Results 71 to 80 of about 66,677 (282)
Detection of cathepsin D in ewe’s milk by Western Blotting method
Mljekarstvo, 2013 Milk contains about 70 indogene enzymes, while only twenty of them were investigated. One of the less explored is the milk enzyme cathepsin D, proteolytic enzyme located in the lysosomes, which are an integral part of the somatic cells whose number ...
Iva Dolenčić Špehar +5 more
doaj
Cathepsin D-deficient Drosophila recapitulate the key features of neuronal ceroid lipofuscinoses
Neurobiology of Disease, 2005 Neuronal ceroid lipofuscinoses (NCLs) are a group of lysosomal storage disorders characterized pathologically by neuronal accumulation of autofluorescent storage material and neurodegeneration. An ovine NCL form is caused by a recessive point mutation in
Liisa Myllykangas +5 more
doaj +1 more source
Advanced Science, EarlyView.Integrated scRNA‐seq, scTCR‐seq analysis, and functional assays identify PRDM1+ malignant epithelial cells with hyper lipid peroxidation characteristics that demonstrate reduced responsiveness to the nICRT treatment. Principal factor PRDM1 activates cysteine metabolism genes to modulate lipid peroxidation (an intrinsic cellular pathway related to ...
Dijian Shen +12 more
wiley +1 more source
Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy
Advanced Science, EarlyView.Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong +5 more
wiley +1 more source
Advanced Science, EarlyView.IL‐4/IL‐13/STAT6 signaling plays a crucial for the suppression of pro‐inflammation during acute pancreatitis and supports acinar cell regeneration but has only minor impact on fibrogenesis during chronic form of the disease. IL‐4/IL‐13 induce the expression of certain collagens directly in pancreatic fibroblasts via STAT6 activation, whereas ...
ElSheikh H +13 more
wiley +1 more source
Advanced Science, EarlyView.This study demonstrates that how hollow‐channel scaffolds promote vascularized bone regeneration via an immunomodulatory mechanism. The channel structures facilitate the formation of a neutrophil extracellular traps‐fibrin scaffold that recruits vascular endothelial growth factor A (VEGF‐A)‐secreting M2 macrophages to drive angiogenesis. Combining this
Guifang Wang +8 more
wiley +1 more source
The International Journal of Biological Markers, 1996 The aim of this study was the survey of cathepsin D determination in a large group of patients enrolled at several centers, under the coordination of the Italian Committee for Quality Control in the Oncological Laboratory.
D. Pelizzola +20 more
doaj +1 more source
Stimuli‐Responsive Supramolecular Biomaterials for Cancer Theranostics
Advanced Science, EarlyView.The ultimate goal of cancer theranostics is to get imaging agents and therapeutic cargo to tumor sites when and where they are required. “Smart” systems should be developed. This review discusses the characteristics of physiological stimuli, types and action modes of external stimuli, construction approaches and working principles, as well as ...
Wenting Hu +4 more
wiley +1 more source
Cancer Biology & Therapy, 2010 Proteases are a large and important group of enzymes, with essential roles in a great diversity of biological processes in all living organisms.1 Proteases are classified according the mechanisms by which they catalyze hydrolysis of peptide bonds within their protein substrates: serine, cysteine, threonine, metallo- and aspartic protease classes are ...
openaire +2 more sources
Cathepsin D inhibitors based on tasiamide B derivatives with cell membrane permeability
, 2022 Zhi Li +4 more
openalex +1 more source