Results 101 to 110 of about 113,729 (277)
Pathophysiology of acute experimental pancreatitis: Lessons from genetically engineered animal models and new molecular approaches [PDF]
, 2005 The incidence of acute pancreatitis is growing and worldwide population-based studies report a doubling or tripling since the 1970s. 25% of acute pancreatitis are severe and associated with histological changes of necrotizing pancreatitis. There is still
Anne Barbara Tietz +38 more
core +1 more source
Advanced Science, EarlyView.Fibronectin regulates the extracellular matrix (ECM)–myofibroblast cycle through three key steps: (1) its secretion and assembly by myofibroblasts (inhibited by pUR4); (2) collagen deposition along its scaffold (inhibited by R1R2); and (3) integrin α5β1‐mediated mechanotransduction (inhibited by ATN161).
Wenlong Ma +10 more
wiley +1 more source
The International Journal of Biological Markers, 1996 The aim of this study was the survey of cathepsin D determination in a large group of patients enrolled at several centers, under the coordination of the Italian Committee for Quality Control in the Oncological Laboratory.
D. Pelizzola +20 more
doaj +1 more source
Cancer Biology & Therapy, 2010 Proteases are a large and important group of enzymes, with essential roles in a great diversity of biological processes in all living organisms.1 Proteases are classified according the mechanisms by which they catalyze hydrolysis of peptide bonds within their protein substrates: serine, cysteine, threonine, metallo- and aspartic protease classes are ...
openaire +2 more sources
Advanced Science, EarlyView.This study delineates macrophage heterogeneity along the acute kidney injury to chronic kidney disease transition. Single‐cell RNA sequencing reveals a TRAP5+ scar‐associated macrophage subset driven by Spp1–Cd44 signaling and mitochondrial metabolic reprogramming.
Chenxi Wang +13 more
wiley +1 more source
Clinical Significance of Cathepsin D Concentration in Tumor Cytosol of Primary Breast Cancer
The International Journal of Biological Markers, 2005 Background Cathepsin D is the proteolytic enzyme most frequently implicated as a prognostic factor in primary breast cancer. In the present study we evaluated by means of an immunoradiometric assay the tumor content of this protease in primary breast ...
J. Rodríguez +12 more
doaj +1 more source
Macrophage Extracellular Traps in Immunity and Cancer
Advanced Science, EarlyView.As a macrophage‐mediated innate defense mechanism, the dysregulated release of METs drives chronic inflammation and influences tumor progression. Furthermore, METs exhibit a functional duality within the tumor microenvironment, capable of both promoting and suppressing tumor development.
Junyao Li +5 more
wiley +1 more source
Advanced Science, EarlyView.A cascade recognition of activatable probe ANG‐hCy‐MC is used for high‐precision depiction of glioblastoma (GBM) margin. This probe crosses the blood‐brain barrier (BBB) through LRP1 receptor‐mediated transport and provides excellent fluorescence signal contrast between the tumor and normal tissues, thereby enabling ultra‐selective imaging and precise ...
Xinru An +8 more
wiley +1 more source
Clinical Medicine Insights: Cardiology, 2008 We have performed a proteomic analysis of peripheral blood monocytes from ACS patients in comparison with healthy subjects and stable coronary patients in order to search novel biomarkers of ACS in circulating monocytes.
Maria G. Barderas +10 more
doaj +1 more source
Generic protease detection technology for monitoring periodontal disease
, 2011 Periodontal diseases are inflammatory conditions that affect the supporting tissues of teeth and can lead to destruction of the bone support and ultimately tooth loss if untreated.
Cook, Joseph P. +6 more
core +1 more source