. Ho, Teri Hopkins, Aneela N. Hussain, Ali Jabur, Pamela Jewell, Thomas B. Johnson, Austin C. Lawler, Monica Lee, Chadwick S. Lester, Stephanie M. Levine, Haidee V. Lewis, Angel Louder, Charmaine Mainor, Rachel Maldonado, Celida Martinez, Yvette Martinez, Chloe Mata, Neil McElligott, Laura Medlin, Myra Mireles, Joanna Moreno, Kathleen Morneau, Julie Muetz, Samuel B. Munro, Charlotte Murray, Anoop Nambiar, Daniel Nassery, Robert Nathanson, Kimberly Oakman, Jane O’Rorke, Cheryl Padgett, Sergi Pascual‐Guardia, Marisa Patterson, Graciela L. Perez, Rogelio Perez, Jay I. Peters, Rogelio Perez III, Robert E. Phillips, Patrick B. Polk, Michael A. Pomager, Kristy J. Preston, Kevin C. Proud, Jacqueline A. Pugh, Michelle Rangel, Temple A. Ratcliffe, Renee L. Reichelderfer, Evan M. Renz, Jeanette Ross, Teresa Rudd, Maria E. Sanchez, Tammy Sanders, Kevin C. Schindler, David Schmit, Raj T. Sehgal, Claudio Solorzano, Nilam Soni, Win S. Tam, Edward J. Tovar, Sadie A. Trammell Velasquez, Anna R. Tyler, Anjuli Vasquez, Maria C. Veloso, Steven G. Venticinque, Jorge A. Villalpando, Melissa Villanueva, Lauren Villegas, Megan Walker, Andrew Wallace, Maria Wallace, Emily Wang, Stephanie Wickizer, Andreia Williamson, Andrea Yunes, Katharine H. Zentner, Azaneth Arellanes, Ashley B. Banfield, Stephanie N. Bolan‐Reding, Roxanne Colazo, Katherine S. DeLeon, Norma G. Diaz, Mario A. Garza, Raed Kadhume, Hue Mang, Erwin Paleracio, Robert F. Quitta, Laura J. Ramirez, Marzieh Salehi, Cynthia J. Varela +176 morewiley +1 more sourceIdentifying PDAP1 as a Biological Target on Human Longevity: Integration of Mendelian Randomization, Cohort, and Cell Experiments Validation Study
Aging Cell, EarlyView.Integration of multi‐omics analyses reveals PDAP1 as one of the key regulators of longevity and aging. Mendelian randomization, colocalization, prospective studies, and in vitro experiments highlight PDAP1's effects on mortality, lifespan, and cellular senescence.Tianzhichao Hou, Zimo Sha, Qi Wang, Yuanyue Zhu, Zheng Zhu, Huajie Dai, Yijie Zhu, Tiange Wang, Mian Li, Zhiyun Zhao, Yu Xu, Jieli Lu, Jie Zheng, Jing Ye, Weiqing Wang, Guang Ning, Yufang Bi, Weiguo Hu, Min Xu +18 morewiley +1 more source
