Results 101 to 110 of about 16,299,323 (310)

Endosomal acidification and cathepsin L activity is required for calicivirus replication

Virology, 2014
The role of cellular proteases and endosome maturation in the entry of caliciviruses including porcine enteric calicivirus (PEC), murine norovirus (MNV)-1 and feline calicivirus (FCV) were investigated.
Vinay Shivanna, Yunjeong Kim, Kyeong-Ok Chang   +2 more
semanticscholar   +1 more source

Macrophage Extracellular Traps in Immunity and Cancer

Advanced Science, EarlyView.
As a macrophage‐mediated innate defense mechanism, the dysregulated release of METs drives chronic inflammation and influences tumor progression. Furthermore, METs exhibit a functional duality within the tumor microenvironment, capable of both promoting and suppressing tumor development.
Junyao Li, Eugenie Nepovimova, Adam Grundel, Lukas Peter, Qinghua Wu, Kamil Kuca   +5 more
wiley   +1 more source

Plasma cathepsin L: a prognostic marker for pancreatic cancer.

World Journal of Gastroenterology, 2014
AIM To assess the prognostic significance of cathepsin L, a cysteine protease that degrades the peri-tumoral tissue, in patients with pancreatic cancer. METHODS Plasma samples from 127 pancreatic cancer patients were analyzed for cathepsin L levels by ...
Nidhi Singh, P. Das, Surabhi Gupta, Vikas Sachdev, S. Srivasatava, S. Datta Gupta, R. Pandey, P. Sahni, S. Chauhan, A. Saraya   +9 more
semanticscholar   +1 more source

A Cascade Recognition of Activatable Probe for Fluorescence Navigation Glioblastoma Surgery: Overcoming Blood‐Brain Barrier and Off‐Target Limitations

Advanced Science, EarlyView.
A cascade recognition of activatable probe ANG‐hCy‐MC is used for high‐precision depiction of glioblastoma (GBM) margin. This probe crosses the blood‐brain barrier (BBB) through LRP1 receptor‐mediated transport and provides excellent fluorescence signal contrast between the tumor and normal tissues, thereby enabling ultra‐selective imaging and precise ...
Xinru An, Yu Guo, Yongning Bian, Yanli Tan, Chuan Fang, Hengzhu Zhang, Xueqian Chen, Lin Yuan, Dongdong Su   +8 more
wiley   +1 more source

The Role of Cathepsin B in Peritoneal Fibrosis due to Peritoneal Dialysis

International Journal of Nephrology, 2019
Glucose-containing peritoneal dialysis (PD) solution causes peritoneal fibrosis (PF) characterized by accumulation of extracellular matrix (ECM) in the submesothelial layer.
Su Ah Sung, Dong Hee Kim, Kook-Hwan Oh, Sang Youb Han, Kum Hyun Han   +4 more
doaj   +1 more source

Molecular cloning and characterization of cathepsin L from freshwater mussel, Cristaria plicata.

Fish and Shellfish Immunology, 2014
Cathepsin L is one of the crucial enzyme superfamilies and involved in the immune responses. The Cathepsin L cDNA and genome of Cristaria plicata（CpCL） was cloned from the hemocytes using degenerate primers by the rapid amplification of cDNA ends (RACE ...
Xiaojuan Hu, Xiang-ping Hu, Baoqing Hu, C. Wen, Yanhai Xie, Dan Wu, Zhiying Tao, Aihua Li, Q. Gao   +8 more
semanticscholar   +1 more source

ZMAT1 Promotes Osteoclastogenesis Through TRIM46 Mediated YAP1 Degradation and Inhibits Osteoblastogenesis

Advanced Science, EarlyView.
Zmat1 deficiency mitigates pathological bone loss by impairing osteoclastogenesis and promoting osteoblastogenesis. Mechanistically, in osteoclasts, Zmat1 loss relieves transcriptional repression of the E3 ligase TRIM46, promoting YAP1 degradation and inhibiting osteoclastogenic genes.
Xinyu Chang, Yijin Hou, Likun Cui, Huiqi Yu, Rong Liu, Junhao Sui, Zhong Zheng, Lu Liu, Jie Chen, Mengchen Chen, Chen Ding, Shuogui Xu, Sheng Xu, Hao Zhang   +13 more
wiley   +1 more source

A Mitochondria‐Specific Nanomedicine for Synergistic Chemo‐Photothermal Therapy and Immunogenic Activation Against Breast Cancer

Advanced Science, EarlyView.
Peptide dendrimer–based nanoplatform with mitochondria‐targeting capability was developed for synergistic chemo‐photothermal therapy. The system promotes efficient transcytosis, induces mitochondrial dysfunction, triggers immunogenic cell death (ICD), and enhance antitumor immunity by promoting dendritic cell maturation and T‐cell activation, resulting
Min Li, Jiangqi Feng, Junyang Zhuang, Qingguo Zhong, Yanda Li, Yanzhuo Lv, Shaoteng Huang, Xiangyu Huang, Mingbo Zhang, Xiaofeng Cai, Yuxin Wang, Wenping Chen, Zhenyu Duan, Zhou Chen, Kui Luo, Ning Li   +15 more
wiley   +1 more source

Peripheral cathepsin L inhibition induces fat loss in C. elegans and mice through promoting central serotonin synthesis

BMC Biology, 2019
Background Cathepsin L and some other cathepsins have been implicated in the development of obesity in humans and mice. The functional inactivation of the proteases reduces fat accumulation during mammalian adipocyte differentiation.
Yan Lin, Bin Bao, Hao Yin, Xin Wang, Airong Feng, Lin Zhao, Xianqi Nie, Nan Yang, Guo-Ping Shi, Jian Liu   +9 more
doaj   +1 more source

BRCA1 loss activates cathepsin L–mediated degradation of 53BP1 in breast cancer cells

Journal of Cell Biology, 2013
Cathepsin L degrades 53BP1 to overcome genomic instability and growth arrest in BRCA1-deficient and triple-negative breast cancers.
David A Grotsky, I. Gonzalez-Suarez, A. Novell, Martin A. Neumann, Sree C. S. Yaddanapudi, M. Croke, M. Martinez-Alonso, Abena B. Redwood, S. Ortega-Martínez, Zhihui Feng, E. Lerma, T. Ramón Y Cajal, Junran Zhang, X. Matías-Guiu, A. Dusso, S. Gonzalo   +15 more
semanticscholar   +1 more source