Results 221 to 230 of about 60,305 (241)
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Cathepsin E Expressed in Pancreatic Cancer
1995The aspartic proteinase family, each member of which has two essential aspartyl residues at the active site, includes pepsins, renin, cathepsin D, and cathepsin E (CTSE). Unlike pepsins, CTSE is a non-secretory, intracellular, but non-lysosomal proteinase found in the highest concentration in the superficial epithelial cells of the stomach (1,2).
T, Azuma +6 more
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Immunohistochemical and Immunocytochemical Localization of Cathepsin E Compared with Cathepsin D
1991Recent reports have suggested that cathepsin E is a non-lysosomal aspartic proteinase and that this enzyme participates in extralysosomal proteolysis.1–3 Although its enzymatic and structural properties have been demonstrated,4–7 its physiological function is still unknown.
H, Sakai, T, Saku, Y, Kato, K, Yamamoto
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Immunochemical Difference between Cathepsin D and Cathepsin E-Like Enzyme from Rat Spleen
The Journal of Biochemistry, 1980The immunological properties of acid proteinases from rat spleen, two types of cathepsin D and a cathepsin E-like enzyme, were examined. The rabbit antiserum was prepared against the major form of cathepsin D (cathepsin D-I) from rat spleen. The antiserum quantitatively precipitated the enzyme activity from the purified cathepsin D-I preparation.
K, Yamamoto +3 more
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Biological Significance and Activity Control of Cathepsin E Compared with Cathepsin D
1991Protein degradation in mammalian cells is thought to occur via two major pathways: a lysosomal and a non-lysosomal pathway. The former may participate in degradation of the majority of cellular proteins nonspecifically and the latter may preferentially degrade abnormal and short-lived proteins.1 Recently, a number of non-lysosomal proteinases, such as ...
K, Yamamoto, H, Sakai, E, Ueno, Y, Kato
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Cathepsin E as a Marker of Colon Cancer
2023Elevated levels of cathepsin E (catE) are demonstrated to be diagnostic of intestinal forms of cancer, such as colorectal cancer. Elevated levels of cathepsin E (catE, monomeric forms) are demonstrated to be detectable in the urine of animals having colorectal cancer, and a diagnostic/screening method for identifying and/or detecting colorectal cancer ...
Castellino, Francis J. +2 more
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Cathepsin E and Cathepsin D: Biosynthesis, Processing and Subcellular Location
1995Intracellular protein turnover occurs via two major pathways, lysosomal and nonlysosomal proteolytic pathways. Cathepsins D (CD) and E (CE) are two major intracellular aspartic proteinases in mammalian cells. Besides their structural and immunological distinction (1–5), they are different in both tissue distribution and intracellular localization (4, 6)
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Cathepsin E in the Central Nervous System
1998There is growing evidence that altered intracellular proteolytic system is closely associated with different neuropathological conditions in the central nervous system. Irregular proteolysis of physiologically important neuronal proteins is thought to have severe consequence for the integrity of neuronal structure and function and the disorder or ...
H, Nakanishi, K, Yamamoto
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Purification and Characterization of Recombinant Human Cathepsin E
1995The human cathepsin E was purified from the culture supernatant of Pichia pastoris strain transformed with a human cathepsin E expression plasmid. Purification was performed by a three-step procedure, TSKgel Phenyl-5PW, Toyopearl HW55S and TSKgel DEAE-5PW column chromatographies.
H, Iida +6 more
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Cathepsin E as a Potent Anticancer Protease
Journal of Oral Biosciences, 2011Cathepsin E (CatE), an endolysosomal aspartic protease, is predominantly expressed in cells of the immune system, and CatE-deficient mice exhibit phenotypes affecting immune responses; however, the precise role of this enzyme remains speculative. In this review, some of the knowledge obtained from a study of CatE functions in host defense against tumor
Tomoyo Kawakubo +3 more
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Modeling the tertiary structure of human cathepsin-E
Biochemical and Biophysical Research Communications, 2005Cathepsin-E is an endolysosomal aspartic proteinase and is predominantly expressed in immune system cells. Deficiency of cathepsin-E is associated with the development of atopic dermatitis, a pruritic inflammatory skin disease, which has put us to face a high selectivity challenge in the development of drugs for the therapy of Alzheimer's disease or ...
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