Results 231 to 240 of about 66,677 (282)

Unraveling Lysosomal Exocytosis: From Molecular Mechanisms to Physiological Functions

Traffic, Volume 27, Issue 1, March 2026.
Lysosomal exocytosis is propelled by specific molecular mechanisms that direct its microtubule‐dependent transport and subsequent fusion with the plasma membrane. This process fulfills essential physiological functions such as plasma membrane repair, maintenance of cellular homeostasis, and participation in signal transduction.
Shanshan Jiang, Jingyi Fu, Shan Li, Zehui Li, Qirui Zhao, Yuqi Yin, Mei Yang, Yonghua Wang   +7 more
wiley   +1 more source

Enhancement of Acetate-Induced Apoptosis of Colorectal Cancer Cells by Cathepsin D Inhibition Depends on Oligomycin A-Sensitive Respiration. [PDF]

Biomolecules
Alves S, Santos-Pereira C, Oliveira CSF, Preto A, Chaves SR, Côrte-Real M.   +5 more
europepmc   +1 more source

TREM2 Drives Neutrophil Extracellular Traps‐Induced Dendritic Cell Maturation and Contributes to Lupus Progression

Advanced Science, Volume 13, Issue 7, 3 February 2026.
TREM2 recognizes NETs‐derived MPO to promote DC maturation and antigen presentation, thereby exacerbating the autoimmune response in SLE. Mechanistically, TREM2 activation triggers the DAP12/SYK/ERK cascade and enhances NETs internalization by DCs, which in turn activates the cGAS/STING signaling pathway.
Jingxian Shu, Jiabi Liang, Linda Zeng, Shuping Zhong, Xueling Fang, Yating Xu, Yongjian Wu, Xi Huang   +7 more
wiley   +1 more source

Cathepsin D promotes polarization of tumor-associated macrophages and metastasis through TGFBI-CCL20 signaling. [PDF]

Exp Mol Med
Lee SG, Woo SM, Seo SU, Lee CH, Baek MC, Jang SH, Park ZY, Yook S, Nam JO, Kwon TK.   +9 more
europepmc   +1 more source

NIR Ratiometric Fluorescent Antibody‐Drug Conjugate for Metastatic Ovarian Cancer Theranostics and Treatment Response Monitoring

Advanced Science, Volume 13, Issue 7, 3 February 2026.
In vivo optical imaging enhances antibody‐drug conjugate (ADC) optimization by enabling real‐time monitoring of stimulus‐responsive drug behavior. We report n501‐CYMMAF, a ratiometric theranostic with strong target affinity and low‐dose efficacy for ovarian metastasis.
Cheng Li, Zezhong Yu, Tao Pu, Yanling Wu, Gang Wang, Youhua Xie, Tianlei Ying, Zhenlin Yang, Yibing Shi   +8 more
wiley   +1 more source

Peptide and Drug‐Protected Gold Nanoclusters as Promising Biomaterials: Synthesis, Properties, and Applications

Aggregate, Volume 7, Issue 2, February 2026.
The integration of atomically precise gold nanoclusters with peptides or drugs represents a cutting‐edge class of nanomaterials in the biomedical field, owing to their unique physicochemical properties such as water solubility, excellent biocompatibility, low toxicity, and good renal clearance.
Rebeca Garcia Moura, M. Terêsa Machini, Rongchao Jin   +2 more
wiley   +1 more source

Prominent tauopathy and intracellular β-amyloid accumulation triggered by genetic deletion of cathepsin D: implications for Alzheimer disease pathogenesis. [PDF]

Alzheimers Res Ther
Terron HM, Parikh SJ, Abdul-Hay SO, Sahara T, Kang D, Dickson DW, Saftig P, LaFerla FM, Lane S, Leissring MA.   +9 more
europepmc   +1 more source

Engineering Ultrasound Contrast Agents for Targeted Therapeutics: A Theranostic Approach to Drug Delivery, Gene Therapy, and Immunomodulation

Advanced NanoBiomed Research, Volume 6, Issue 2, February 2026.
Ultrasound contrast agents, including microbubbles and nanobubbles, transform imaging and targeted therapy through precise engineering of size, shell composition, and surface properties. This review explores how these innovations enable tissue‐specific delivery, enhance therapeutic efficacy, and extend applications from vascular imaging to tumor ...
Ashkan Seza, Kimia Mozahheb Yousefi, Sara Minaeian   +2 more
wiley   +1 more source