Results 71 to 80 of about 13,268,265 (360)

Reduced Bone Mass and Increased Osteocyte Tartrate‐Resistant Acid Phosphatase (TRAP) Activity, But Not Low Mineralized Matrix Around Osteocyte Lacunae, Are Restored After Recovery From Exogenous Hyperthyroidism in Male Mice

Journal of Bone and Mineral Research, Volume 38, Issue 1, Page 131-143, January 2023., 2023
ABSTRACT Hyperthyroidism causes secondary osteoporosis through favoring bone resorption over bone formation, leading to bone loss with elevated bone fragility. Osteocytes that reside within lacunae inside the mineralized bone matrix orchestrate the process of bone remodeling and can themselves actively resorb bone upon certain stimuli.
Eva Maria Wölfel, Franziska Lademann, Haniyeh Hemmatian, Stéphane Blouin, Phaedra Messmer, Lorenz C. Hofbauer, Björn Busse, Martina Rauner, Katharina Jähn‐Rickert, Elena Tsourdi   +9 more
wiley   +1 more source

Cathepsin B promotes colorectal tumorigenesis, cell invasion, and metastasis

Molecular Carcinogenesis, 2015
Cathepsin B is a cysteine proteinase that primarily functions as an endopeptidase within endolysosomal compartments in normal cells. However, during tumoral expansion, the regulation of cathepsin B can be altered at multiple levels, thereby resulting in ...
Benjamin Bian, S. Mongrain, S. Cagnol, M. Langlois, J. Boulanger, G. Bernatchez, J. Carrier, F. Boudreau, N. Rivard   +8 more
semanticscholar   +1 more source

Tumoroid Model Reveals Synergistic Impairment of Metabolism by Iron Chelators and Temozolomide in Chemo‐Resistant Patient‐derived Glioblastoma Cells

Advanced Science, EarlyView.
This study investigates the metabolic vulnerabilities of glioblastoma (GBM), an aggressive brain tumor. Research demonstrates that iron chelation therapy, in combination with standard chemotherapy, significantly enhances the efficacy of treatment against resistant GBM cells in a 3D tumoroid model.
Meitham Amereh, Amir Seyfoori, Shahla Shojaei, Sarah Lane, Tian Zhao, Mahdieh Shokrollahi Barough, Julian J. Lum, Patrick Walter, Mohsen Akbari   +8 more
wiley   +1 more source

HU308 Mitigates Osteoarthritis by Stimulating Sox9‐Related Networks of Carbohydrate Metabolism

Journal of Bone and Mineral Research, Volume 38, Issue 1, Page 154-170, January 2023., 2023
ABSTRACT Osteoarthritis (OA) is characterized by progressive, irreversible erosion of articular cartilage accompanied by severe pain and immobility. This study aimed to assess the effect and mechanism of action of HU308, a selective cannabinoid receptor type 2 (CB2) agonist, in preventing OA‐related joint damage. To test the assumption that HU308 could
Idan Carmon, Lital Zecharyahu, Jinan. Elayyan, Sai R. K. Meka, Eli Reich, Leonid Kandel, Andras Bilkei‐Gorzo, Andreas Zimmer, Raphael Mechoulam, Nataly Kravchenko‐Balasha, Mona Dvir‐Ginzberg   +10 more
wiley   +1 more source

Downregulation of uPAR and cathepsin B induces apoptosis via regulation of Bcl-2 and Bax and inhibition of the PI3K/Akt pathway in gliomas.

PLoS ONE, 2010
BackgroundGlioma is the most commonly diagnosed primary brain tumor and is characterized by invasive and infiltrative behavior. uPAR and cathepsin B are known to be overexpressed in high-grade gliomas and are strongly correlated with invasive cancer ...
Ramarao Malla, Sreelatha Gopinath, Kiranmai Alapati, Christopher S Gondi, Meena Gujrati, Dzung H Dinh, Sanjeeva Mohanam, Jasti S Rao   +7 more
doaj   +1 more source

Ceramide activates lysosomal cathepsin B and cathepsin D to attenuate autophagy and induces ER stress to suppress myeloid-derived suppressor cells

OncoTarget, 2016
Myeloid-derived suppressor cells (MDSCs) are immune suppressive cells that are hallmarks of human cancer. MDSCs inhibit cytotoxic T lymphocytes (CTLs) and NK cell functions to promote tumor immune escape and progression, and therefore are considered key ...
Feiyan Liu, Xia Li, Chunwan Lu, A. Bai, J. Bielawski, A. Bielawska, B. Marshall, P. Schoenlein, Iryna Lebedyeva, Kebin Liu   +9 more
semanticscholar   +1 more source

Icaritin Represses Autophagy to Promote Colorectal Cancer Cell Apoptosis and Sensitized Low‐Temperature Photothermal Therapy via Targeting HSP90‐TXNDC9 Interactions

Advanced Science, EarlyView.
Icaritin demonstrates broad antitumor effects by inhibiting colorectal cancer (CRC) cell proliferation, migration, invasion, and causing cell cycle arrest. It induces apoptosis by repressing autophagic flux through disrupting HSP90‐TXNDC9 interactions.
Dan He, Siliang Chen, Xiaoyun Wang, Xiang Wen, Changyang Gong, Lei Liu, Gu He   +6 more
wiley   +1 more source

Molecular mechanisms, physiological roles, and therapeutic implications of ion fluxes in bone cells: Emphasis on the cation‐Cl− cotransporters

Journal of Cellular Physiology, Volume 237, Issue 12, Page 4356-4368, December 2022., 2022
Ion transport systems in the membranes of osteoblasts and osteoclasts play a key role in bone remodeling by coordinating the movement of Ca2+, PO42−, and H+ ions in and out of the osseous matrix. Based on the evidence available, the cation‐Cl− cotransporters could act as unexpectedly important players in this regard.
Alexandre P. Garneau, Samira Slimani, Ludwig Haydock, Thy‐René Nsimba‐Batomene, Florence C.M. Préfontaine, Mathilde M. Lavoie, Laurence E. Tremblay, Marie‐Jeanne Fiola, Fabrice Mac‐Way, Paul Isenring   +9 more
wiley   +1 more source

Cathepsin B is a New Drug Target for Traumatic Brain Injury Therapeutics: Evidence for E64d as a Promising Lead Drug Candidate

Frontiers in Neurology, 2015
There is currently no therapeutic drug treatment for traumatic brain injury (TBI) despite decades of experimental clinical trials. This may be because the mechanistic pathways for improving TBI outcomes have yet to be identified and exploited.
Gregory R Hook, J. Jacobsen, K. Grabstein, Mark Kindy, Mark Kindy, V. Hook, V. Hook   +6 more
semanticscholar   +1 more source

An Insect Salivary Sheath Protein Triggers Plant Resistance to Insects and Pathogens as a Conserved HAMP

Advanced Science, EarlyView.
The salivary sheath protein myosin from SBPH is critical for the formation of the salivary sheath and feeding. However, myosin functions as a HAMP and triggered plant BAK1‐mediated PTI responses, which include the activation of calcium signaling pathways, MAPK phosphorylation, ROS bursts, and cell death, thereby triggering JA pathway.
Liangxuan Qi, Jing Li, Shuai Li, Jing Li, Han Wang, Lei Yang, Xinyang Tan, Zhichang Zhao, Guanghua Luo, Maofeng Jing, Ary A. Hoffmann, Jichao Fang, Rui Ji   +12 more
wiley   +1 more source