Results 231 to 240 of about 113,729 (277)
Enhancement of Acetate-Induced Apoptosis of Colorectal Cancer Cells by Cathepsin D Inhibition Depends on Oligomycin A-Sensitive Respiration. [PDF]
BiomoleculesAlves S +5 more
europepmc +1 more source
ChemBioChem, Volume 27, Issue 5, 13 March 2026.The glycolipid‐peptide antigen complexes for self‐adjuvanting conjugates were successfully synthesized, and, with the HLA‐transgenic mice, the antigen‐specific CD8+ T cell expansion was exhibited. The results provide useful insights for the design and synthesis of vaccine conjugates using glycolipid antigen as an adjuvant.
Shunya Kikuchi +4 more
wiley +1 more source
Cathepsin D promotes polarization of tumor-associated macrophages and metastasis through TGFBI-CCL20 signaling. [PDF]
Exp Mol MedLee SG +9 more
europepmc +1 more source
Self‐Immolative Systems in Diagnostic and Therapeutic Applications
ChemMedChem, Volume 21, Issue 5, 13 March 2026.Self‐Immolative Systems enable the precise, residue‐free release of active molecules, drugs, probes, or sensors, via cyclization or elimination, triggered by specific stimuli. Their versatility drives advances in drug delivery, diagnostics, nanotechnology, materials chemistry, and biosensing, offering chemists control over molecular activation and ...
Windbedema Prisca Ouédraogo +2 more
wiley +1 more source
Mechanisms of parasite‐mediated disruption of brain vessels
FEBS Letters, Volume 600, Issue 5, Page 591-611, March 2026.Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source
Prominent tauopathy and intracellular β-amyloid accumulation triggered by genetic deletion of cathepsin D: implications for Alzheimer disease pathogenesis. [PDF]
Alzheimers Res TherTerron HM +9 more
europepmc +1 more source
Advanced Healthcare Materials, Volume 15, Issue 10, 13 March 2026.We present a strategy to enhance magnetic hyperthermia therapy by modulating nanoparticle–cell interactions. Antibody‐functionalized magnetic nanoparticles targeting the low‐internalizing CCR9 receptor enable spatially controlled membrane anchoring, reducing aggregation and maximizing heat generation under alternating magnetic fields.
David Egea‐Benavente +5 more
wiley +1 more source
Advanced Materials, Volume 38, Issue 16, 17 March 2026.We have developed an intracellular crystalline polymerization strategy involving acid‐catalyzed imine condensation to synthesize COFs in lysosomes. The generation of COFs in lysosomes damages their integrity, activates iron species, and induces immunogenic ferroptosis, thereby enhancing antitumor immunotherapy.
Qun Guan +5 more
wiley +1 more source
Advanced Science, Volume 13, Issue 16, 18 March 2026.PFOA exposure induces pregnancy loss by promoting glutaminolysis, which further causes ammonia accumulation in macrophages. Cellular ammonia retention results in damage to mitochondria and lysosomes, which leads to cell death eventually. Impaired lysosomes also decrease the secretion of the Cathepsin B (CTSB), and attenuate macrophage infiltration and ...
Yongbo Zhao +6 more
wiley +1 more source
Lnc-HIBADH-4 Regulates Autophagy-Lysosome Pathway in Amyotrophic Lateral Sclerosis by Targeting Cathepsin D. [PDF]
Mol NeurobiolHuang J +8 more
europepmc +1 more source