Results 71 to 80 of about 114,831 (298)
Cathepsin D in Breast Cancer Tissue
The International Journal of Biological Markers, 1990 The cathepsin D concentration in 18 women with benign breast pathology has a cut-off value of 43 pmol/mg of protein. High values have been detected in two cases of chronic mastitis. These high values of cathepsin D were found in a study of 62 patients suffering from breast cancer and are independent of the hormone dependent state of the tumour.
P, Gonzalez Gancedo +6 more
openaire +2 more sources
Advanced Science, EarlyView.Antibody–drug conjugates (ADCs) transform breast cancer therapy, yet resistance limits their durability. Emerging evidence reveals that ADC failure is not solely tumor‐intrinsic but shaped by dynamic tumor–microenvironment interactions that alter drug delivery, processing, and response.
Minji Seo, Jangsoon Lee, Naoto T. Ueno
wiley +1 more source
Lysosomal proteases are involved in generation of N-terminal huntingtin fragments
Neurobiology of Disease, 2006 N-terminal mutant huntingtin (N-mhtt) fragments form inclusions and cause cell death in vitro. Mutant htt expression stimulates autophagy and increases levels of lysosomal proteases. Here, we show that lysosomal proteases, cathepsins D, B and L, affected
Yun J. Kim +9 more
doaj +1 more source
A Novel Combination Therapy Approach Targeting STAT3 and Autophagy in Glioblastoma
Autophagy Reports, 2022 The aggressive brain cancer glioblastoma (GBM) is notoriously resistant to radiotherapy and chemotherapy, which drives tumor recurrence and relapse. GBM cells are highly addicted to STAT3 (signal transducer and activator of transcription 3) and STAT3 ...
Sujoy Bhattacharya +2 more
doaj +1 more source
Protease inhibitors targeting coronavirus and filovirus entry. [PDF]
, 2015 In order to gain entry into cells, diverse viruses, including Ebola virus, SARS-coronavirus and the emerging MERS-coronavirus, depend on activation of their envelope glycoproteins by host cell proteases.
Agudelo, Juliet +10 more
core +1 more source
Localized NF‐κB Inhibition Reduces Lipid Nanoparticle‐Associated Inflammation
Advanced Science, EarlyView.Lipid nanoparticles (LNPs) activate NF‐κB and provoke inflammation that limits therapeutic delivery. By encapsulating selective NF‐κB inhibitors within LNPs, localized suppression of inflammatory signaling is achieved without compromising mRNA expression.
Carolann L. Espy +16 more
wiley +1 more source
Conformation and processing of cathepsin D
Bioscience Reports, 1985 Cathepsin D occurs in two forms, a single polypeptide chain (Mr 44000) and a non-covalent complex of two peptides of Mr 14000 and 30000 that is derived by proteolytic processing of the 44000 polypeptide. The two forms from bovine spleen are closely similar in secondary structure content, in aromatic amino acid environment and in the two step ...
R H, Pain, T, Lah, V, Turk
openaire +2 more sources
Macrophage Extracellular Traps in Immunity and Cancer
Advanced Science, EarlyView.As a macrophage‐mediated innate defense mechanism, the dysregulated release of METs drives chronic inflammation and influences tumor progression. Furthermore, METs exhibit a functional duality within the tumor microenvironment, capable of both promoting and suppressing tumor development.
Junyao Li +5 more
wiley +1 more source
Molecular Cancer, 2010 Background Cathepsins represent a group of proteases involved in determining the metastatic potential of cancer cells. Among these are cysteinyl- (e.g. cathepsin B and cathepsin L) and aspartyl-proteases (e.g.
Matarrese Paola +9 more
doaj +1 more source
Inhibition of MAPK-Erk pathway in vivo attenuates aortic valve disease processes in Emilin1-deficient mouse model [PDF]
, 2017 Aortic valve disease (AVD) is a common condition with a progressive natural history, and presently, there are no pharmacologic treatment strategies. Elastic fiber fragmentation (EFF) is a hallmark of AVD, and increasing evidence implicates developmental ...
Aikawa +45 more
core +2 more sources