Results 11 to 20 of about 114,831 (298)

Lysosomal dysfunction promotes cleavage and neurotoxicity of tau in vivo. [PDF]

PLoS Genetics, 2010
Expansion of the lysosomal system, including cathepsin D upregulation, is an early and prominent finding in Alzheimer's disease brain. Cell culture studies, however, have provided differing perspectives on the lysosomal connection to Alzheimer's disease,
Vikram Khurana, Ilan Elson-Schwab, Tudor A Fulga, Katherine A Sharp, Carin A Loewen, Erin Mulkearns, Jaana Tyynelä, Clemens R Scherzer, Mel B Feany   +8 more
doaj   +1 more source

The behavior of cathepsin D during milk processing and its contribution to bitterness in a model fresh cheese

Journal of Dairy Science, 2023
: The bovine endopeptidase cathepsin D was investigated regarding its temperature-dependent inactivation and ability to form bitter peptides within a spiked model fresh cheese.
Gudrun Horstmann, Johannes Schäfer, Melanie Rosenberger, Ines Seitl, Jörg Hinrichs, Lutz Fischer   +5 more
doaj   +1 more source

Effect of heavy metal cations on the activity of cathepsin D (in vitro study) Effect of heavy metal cations on the activity of cathepsin D (in vitro study)

Folia Histochemica et Cytobiologica, 2012
We studied the effect of heavy metal cations: Fe 2+, Cu2+, Zn2+, Cd2+, Hg2+, Pb2+ on the activity of<br />cathepsin D in human aorta homogenate and blood serum. The concentration of cations was 1 mmol/l.
Alicja Karwowska, Radosław Łapiński, Marek Gacko, Ewa Grzegorczyk, Joanna Żurawska, Jan K. Karczewski   +5 more
doaj   +1 more source

The Role of Cathepsin D in the Pathophysiology of Heart Failure and its Potentially Beneficial Properties:a translational approach [PDF]

, 2019
Aims: Cathepsin D is a ubiquitous lysosomal protease that is primarily secreted due to oxidative stress. The role of circulating cathepsin D in heart failure (HF) is unknown.
Adriaan A. Voors, Chim C. Lang, Diment S, Dirk J. Veldhuisen, Hans Hillege, Jasper Tromp, Leong L. Ng, Marco Metra, Martijn F. Hoes, Nilesh J. Samani, Nils Bomer, Peter Meer, Pim Harst, Pol A, Silke U. Oberdorf‐Maass, Stefan D. Anker, Wouter Ouwerkerk   +16 more
core   +3 more sources

Haematopoietic development and immunological function in the absence of cathepsin D

BMC Immunology, 2007
Background Cathepsin D is a well-characterized aspartic protease expressed ubiquitously in lysosomes. Cathepsin D deficiency is associated with a spectrum of pathologies leading ultimately to death.
Saftig Paul, Grosvenor Nicholas, Novelli Marco, Uchiyama Yasuo, Tulone Calogero, Chain Benjamin M   +5 more
doaj   +1 more source

Immunoradiometric assay of cathepsin D: Estrogen regulated vs. non estrogen- regulated cathepsin D expression in relation to clinicopathological features of breast cancer [PDF]

Archive of Oncology, 2002
Background: Cellular biomarkers may predict tumor cell behavior in breast cancer. One of the most paradoxical biomarker in breast cancer is cathepsin D.
Nikolić-Vukosavljević Dragica, Markičević Milan, Kanjer Ksenija, Raković-Todorović Nataša, Nešković-Konstantinović Zora   +4 more
doaj   +1 more source

Glucocerebrosidase activity, cathepsin D and monomeric α-synuclein interactions in a stem cell derived neuronal model of a PD associated GBA1 mutation

Neurobiology of Disease, 2020
The presence of GBA1 gene mutations increases risk for Parkinson's disease (PD), but the pathogenic mechanisms of GBA1 associated PD remain unknown. Given that impaired α-synuclein turnover is a hallmark of PD pathogenesis and cathepsin D is a key enzyme
Shi-yu Yang, Matthew Gegg, David Chau, Anthony Schapira   +3 more
doaj   +1 more source

Expression of Antiangiogenic Prolactin Fragments in the Placentas of Women with Pregnancy Induced Hypertension [PDF]

, 2010
It has been reported that prolactin (PRL) is cleaved to 14 or 16 kDa fragments by cathepsin D in vitro and in vivo, and that such fragments exhibit antiangiogenic and proapoptotic properties.
Akahori, Yoichiro, Hiramatsu, Yuji, Masumoto, Akio, Masuyama, Hisashi, Takamoto, Norio   +4 more
core   +1 more source

Cathepsin D inhibitors.

Folia Histochemica et Cytobiologica, 2008
Inhibitors of cathepsin D belong to chemical compounds that estrify carboxyl groups of the Asp33 and Asp231 residues of its catalytic site, penta-peptides containing statin, i.e. the amino acid similar in structure to the tetraedric indirect product, and
Łukasz Minarowski, Alicja Karwowska, Alina Minarowska, Marek Gacko   +3 more
doaj   +1 more source

Pro-cathepsin D as a diagnostic marker in differentiating malignant from benign pleural effusion: a retrospective cohort study

BMC Cancer, 2020
Background Malignant pleural effusion (MPE) causes substantial symptomatic burden in advanced malignancy. Although pleural fluid cytology is a commonly accepted gold standard of diagnosis, its low diagnostic yield is a challenge for clinicians.
Hayoung Choi, Yousang Ko, Chang Youl Lee
doaj   +1 more source