Results 11 to 20 of about 60,305 (241)
Stabilisation of cathepsin E by ATP [PDF]
FEBS Letters, 1989 The hydrolysis of 3 distinct substrates by cathepsin E from human red blood cells and gastric mucosa was measured in the presence and absence of physiologically relevant concentrations of ATP. At pH values below about 5.0, the nucleotide was without effect.
Thomas, D.J. +7 more
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FEBS Letters, 1995 Cathepsin E is a homodimer, consisting of two monomers linked by an inter‐molecular disulphide bond. The cysteine residue involved is located near to the N‐terminus of the mature proteinase. By mutating this residue to alanine, a monomeric form of human cathepsin E was engineered and purified.
Fowler, Sylvia D. +3 more
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An immunohistochemical study and review of potential markers of human intestinal M cells
European Journal of Histochemistry, 2009 M cells are found in intestinal follicle associated epithelium. Studies into the physiological and pathological roles of human M cells have been hampered by the lack of well-substantiated, specific markers for these cells.
NACS Wong, M Herriot, F Rae
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Mediators of Inflammation, 2009 Cathepsin G is a serine protease secreted by activated neutrophils that play a role in the inflammatory response. Because neutrophils are known to be invading leukocytes in various tumors, their products may influence the characteristics of tumor cells ...
Tomoya Kudo +5 more
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New Functional Aspects of Cathepsin D and Cathepsin E
Molecules and Cells, 2000 Cathepsin D (CD) and cathepsin E are representative lysosomal and nonlysosomal aspartic proteinases, respectively, and play an important role in the degradation of proteins, the generation of bioactive proteins, antigen processing, etc. Recenty, several lines of evidence have suggested the involvement of these two enzymes in the execution of neuronal ...
T, Tsukuba +5 more
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Respiratory Research, 2011 Background Remodeling of lung tissues during the process of granuloma formation requires significant restructuring of the extra-cellular matrix and cathepsins K, L and S are among the strongest extra-cellular matrix degrading enzymes.
Percival M David +3 more
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Atopic dermatitis and cathepsin E
Folia Pharmacologica Japonica, 2003 Cathepsin E is an intracellular aspartic proteinase expressed predominantly in immune cells and skin. We show that cathepsin E-deficient mice spontaneously develop atopic dermatitis (AD)-like skin lesions comparable to human AD when kept under conventional circumstances, but not under specific pathogen-free conditions.
Takayuki, Tsukuba, Kenji, Yamamoto
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Human cathepsin E produced in E. coli
FEBS Letters, 1993 A cDNA for procathepsin E was generated from human gastric adenocarcinoma (AGS) cells, amplified by PCR and inserted into the T7 dependent vector pET 22b for expression in E. coli. Purification of the resultant product was accomplished simply, without the need to resort to column chromatography.
Hill, Jeffrey +2 more
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Selective detection of Cathepsin E proteolytic activity [PDF]
Biochimica et Biophysica Acta (BBA) - General Subjects, 2010 Aspartic proteases Cathepsin (Cath) E and D are two different proteases, but they share many common characteristics, including molecular weight, catalytic mechanism, substrate preferences, proteolytic conditions and inhibition susceptibility. To define the biological roles of these proteases, it is necessary to elucidate their substrate specificity. In
Wael R, Abd-Elgaliel, Ching-Hsuan, Tung
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Mediators of Inflammation, 2014 We previously found that a neutrophil serine protease, cathepsin G, weakens adherence to culture substrates and induces E-cadherin-dependent aggregation of MCF-7 human breast cancer cells through its protease activity.
Satoru Yui +3 more
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