Results 21 to 30 of about 60,305 (241)
Correction: Cathepsin E Deficiency Impairs Autophagic Proteolysis in Macrophages. [PDF]
PLoS ONE, 2014 doaj +4 more sources
Glucosamine prevents polarization of cytotoxic granules in NK-92 cells by disturbing FOXO1/ERK/paxillin phosphorylation. [PDF]
PLoS ONE, 2018 Glucosamine (GlcN) is a naturally occurring derivative of glucose and an over-the-counter food additive. However, the mechanism underlying GlcN action on cells is unknown. In this study, we investigated the effect of GlcN on natural killer (NK) cells. We
Janja Božič +2 more
doaj +1 more source
Generation of human endothelin by cathepsin E [PDF]
FEBS Letters, 1990 Highly‐purified cathepsin D processed human big endothelin1–38 into endothelin‐like fragments but did not appear to generate endothelin1–21 under the conditions employed. By contrast, human cathepsin E specifically cleaved human big endothelin into endothelin1–21 and the C‐terminal fragment under identical conditions but did not degrade either product ...
Lees, Wendy E. +5 more
openaire +2 more sources
Inhibition of cathepsin B by E-64 induces oxidative stress and apoptosis in filarial parasite. [PDF]
PLoS ONE, 2014 Current available antifilarial drug strategies only eliminate the larval stages of filarial parasites. Therefore, there is an urgent need of drugs which are macrofilaricidals.
Mohit Wadhawan +2 more
doaj +1 more source
Cathepsin B Mediates the pH-Dependent Proinvasive Activity of Tumor-Shed Microvesicles
Neoplasia: An International Journal for Oncology Research, 2008 Vesicles shed by cancer cells are known to mediate several tumor-host interactions. Tumor microenvironment may, in turn, influence the release and the activity of tumor-shed microvesicles.
Ilaria Giusti +7 more
doaj +1 more source
Microbiology Spectrum, 2023 Ebola virus (EBOV) causes a hemorrhagic fever with fatality rates up to 90%. The EBOV entry process is complex and incompletely understood. Following attachment to host cells, EBOV is trafficked to late endosomes/lysosomes where its glycoprotein (GP) is ...
Laura Odongo +4 more
doaj +1 more source
A structural biology approach to understand human lymphatic filarial infection. [PDF]
PLoS Neglected Tropical Diseases, 2014 The presence of aspartic protease inhibitor in filarial parasite Brugia malayi (Bm-Aspin) makes it interesting to study because of the fact that the filarial parasite never encounters the host digestive system.
Raghavendra Sashi Krishna Nagampalli +4 more
doaj +1 more source
Cathepsin E (EC 3.4.23.34) — a review
Folia Histochemica et Cytobiologica, 2012 Cathepsin E belongs to the third class of enzymes - hydrolases, a subclass of peptide bond hydrolases and a sub-subclass of endopeptidases with aspartic catalytic sites. Cathepsin E is an endopeptidase with substrate specificity similar to that of cathepsin D. In a human organism, cathepsin E occurs in: erythrocytes, thymus, dendritic cells, epithelial
Michał, Chlabicz +3 more
openaire +3 more sources
Altered gene expression in early atherosclerosis is blocked by low level apolipoprotein E.
PLoS ONE, 2008 BackgroundMice deficient in apolipoprotein E (apoE(-/-)) develop atherosclerosis. The possible linkage between expression of adhesion molecules/cofactors and atherosclerosis was probed at the level of mRNA and protein expression.
Yanqing Ma +3 more
doaj +1 more source
PLoS ONE, 2011 Merozoite Surface Protein 1 is expressed on the surface of malaria merozoites and is important for invasion of the malaria parasite into erythrocytes. MSP1-specific CD4 T cell responses and antibody can confer protective immunity in experimental models ...
Calogero Tulone +5 more
doaj +1 more source