Results 41 to 50 of about 113,729 (277)

Cathepsin K deficiency in mice induces structural and metabolic changes in the central nervous system that are associated with learning and memory deficits [PDF]

, 2011
Background Cathepsin K is a cysteine peptidase known for its importance in osteoclast-mediated bone resorption. Inhibitors of cathepsin K are in clinical trials for treatment of osteoporosis.
Stephanie Dauth, Ruxandra F Sîrbulescu, Silvia Jordans, Maren Rehders, Linda Avena, Julia Oswald, Alexander Lerchl, Paul Saftig, Klaudia Brix   +8 more
core   +1 more source

Estrogen-regulated proteins cathepsin D and pS2 in breast carcinoma [PDF]

Archive of Oncology, 2006
In addition to classical prognostic/predictive factors, significant biological markers have been identified to provide potentially relevant information regarding natural or clinical course of breast cancer.
Markićević Milan, Vujasinović Tijana, Nešković-Konstantinović Zora, Nikolić-Vukosavljević Dragica   +3 more
doaj   +1 more source

The role of proteases in pathologies of the synovial joint [PDF]

, 2008
Synovial (diarthrodial) joints are employed within the body to provide skeletal mobility and have a characteristic structure adapted to provide a smooth almost frictionless surface for articulation.
Buttle, D, Jones, GC, Riley, GP
core   +1 more source

The Specificity of Cathepsin D

Journal of Biological Chemistry, 1973
Abstract Bovine spleen cathepsin D has been partially purified for studies of its specificity. Isoelectric focusing of the purest preparation obtained indicated the presence of three molecular forms having approximately the same specific activity, but differing in their isoelectric points.
J B, Ferguson, J R, Andrews, I M, Voynick, J S, Fruton   +3 more
openaire   +2 more sources

Morphologic and functional correlates of synaptic pathology in the cathepsin D knockout mouse model of congenital neuronal ceroid lipofuscinosis [PDF]

, 2011
Mutations in the cathepsin D (CTSD) gene cause an aggressive neurodegenerative disease (congenital neuronal ceroid lipofuscinosis) that leads to early death. Recent evidence suggests that presynaptic abnormalities play a major role in the pathogenesis of
Andrew Edwards, Ann K. Wright, Belly, Cepeda, Garborg, Jaana Tyynelä, Jonathan D. Cooper, Klapstein, Koike, Sabine Koch, Saftig, Svetlana M. Molchanova, Thomas H. Gillingwater, Tomi Taira   +13 more
core   +1 more source

Identification of new biomarkers for sarcopenia and characterization of cathepsin D biomarker

JCSM Rapid Communications, 2021
Background Sarcopenia is the progressive generalized loss of skeletal muscle mass, strength, and function that occurs with aging. This study was undertaken to identify new biomarkers of sarcopenia by proteomics analysis of female sera.
Corine L'hôte, Benoît Cordier, Alain Labasse, Christelle Boileau, Bérénice Costes, Yves Henrotin   +5 more
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Evaluation of serum cathepsin D concentrations in coronary artery disease

Indian Heart Journal, 2018
Background: Coronary artery disease (CAD) cannot be sufficiently explained by the presence of traditional risk factors. Cathepsin D has been proposed to serve as a surrogate marker of atherosclerosis but its alterations in CAD patients have not been ...
Amir Hooshang Mohammadpour, Zakieh Salehinejad, Sepideh Elyasi, Mohsen Mouhebati, Seyed Reza Mirhafez, Sara Samadi, Majid Ghayour-Mobarhan, Gordon Ferns, Amirhossein Sahebkar   +8 more
doaj   +1 more source

Activation of cathepsin D by glycosaminoglycans [PDF]

The FEBS Journal, 2009
We have previously shown that heparin can increase the activity of the proenzyme form of Alzheimer’s β‐site amyloid precursor protein cleaving enzyme 1 (BACE1). Cathepsin D (CD) is a member of the aspartic protease family and has sequence similarity to BACE1.
Beckman, Marie, Freeman, Craig, Small, David H, Parish, Christopher   +3 more
openaire   +3 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source