Results 71 to 80 of about 60,305 (241)

Deciphering the role of cathepsins in digestive system cancers: a Mendelian randomization study

Discover Oncology
Digestive system cancers (DSCs) present a global health challenge. This study aimed to investigate the causal relationships between cathepsins and DSCs using Mendelian Randomization (MR) analysis.
Beian Guo, Zhiyi Zhou, Wanzhe Liao, Yurong Zheng, Yinjie Liao, Ruiqi Zeng   +5 more
doaj   +1 more source

The Endosomal Trafficking of Apolipoprotein E3 and E4 in Cultured Human Brain Neurons and Astrocytes

Neurobiology of Disease, 2001
The association of the E4 isoform of apolipoprotein E (apoE) as a genetic risk factor for late onset Alzheimer's disease (AD) has been well established.
Robert M. DeKroon, Patricia J. Armati
doaj   +1 more source

Disulfide‐Bridged Ru Complex–Mediated Photo‐Disulfidptosis for Colorectal Cancer Therapy

Advanced Science, EarlyView.
In this work, a binuclear ruthenium complex, RuSSRu was developed for efficient colorectal cancer (CRC) treatment. The synergistic interaction between disulfidptosis and lysosomal damage‐induced apoptosis induced by RuSSRu amplified tumor cell death. This innovative approach offers a potent therapeutic strategy for CRC.
Simeng He, Wendong Jin, Jiaojiao Pang, Xiaoting Gong, Shixian Cao, Duo Mao, Yuguo Chen, Kang‐Nan Wang, Bin Liu   +8 more
wiley   +1 more source

3D Bioprinted Fat‐Myocardium Model Unravels the Role of Adipocyte Hypertrophy in Atrial Dysfunction

Advanced Science, EarlyView.
A human‐derived 3D bioprinted fat–myocardium model is developed to investigate how adipocyte hypertrophy drives atrial dysfunction in obesity. Palmitate‐induced adipocyte hypertrophy promotes adipose dysfunction that impairs atrial cardiomyocyte metabolism and electrophysiology through both paracrine and direct interactions. This platform recapitulates
Lara Ece Celebi, Pinar Zorlutuna
wiley   +1 more source

Cathepsin S As an Inhibitor of Cardiovascular Inflammation and Calcification in Chronic Kidney Disease

Frontiers in Cardiovascular Medicine, 2018
Cardiovascular disease (CVD) is responsible for the majority of deaths in the developed world. Particularly, in patients with chronic kidney disease (CKD), the imbalance of calcium and phosphate may lead to the acceleration of both vascular and valve ...
Brena F. Sena, Jose Luiz Figueiredo, Elena Aikawa   +2 more
doaj   +1 more source

Microglial cathepsin E plays a role in neuroinflammation and amyloid β production in Alzheimer's disease. [PDF]

Aging Cell, 2022
Xie Z, Meng J, Kong W, Wu Z, Lan F, Narengaowa, Hayashi Y, Yang Q, Bai Z, Nakanishi H, Qing H, Ni J.   +11 more
europepmc   +1 more source

Ligand‐Induced Electronic Response Enables Predictive QM/MM Simulations

Advanced Science, EarlyView.
Quantum mechanics/molecular mechanics (QM/MM) simulations are powerful tools for modeling complex molecular systems; however, their predictability has been constrained by the ambiguous definition of the QM region. An electronically informed protocol is introduced that defines QM regions by quantifying guest‐induced orbital shifts and charge ...
Nichika Ozawa, Nahoko Kuroki, Hirotoshi Mori   +2 more
wiley   +1 more source

The causal relationship between cathepsins and digestive system tumors: a Mendelian randomization study

Frontiers in Oncology
BackgroundMultiple studies have confirmed the significant role of cathepsins in the development and progression of digestive system tumors. However, further investigation is needed to determine the causal relationships.MethodsWe conducted a two-sample ...
Xupeng Huang, Houbo Deng, Bo Zhang, Kuisong Wang, Yi Qu, Ting Li, Tiejun Liu   +6 more
doaj   +1 more source

Identification of a Force‐Induced Sox9+Acan+ Transitional Subpopulation Linked to FGF2–FGFR2–ERK Signaling in Orthodontic Bone Remodeling

Advanced Science, EarlyView.
Mechanical loading induces a previously unrecognized Sox9+Acan+ transitional mesenchymal cell population in the periodontal ligament that promotes osteoclastogenesis via the FGF2–FGFR2–ERK axis. Targeting this mechanoresponsive stromal population using a localized GelMA@siRNA delivery strategy attenuates pathological osteoclast overactivation and root ...
Miao Tan, Minyu He, Mingrui Zong, Qiya Tang, Yinan Liu, Jiaju Deng, Shun Huang, Xiaoxiao Lei, Jie Li, Lan Huang   +9 more
wiley   +1 more source

Molecular characterization of a cathepsin F-like protease in Trichinella spiralis

Parasites & Vectors, 2015
Background Trichinellosis is a re-emerging infectious disease, caused by Trichinella spp. Cathepsin F belongs to cysteine protease that is a major virulence factor for parasitic helminths, and it may be a potential anti-helminth drug target and vaccine ...
Zi-gang Qu, Xue-ting Ma, Wen-hui Li, Nian-zhang Zhang, Long Yue, Jian-min Cui, Jian-ping Cai, Wan-zhong Jia, Bao-quan Fu   +8 more
doaj   +1 more source