Expression and significance of cathepsin C and cathepsin D during pregnancy and Preeclampsia [PDF]
Reproductive Biology and Endocrinology, 2023 Background Cathepsin C (Cat C) is involved in the inflammatory-immune system and can be degraded by cathepsin D (Cat D). Preeclampsia (PE) and the inflammation-immunity relationship is currently a hot research topic, but there are still few studies.
Jingzhe Song +4 more
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Targeting Cathepsin C in PR3-ANCA Vasculitis. [PDF]
J Am Soc Nephrol, 2022 Background The ANCA autoantigens proteinase 3 (PR3) and myeloperoxidase (MPO) are exclusively expressed by neutrophils and monocytes. ANCA-mediated activation of these cells is the key driver of the vascular injury process in ANCA-associated vasculitis (AAV), and neutrophil serine proteases (NSPs) are disease mediators ...
Jerke U +10 more
europepmc +4 more sources
Dipeptide analogues of fluorinated aminophosphonic acid sodium salts as moderate competitive inhibitors of cathepsin C [PDF]
Beilstein Journal of Organic Chemistry, 2023 In this paper, we present the solvolysis reaction of dipeptide analogues of fluorinated aminophosphonates with simultaneous quantitative deprotection of the amino group.
Karolina Wątroba +2 more
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Cathepsin L increases invasion and migration of B16 melanoma [PDF]
Cancer Cell International, 2007 Background Most cancers express elevated protease levels which contribute to certain aspects of tumor behavior such as growth, metastatic spread, and angiogenesis.
Cox James L, Yang Zhen
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Unraveling the gut microbiota–SCFAs–cathepsin C pathway in preeclampsia: a novel therapeutic target [PDF]
Frontiers in ImmunologyIntroductionPreeclampsia (PE) is a severe obstetric syndrome linked to impaired maternal-fetal immune tolerance, placental insufficiency, and systemic inflammatory activation.
Fan Lu +3 more
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Role of cathepsin A and cathepsin C in the regulation of glycosidase activity
Folia Histochemica et Cytobiologica, 2012 Increased tissue activity of cathepsin A and cathepsin C can be observed in many pathological conditions. It is associated with an enhanced degradation of glycosaminoglycans, proteoglycans, and glycoproteins, and results in their decreased tissue content.
Anna Justyna Milewska +4 more
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N-Acetyldopamine dimers from Oxya chinensis sinuosa attenuates lipopolysaccharides induced inflammation and inhibits cathepsin C activity [PDF]
Computational and Structural Biotechnology Journal, 2022 Oxya chinensis sinuosa (rice field grasshopper) is an edible insect with numerous health beneficial properties, traditionally being used to treat many ailments in Korea and other countries. O.
Ashutosh Bahuguna +9 more
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The International Journal of Biological Markers, 2008 Numerous studies have linked cathepsins and their inhibitor cystatin C to tumor invasion and metastasis. We examined whether cathepsin B, cathepsin H, cathepsin X and cystatin C could be detected in sera from women with early-stage or inflammatory breast
J. Decock +5 more
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Targeting cathepsin C ameliorates murine acetaminophen-induced liver injury. [PDF]
TheranosticsAcetaminophen (APAP) overdosing is a major cause of acute liver failure worldwide and an established model for drug-induced acute liver injury (ALI). While studying gene expression during murine APAP-induced ALI by 3'mRNA sequencing (massive analysis of cDNA ends, MACE), we observed splenic mRNA accumulation encoding for the neutrophil serine proteases
Raith J +6 more
europepmc +4 more sources
Papillon-Lefèvre Syndrome: 17-Year Dental Follow-Up. Case Report.
Journal of Oral Research, 2023 Introduction: The present report describes the case of a 12-year-old patient with 17-year follow-up who was previously diagnosed with Papillon-Lefèvre Syndrome (PLS), which is a rare autosomal recessive irregularity in the cathepsin C gene (CTSC ...
Miguel Melchor-Soto +6 more
doaj +1 more source