Results 11 to 20 of about 118,840 (299)

The Homology Modeling and Docking Investigation of Human Cathepsin B [PDF]

International Journal of Medical Toxicology and Forensic Medicine, 2020
Background: Cathepsin B comprises a group of lysosomal cysteine proteases belonging to the Papain family; it has an intracellular function in the process of protein catabolism, antigen processing in the immune response, and Alzheimer’s disease.
Afshin Khara, Ehsan Jahangirian, Hossein Tarrahimofrad   +2 more
doaj   +1 more source

Research progress in Haim-Munk syndrome

Pifu-xingbing zhenliaoxue zazhi, 2023
Haim-Munk syndrome is an extremely rare autosomal recessive genetic disease, characterized by palmoplantar hyperkeratosis, severe early-onset periodontitis, arachnodactyly, acro-osteolysis, pes planus foot and nail atrophic deformation.
Dandan DONG, Yonghui XU, Yufeng LIN, Jialing CHEN, Qian WANG, Liangmei HUANG, Jianqiang SHI   +6 more
doaj   +1 more source

Lysosomal dysfunction promotes cleavage and neurotoxicity of tau in vivo. [PDF]

PLoS Genetics, 2010
Expansion of the lysosomal system, including cathepsin D upregulation, is an early and prominent finding in Alzheimer's disease brain. Cell culture studies, however, have provided differing perspectives on the lysosomal connection to Alzheimer's disease,
Vikram Khurana, Ilan Elson-Schwab, Tudor A Fulga, Katherine A Sharp, Carin A Loewen, Erin Mulkearns, Jaana Tyynelä, Clemens R Scherzer, Mel B Feany   +8 more
doaj   +1 more source

The behavior of cathepsin D during milk processing and its contribution to bitterness in a model fresh cheese

Journal of Dairy Science, 2023
: The bovine endopeptidase cathepsin D was investigated regarding its temperature-dependent inactivation and ability to form bitter peptides within a spiked model fresh cheese.
Gudrun Horstmann, Johannes Schäfer, Melanie Rosenberger, Ines Seitl, Jörg Hinrichs, Lutz Fischer   +5 more
doaj   +1 more source

Oral management of poorly understood Papillon–Lefèvre syndrome – A case report

SRM Journal of Research in Dental Sciences, 2022
Rationale: Papillon-Lefèvre syndrome (PLS) is a rare genodermatosis with autosomal-recessive genetic inheritanceand has features mainly palmoplantar hyperkeratosis and rapidly progressing severe periodontitis leading to early loss of deciduous and ...
Deepak Sharma, Nancy Changra, Priyanka Kharbanda, Shanta Negi, Ankit Mahajan, Suresh Kumar Sachdeva   +5 more
doaj   +1 more source

Status and future directions of anti-metastatic cancer nanomedicines for the inhibition of cathepsin L [PDF]

, 2020
Angiogenesis, tissue invasion and metastasis in the tumour microenvironment are all critical hallmarks of cancer. Upregulation of cathepsin L plays an important role in angiogenesis and metastasis through its ability to degrade the extracellular matrix ...
Pranjol, Md Zahidul I, Tabish, Tanveer A, Whatmore, Jacqueline L, Zhang, Shaowei   +3 more
core   +2 more sources

Characterization of Cysteine Cathepsin Expression in the Central Nervous System of Aged Wild-Type and Cathepsin-Deficient Mice

Applied Sciences, 2022
The association of cathepsin proteases in neurobiology is increasingly recognized. Our previous studies indicated that cathepsin-K-deficient (Ctsk−/−) mice have learning and memory impairments.
Denise M. T. Yu, Stephanie Dauth, Michael B. Margineanu, Valentina Snetkova, Maren Rehders, Silvia Jordans, Klaudia Brix   +6 more
doaj   +1 more source

Epoxysuccinyl peptide-derived cathepsin B inhibitors: Modulating membrane permeability by conjugation with the C-terminal heptapeptide segment of penetratin [PDF]

, 2002
Besides its physiological role in lysosomal protein breakdown, extralysosomal cathepsin B has recently been implicated in apoptotic cell death. Highly specific irreversible cathepsin B inhibitors that are readily cellpermeant should be useful tools to ...
Assfalg-Machleidt, Irmgard, Deluca, Dominga, Höhneke, Clara, Machleidt, Werner, Schaschke, Norbert, Sommerhoff, Christian P.   +5 more
core   +1 more source

Discordance in cathepsin B and cystatin C expressions in bronchoalveolar fluids between murine bleomycin-induced fibrosis and human idiopathic fibrosis [PDF]

, 2015
International audienceAbstractThe activity of cysteine cathepsin B increased markedly in lung homogenates and in bronchoalveolar lavage fluids (BALF) of the mouse model of bleomycin-induced lung fibrosis after 14 days of challenge.
Couillin, Isabelle, Gombault, Aurélie, Kasabova, Mariana, Lalmanach, Gilles, Lecaille, Fabien, Marchand-Adam, Sylvain, Reinheckel, Thomas, Villeret, Bérengère   +7 more
core   +3 more sources

Association Between Cathepsin S, Cystatin C and High Sensitivity C-Reactive Protein (hsCRP) with Oxidized LDL (Ox-LDL) in Men with Central Obesity

Indonesian Biomedical Journal, 2012
BACKGROUND: Inflammation is a central feature of the atherosclerotic process particularly in obesity. hsCRP, a marker of inflammation, may be directly involved in all phases of atheroslerosis by complement activation, apoptosis, vascular cell activation,
Emmy F Harefa, Ilhamjaya Patellongi, Marita Kaniawati   +2 more
doaj   +1 more source