Cathepsin E deficiency impairs autophagic proteolysis in macrophages. [PDF]
PLoS ONE, 2013 Cathepsin E is an endosomal aspartic proteinase that is predominantly expressed in immune-related cells. Recently, we showed that macrophages derived from cathepsin E-deficient (CatE(-/-)) mice display accumulation of lysosomal membrane proteins and ...
Takayuki Tsukuba +7 more
doaj +5 more sources
A two‐sample Mendelian randomization study and mediation analysis exploring the link between cathepsins and epilepsy [PDF]
Epilepsia OpenObjective This study aims to investigate the causal relationship between cathepsins and epilepsy, using Mendelian randomization (MR) and mediation analysis.
Huaiyu Sun +7 more
doaj +2 more sources
Cathepsin E promotes pulmonary emphysema via mitochondrial fission. [PDF]
Am J Pathol, 2014 Emphysema is characterized by loss of lung elasticity and irreversible air space enlargement, usually in the later decades of life. The molecular mechanisms of emphysema remain poorly defined. We identified a role for a novel cathepsin, cathepsin E, in promoting emphysema by inducing mitochondrial fission. Unlike previously reported cysteine cathepsins,
Zhang X +6 more
europepmc +3 more sources
Pancreatic cancer-associated Cathepsin E as a drug activator. [PDF]
J Control Release, 2013 Pancreatic ductal adenocarcinoma (PDAC) is challenging to treat, and better means to detect and/or treat pancreatic cancer are urgently needed to save lives. Cathepsin E (Cath E) is a proteolytic enzyme highly expressed in PDAC. In this study, a novel approach using Cath E activation of a Cath E-specific prodrug was demonstrated. Specific activation of
Abd-Elgaliel WR +4 more
europepmc +4 more sources
The Homology Modeling and Docking Investigation of Human Cathepsin B [PDF]
International Journal of Medical Toxicology and Forensic Medicine, 2020 Background: Cathepsin B comprises a group of lysosomal cysteine proteases belonging to the Papain family; it has an intracellular function in the process of protein catabolism, antigen processing in the immune response, and Alzheimer’s disease.
Afshin Khara +2 more
doaj +1 more source
Eimeripain, a cathepsin B-like cysteine protease, expressed throughout sporulation of the apicomplexan parasite Eimeria tenella. [PDF]
PLoS ONE, 2012 The invasion and replication of Eimeria tenella in the chicken intestine is responsible for avian coccidiosis, a disease that has major economic impacts on poultry industries worldwide. E.
Anaïs Rieux +7 more
doaj +1 more source
Cathepsin E (EC 3.4.23.34) — a review
Folia Histochemica et Cytobiologica, 2012 Cathepsin E belongs to the third class of enzymes — hydrolases, a subclass of peptide bond hydrolases and a sub-subclass of endopeptidases with aspartic catalytic sites. Cathepsin E is an endopeptidase with substrate specificity similar to that
Anna Worowska +3 more
doaj +1 more source
Factors influencing the measurement of lysosomal enzymes activity in human cerebrospinal fluid. [PDF]
PLoS ONE, 2014 Measurements of the activities of lysosomal enzymes in cerebrospinal fluid have recently been proposed as putative biomarkers for Parkinson's disease and other synucleinopathies.
Emanuele Persichetti +11 more
doaj +1 more source
Causal association of cathepsins with female infertility: a bidirectional Mendelian randomization analysis [PDF]
Obstetrics & Gynecology ScienceObjective This study aimed to systematically evaluate potential causal relationships between nine cathepsins and female infertility using Mendelian randomization (MR) methods.
Lidan Liu +5 more
doaj +1 more source
Co-depletion of cathepsin B and uPAR induces G0/G1 arrest in glioma via FOXO3a mediated p27 upregulation. [PDF]
PLoS ONE, 2010 BackgroundCathepsin B and urokinase plasminogen activator receptor (uPAR) are both known to be overexpressed in gliomas. Our previous work and that of others strongly suggest a relationship between the infiltrative phenotype of glioma and the expression ...
Sreelatha Gopinath +8 more
doaj +1 more source