Results 51 to 60 of about 13,268,265 (360)

Cathepsin B Activity Initiates Apoptosis via Digestive Protease Activation in Pancreatic Acinar Cells and Experimental Pancreatitis*

Journal of Biological Chemistry, 2016
Pancreatitis is associated with premature activation of digestive proteases in the pancreas. The lysosomal hydrolase cathepsin B (CTSB) is a known activator of trypsinogen, and its deletion reduces disease severity in experimental pancreatitis.
M. Sendler, Sandrina Maertin, Daniel S. John, Maria Persike, F. Weiss, B. Krüger, T. Wartmann, Preshit R Wagh, W. Halangk, N. Schaschke, J. Mayerle, M. Lerch   +11 more
semanticscholar   +1 more source

Expression of Cathepsins B, D, and G in Isocitrate Dehydrogenase-Wildtype Glioblastoma

Frontiers in Surgery, 2017
AimTo investigate the expression of cathepsins B, D, and G, in relation to the cancer stem cell (CSC) subpopulations, we have previously characterized within isocitrate dehydogenase (IDH)-wildtype glioblastoma (IDHWGB).Methods3,3-Diaminobezidine (DAB ...
Sabrina P. Koh, Agadha C. Wickremesekera, Agadha C. Wickremesekera, Helen D. Brasch, Reginald Marsh, Swee T. Tan, Swee T. Tan, Tinte Itinteang   +7 more
doaj   +1 more source

Cathepsin B modulates lysosomal biogenesis and host defense against Francisella novicida infection

Journal of Experimental Medicine, 2016
Kanneganti and collaborators propose that the lysosomal protease cathepsin B provides a checkpoint for activation of the transcription factor TFEB and lysosomal biogenesis and explore the impact of this pathway on host defense against bacterial infection.
Xiaopeng Qi, Si Ming Man, R. Malireddi, Rajendra Karki, Christopher R. Lupfer, Prajwal Gurung, G. Neale, C. Guy, M. Lamkanfi, T. Kanneganti   +9 more
semanticscholar   +1 more source

Juvenile mucopolysaccharidosis plus disease caused by a missense mutation in VPS33A

Human Mutation, Volume 43, Issue 12, Page 2265-2278, December 2022., 2022
Abstract A rare and fatal disease resembling mucopolysaccharidosis in infants, is caused by impaired intracellular endocytic trafficking due to deficiency of core components of the intracellular membrane‐tethering protein complexes, HOPS, and CORVET. Whole exome sequencing identified a novel VPS33A mutation in a patient suffering from a variant form of
Elena V. Pavlova, Dorit Lev, Marina Michelson, Keren Yosovich, Hila Gur Michaeli, Nicholas A. Bright, Paul T. Manna, Veronica Kane Dickson, Karen L. Tylee, Heather J. Church, J. Paul Luzio, Timothy M. Cox   +11 more
wiley   +1 more source

Purification and Characterization of Cathepsin B from the Muscle of Horse Mackerel Trachurus japonicus

Marine Drugs, 2015
An endogenous protease in fish muscle, cathepsin B, was partially purified and characterized from horse mackerel meat. On SDS-PAGE of the purified enzyme under reducing conditions, main protein bands were detected at 28 and 6 kDa and their respective N ...
Asami Yoshida, Megumi Ohta, Koichi Kuwahara, Min-Jie Cao, Kenji Hara, Kiyoshi Osatomi   +5 more
doaj   +1 more source

Two proteases with caspase‐3‐like activity, cathepsin B and proteasome, antagonistically control ER‐stress‐induced programmed cell death in Arabidopsis

New Phytologist, 2017
Summary Programmed cell death (PCD) induced by endoplasmic reticulum (ER) stress is implicated in various plant physiological processes, yet its mechanism is still elusive.
Yaomin Cai, Jia Yu, Yuan Ge, Aleksandr Mironov, P. Gallois   +4 more
semanticscholar   +1 more source

Cathepsin B trafficking in thyroid carcinoma cells

Thyroid Research, 2011
Background The cysteine peptidase cathepsin B is important in thyroid physiology by being involved in prohormone processing initiated in the follicle lumen and completed in endo-lysosomal compartments.
Tedelind Sofia, Jordans Silvia, Resemann Henrike, Blum Galia, Bogyo Matthew, Führer Dagmar, Brix Klaudia   +6 more
doaj   +1 more source

Eimeripain, a cathepsin B-like cysteine protease, expressed throughout sporulation of the apicomplexan parasite Eimeria tenella. [PDF]

PLoS ONE, 2012
The invasion and replication of Eimeria tenella in the chicken intestine is responsible for avian coccidiosis, a disease that has major economic impacts on poultry industries worldwide. E.
Anaïs Rieux, Simon Gras, Fabien Lecaille, Alisson Niepceron, Marilyn Katrib, Nicholas C Smith, Gilles Lalmanach, Fabien Brossier   +7 more
doaj   +1 more source

Non-invasive in vivo imaging of tumour-associated cathepsin B by a highly selective inhibitory DARPin

Theranostics, 2017
Cysteine cathepsins often contribute to cancer progression due to their overexpression in the tumour microenvironment and therefore present attractive targets for non-invasive diagnostic imaging. However, the development of highly selective and versatile
Lovro Kramer, M. Renko, J. Završnik, D. Turk, M. Seeger, O. Vasiljeva, M. Grütter, V. Turk, B. Turk   +8 more
semanticscholar   +1 more source

Cystatin A promotes the antitumor activity of T helper type 1 cells and dendritic cells in murine models of pancreatic cancer

Molecular Oncology, EarlyView.
Pancreatic ductal adenocarcinoma (PDAC) is a disease with very poor prognosis due to therapeutic limitations. We investigated the antitumor effects of cystatin A (CSTA) in PDAC murine models. We are first to confirm that CSTA enhances T helper type 1‐mediated antitumor effects through promotion of dendritic cells and M1 macrophage activity. CSTA can be
Alessandro Nasti, Shingo Inagaki, Tuyen Thuy Bich Ho, Akihiro Seki, Keiko Yoshida, Kosuke Satomura, Yoshio Sakai, Shuichi Kaneko, Taro Yamashita   +8 more
wiley   +1 more source