Results 181 to 190 of about 114,831 (298)

Sustained release of cathepsin D/cathepsin K from injectable hydrogel microspheres in anti-photoaging. [PDF]

Mater Today Bio
Hou W, Lin Z, Chen X, Sun Y, Lin Y, Peng M, Zhou F, Jiang H, Li Y, Zheng Y.   +9 more
europepmc   +1 more source

Extracellular matrix and proteolysis: mechanisms driving irreversible changes and shaping cell behavior

The FEBS Journal, EarlyView.
Irreversible ECM proteolysis by remodeling enzymes shapes development, homeostasis, and disease. ECM‐degrading proteases display cell specificity and are governed by shared mechanisms, exhibiting functional redundancy in generating matrikines, growth factors, and cytokines.
Inna Solomonov, Orit Kollet, Irit Sagi
wiley   +1 more source

Cathepsin D promotes acute myeloid leukemia progression through stabilization of the anti-apoptotic proteins. [PDF]

Cell Death Dis
Jiang H, Wang Y, Wang C, Yang L, Wang S, Wang F, Xue S, Zhang Z, Fu H, Dong T, Yuan J, Li Z, Li K.   +12 more
europepmc   +1 more source

Lysosomal cathepsin D mediates endogenous mucin glycodomain catabolism in mammals. [PDF]

Proc Natl Acad Sci U S A, 2022
Pedram K, Laqtom NN, Shon DJ, Di Spiezio A, Riley NM, Saftig P, Abu-Remaileh M, Bertozzi CR.   +7 more
europepmc   +1 more source

Proteolysis-induced pathomechanisms in acute inflammation and related therapeutic approaches [PDF]

, 1991
A Billing, A Billing, B Blauhut, C Gippner-Steppert, D Inthorn, D Nast-Kolb, H Hoffmann, H Vinazzer, I Assfalg-Machleidt, I Schraufstatter, JI Weitz, K-H Duswald, M Jochum, M Jochum, M Jochum, M Jochum, M Jochum, M Jochum, M Jochum, M Jochum, M Siebeck, M Siebeck, M Spannagl, MD Wewers, RE Jordan, S Idell, S Neumann, TE Emerson, U Obertacke, YT Wachtfogel, YT Wachtfogel   +30 more
core   +1 more source

A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer

The FEBS Journal, EarlyView.
Matrix metalloproteinases (MMPs) orchestrate cancer progression and metastasis through proteolytic and non‐proteolytic actions. By remodeling the tumor microenvironment, enhancing growth factor availability, and modulating cell behavior, MMPs promote proliferation, migration or invasion, and epithelial‐to‐mesenchymal transition. Alongside extracellular
Zoi Piperigkou, Sylvia Mangani, Spyros Kremmydas, Nikolaos E. Koletsis, Nikos K. Karamanos   +4 more
wiley   +1 more source

A Dual-Function "TRE-Lox" System for Genetic Deletion or Reversible, Titratable, and Near-Complete Downregulation of Cathepsin D. [PDF]

Int J Mol Sci, 2023
Terron HM, Maranan DS, Burgard LA, LaFerla FM, Lane S, Leissring MA.   +5 more
europepmc   +1 more source

Interactions between small leucine‐rich proteoglycans and proteases: implications for tissue homeostasis and pathology

The FEBS Journal, EarlyView.
Small leucine‐rich proteoglycans (SLRPs) are key modulators of extracellular matrix structure and signaling. Their proteolytic processing by MMPs (Matrix Metalloproteinases), ADAMTS (disintegrin and metalloprotease with thrombospondin motifs), and serine proteases generates bioactive fragments that regulate collagen remodeling, inflammation, and ...
Maria Konstantaraki, Lydia‐Nefeli Thrapsanioti, Aikaterini Berdiaki, Ioanna Spyridaki, Dragana Nikitovic   +4 more
wiley   +1 more source

Cathepsin-D and outcomes in peripartum cardiomyopathy: Results from IPAC. [PDF]

Am Heart J Plus
Polsinelli VB, Hanley-Yanez K, McTiernan CF, Modi K, Haythe J, Skopicki H, Elkayam U, Cooper LT, Fett JD, McNamara DM, IPAC investigators.   +10 more
europepmc   +1 more source

Specific proteins of inflammatory cells and alpha1-proteinase inhibitor in alveolar epithelial lining fluid of polytraumatized patients [PDF]

, 1991
Jochum, Marianne, Sturm, J. A.
core   +1 more source