Results 21 to 30 of about 66,677 (282)
Folia Histochemica et Cytobiologica, 2008 Inhibitors of cathepsin D belong to chemical compounds that estrify carboxyl groups of the Asp33 and Asp231 residues of its catalytic site, penta-peptides containing statin, i.e. the amino acid similar in structure to the tetraedric indirect product, and
Łukasz Minarowski +3 more
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FEBS Open Bio, 2021 Disruption of the mannose 6‐phosphate (M‐6‐P) pathway in HeLa cells by inactivation of the GNPTAB gene, which encodes the α/β subunits of GlcNAc‐1‐phosphotransferase, results in missorting of newly synthesized lysosomal acid hydrolases to the cell ...
Lin Liu, Balraj Doray
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Fluorogenic Substrates for Cathepsin D [PDF]
Bioscience, Biotechnology, and Biochemistry, 1999 Fluorogenic substrates for cathepsin D; A-Tyr-Phe(NO2)-Leu-Leu (A; Ala-Arg-Pro-Lys-Pro-Leu-Leu-, Arg-Pro-Lys-Pro-Leu-Leu-, Pro-Lys-Pro-Leu-Leu-, Lys-Pro-Leu-Leu-, Pro-Leu-Leu-) and B-Phe(NO2)-Tyr-Leu-Leu (B; Arg-Pro-Lys-Pro-Leu-Leu-, Pro-Lys-Pro-Leu-Leu-, Lys-Pro-Leu-Leu-, Pro-Leu-Leu-) (Phe(NO2), p-nitrophenylalanine) were synthesized and digested by ...
H, Yonezawa +3 more
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Cathepsin E (EC 3.4.23.34) — a review
Folia Histochemica et Cytobiologica, 2012 Cathepsin E belongs to the third class of enzymes — hydrolases, a subclass of peptide bond hydrolases and a sub-subclass of endopeptidases with aspartic catalytic sites. Cathepsin E is an endopeptidase with substrate specificity similar to that
Anna Worowska +3 more
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Lysosome-Disrupting Agents in Combination with Venetoclax Increase Apoptotic Response in Primary Chronic Lymphocytic Leukemia (CLL) Cells Mediated by Lysosomal Cathepsin D Release and Inhibition of Autophagy. [PDF]
CellsManivannan MS +5 more
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Frontiers in Surgery, 2018 AimWe have previously identified and characterized cancer stem cell (CSC) subpopulations in liver metastasis from colon adenocarcinoma (LMCA). In this study we investigated the expression and localization of cathepsins B, D and G, in relation to these ...
Shreeja Mehrotra +9 more
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Identification of Cathepsin D as a Plasma Biomarker for Alzheimer’s Disease
Cells, 2021 Although Alzheimer’s disease (AD) is the most common neurodegenerative disease, there are still no drugs available to treat or prevent AD effectively.
Jae-Whan Kim +9 more
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Neurobiology of Disease, 2009 Neuronal ceroid lipofuscinoses (NCLs) are pediatric, neurodegenerative, lysosomal storage disorders. Mutations in cathepsin D result in the most severe, congenital form of NCLs. We have previously generated a cathepsin D deficient Drosophila model, which
Mervi Kuronen +3 more
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Applied Sciences, 2022 The association of cathepsin proteases in neurobiology is increasingly recognized. Our previous studies indicated that cathepsin-K-deficient (Ctsk−/−) mice have learning and memory impairments.
Denise M. T. Yu +6 more
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THE IMMUNOCYTOCHEMICAL DEMONSTRATION OF CATHEPSIN D [PDF]
Journal of Histochemistry & Cytochemistry, 1972 Cathepsin D has been demonstrated for the first time using an immunocytochemical approach and fluorescence microscopy. It has been localized in chick epithelium-like cells and in cells of synovia from joints of rabbits with an experimental arthritis. The enzyme is associated with lysosome-like organelles: it also has a diffuse cytoplasmic distribution
A R, Poole, J T, Dingle, A J, Barrett
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