Results 41 to 50 of about 114,831 (298)

Vacuolating cytotoxin and variants in Atg16L1 that disrupt autophagy promote Helicobacter pylori infection in humans [PDF]

, 2012
Peer ...
Alberto Delgado, Amieva, Argent, Barrett, Cathy Streutker, Dana J. Philpott, Deepa Raju, Deretic, El-Omar, Emad El Omar, Erdmutte Kunstmann, Esther Galindo–Mata, Franco, Georgina Hold, Gonzalez, Gutierrez, Heidi Mascarenhas, Iwamaru, Jia, Judith Romero–Gallo, Kimura, Kirkegaard, Kuballa, Lapaquette, Levine, Luther, Luther, Mahendra Singh Ramjeet, Maiuri, Mark S. Silverberg, Mathew, Mathew, Mauricio R. Terebiznik, Michal Sibony, Michelle Ang, Mortimore, Moscat, Nicola L. Jones, Ogawa, Ogawa, Orvedahl, Pelayo Correa, Polk, Richard M. Peek, Rioux, Saitoh, Satin, Scott, Seamus Hussey, Stephen E. Girardin, Steven R. Blanke, Tamotsu Yoshimori, Tanida, Terebiznik, Terebiznik, Travassos, Vijay Gupta, Wang, White, Yoshimori, Zheng, Zheng   +61 more
core   +1 more source

Estrogen-regulated proteins cathepsin D and pS2 in breast carcinoma [PDF]

Archive of Oncology, 2006
In addition to classical prognostic/predictive factors, significant biological markers have been identified to provide potentially relevant information regarding natural or clinical course of breast cancer.
Markićević Milan, Vujasinović Tijana, Nešković-Konstantinović Zora, Nikolić-Vukosavljević Dragica   +3 more
doaj   +1 more source

Identification of new biomarkers for sarcopenia and characterization of cathepsin D biomarker

JCSM Rapid Communications, 2021
Background Sarcopenia is the progressive generalized loss of skeletal muscle mass, strength, and function that occurs with aging. This study was undertaken to identify new biomarkers of sarcopenia by proteomics analysis of female sera.
Corine L'hôte, Benoît Cordier, Alain Labasse, Christelle Boileau, Bérénice Costes, Yves Henrotin   +5 more
doaj   +1 more source

The Specificity of Cathepsin D

Journal of Biological Chemistry, 1973
Abstract Bovine spleen cathepsin D has been partially purified for studies of its specificity. Isoelectric focusing of the purest preparation obtained indicated the presence of three molecular forms having approximately the same specific activity, but differing in their isoelectric points.
J B, Ferguson, J R, Andrews, I M, Voynick, J S, Fruton   +3 more
openaire   +2 more sources

Synthesis and Evaluation of New Cathepsin D Inhibitors [PDF]

, 2005
Cathepsin D, a lysosomal aspartic protease, has been suggested to play a role in the metastatic potential of several types of cancer A high activated cathepsin D level in breast tumor tissue has been associated with an increased incidence of relapse and ...
Godwin, Walter E., Green, Adam, Hatfield, Susan E., McConnell, Matthew, McConnell, Rose M., Sayyer, Kelley, Trana, Carol, Young, Ashley, Young, Lauren   +8 more
core   +1 more source

The role of proteases in pathologies of the synovial joint [PDF]

, 2008
Synovial (diarthrodial) joints are employed within the body to provide skeletal mobility and have a characteristic structure adapted to provide a smooth almost frictionless surface for articulation.
Buttle, D, Jones, GC, Riley, GP
core   +1 more source

Smart, Bio‐Inspired Polymers and Bio‐Based Molecules Modified by Zwitterionic Motifs to Design Next‐Generation Materials for Medical Applications

Advanced Functional Materials, EarlyView.
Bio‐based and (semi‐)synthetic zwitterion‐modified novel materials and fully synthetic next‐generation alternatives show the importance of material design for different biomedical applications. The zwitterionic character affects the physiochemical behavior of the material and deepens the understanding of chemical interaction mechanisms within the ...
Theresa M. Lutz, Jonas De Breuck, Sahar Salehi, Meike N. Leiske   +3 more
wiley   +1 more source

Evaluation of serum cathepsin D concentrations in coronary artery disease

Indian Heart Journal, 2018
Background: Coronary artery disease (CAD) cannot be sufficiently explained by the presence of traditional risk factors. Cathepsin D has been proposed to serve as a surrogate marker of atherosclerosis but its alterations in CAD patients have not been ...
Amir Hooshang Mohammadpour, Zakieh Salehinejad, Sepideh Elyasi, Mohsen Mouhebati, Seyed Reza Mirhafez, Sara Samadi, Majid Ghayour-Mobarhan, Gordon Ferns, Amirhossein Sahebkar   +8 more
doaj   +1 more source

The Role of DmCatD, a Cathepsin D-Like Peptidase, and Acid Phosphatase in the Process of Follicular Atresia in Dipetalogaster maxima (Hemiptera: Reduviidae), a Vector of Chagas' Disease [PDF]

, 2015
In this work, we have investigated the involvement of DmCatD, a cathepsin D-like peptidase, and acid phosphatase in the process of follicular atresia of Dipetalogaster maxima, a hematophagous insect vector of Chagas' disease. For the studies, fat bodies,
Canavoso, Lilian Etelvina, Fruttero, Leonardo Luis, Leyria, Jimena, Nazar, Magalí   +3 more
core   +3 more sources

Activation of cathepsin D by glycosaminoglycans [PDF]

The FEBS Journal, 2009
We have previously shown that heparin can increase the activity of the proenzyme form of Alzheimer’s β‐site amyloid precursor protein cleaving enzyme 1 (BACE1). Cathepsin D (CD) is a member of the aspartic protease family and has sequence similarity to BACE1.
Beckman, Marie, Freeman, Craig, Small, David H, Parish, Christopher   +3 more
openaire   +3 more sources