Results 21 to 30 of about 113,729 (277)
Expression of Antiangiogenic Prolactin Fragments in the Placentas of Women with Pregnancy Induced Hypertension [PDF]
, 2010 It has been reported that prolactin (PRL) is cleaved to 14 or 16 kDa fragments by cathepsin D in vitro and in vivo, and that such fragments exhibit antiangiogenic and proapoptotic properties.
Akahori, Yoichiro +4 more
core +1 more source
Folia Histochemica et Cytobiologica, 2008 Inhibitors of cathepsin D belong to chemical compounds that estrify carboxyl groups of the Asp33 and Asp231 residues of its catalytic site, penta-peptides containing statin, i.e. the amino acid similar in structure to the tetraedric indirect product, and
Łukasz Minarowski +3 more
doaj +1 more source
BMC Cancer, 2020 Background Malignant pleural effusion (MPE) causes substantial symptomatic burden in advanced malignancy. Although pleural fluid cytology is a commonly accepted gold standard of diagnosis, its low diagnostic yield is a challenge for clinicians.
Hayoung Choi, Yousang Ko, Chang Youl Lee
doaj +1 more source
A cardinal role for cathepsin d in co-ordinating the host-mediated apoptosis of macrophages and killing of pneumococci. [PDF]
PLoS Pathogens, 2011 The bactericidal function of macrophages against pneumococci is enhanced by their apoptotic demise, which is controlled by the anti-apoptotic protein Mcl-1.
Martin A Bewley +9 more
doaj +1 more source
Cathepsin D expression levels in nongynecological solid tumors: Clinical and therapeutic implications [PDF]
, 2004 Cathepsin D is a lysosomal acid proteinase which is involved in the malignant progression of breast cancer and other gynecological tumors. Clinical investigations have shown that in breast cancer patients cathepsin D overexpression was significantly ...
Crescimanno, M. +4 more
core +1 more source
FEBS Open Bio, 2021 Disruption of the mannose 6‐phosphate (M‐6‐P) pathway in HeLa cells by inactivation of the GNPTAB gene, which encodes the α/β subunits of GlcNAc‐1‐phosphotransferase, results in missorting of newly synthesized lysosomal acid hydrolases to the cell ...
Lin Liu, Balraj Doray
doaj +1 more source
Fluorogenic Substrates for Cathepsin D [PDF]
Bioscience, Biotechnology, and Biochemistry, 1999 Fluorogenic substrates for cathepsin D; A-Tyr-Phe(NO2)-Leu-Leu (A; Ala-Arg-Pro-Lys-Pro-Leu-Leu-, Arg-Pro-Lys-Pro-Leu-Leu-, Pro-Lys-Pro-Leu-Leu-, Lys-Pro-Leu-Leu-, Pro-Leu-Leu-) and B-Phe(NO2)-Tyr-Leu-Leu (B; Arg-Pro-Lys-Pro-Leu-Leu-, Pro-Lys-Pro-Leu-Leu-, Lys-Pro-Leu-Leu-, Pro-Leu-Leu-) (Phe(NO2), p-nitrophenylalanine) were synthesized and digested by ...
H, Yonezawa +3 more
openaire +2 more sources
Cathepsin D in a murine model of frontotemporal dementia with parkinsonism-linked to chromosome 17 [PDF]
, 2015 The final of publication is available at: http://dx.doi.org/10.3233/JAD-140456Tauopathies, such as Alzheimer’s disease (AD) and Frontotemporal dementia with Parkinsonism linked to chromosome 17 (FTDP-17), are characterized by tau accumulation.
Fernández-Montoya, Julia, Pérez, Mar
core +2 more sources
Epoxysuccinyl peptide-derived cathepsin B inhibitors: Modulating membrane permeability by conjugation with the C-terminal heptapeptide segment of penetratin [PDF]
, 2002 Besides its physiological role in lysosomal protein breakdown, extralysosomal cathepsin B has recently been implicated in apoptotic cell death. Highly specific irreversible cathepsin B inhibitors that are readily cellpermeant should be useful tools to ...
Assfalg-Machleidt, Irmgard +5 more
core +1 more source
Cathepsin D Expression in Colorectal Adenocarcinomas and Adenomas
The International Journal of Biological Markers, 2002 The aim of this study was to investigate the role of cathepsin D in colorectal cancer. For this purpose cathepsin D expression was evaluated by means of immunohistochemistry in stromal and tumor cells of 31 colorectal carcinomas and 29 adenomas ...
Y. Kanber +3 more
doaj +1 more source