Results 151 to 160 of about 16,299,323 (310)

Identification of Cathepsin L as the Molecular Target of Hydroxychloroquine With Chemical Proteomics. [PDF]

Mol Cell Proteomics
Shang J, Hu B, Kung KK, Jiang J, Zhang Q, Wong MK, Chu H, Zhao Q.   +7 more
europepmc   +1 more source

Cathepsin L is crucial for the development of early experimental diabetic nephropathy.

Kidney International, 2016
M. Garsen, A. Rops, H. Dijkman, Brigith K. Willemsen, T. V. van Kuppevelt, F. Russel, T. Rabelink, J. Berden, T. Reinheckel, J. van der Vlag   +9 more
semanticscholar   +1 more source

TcALS knockdown accelerates metamorphosis via insulin signaling in Tribolium castaneum

Insect Science, EarlyView.
RNAi silencing of TcALS accelerates larva‐to‐pupa metamorphosis in Tribolium castaneum. Abstract Insect metamorphosis is an evolutionary adaptation precisely regulated by nutritional and hormonal cues. The red flour beetle Tribolium castaneum, a major stored‐product pest, serves as an excellent model for studying this process.
Min Li, Jie Chen, Zi‐Ye Wang, Fei‐Feng Wang, Lu‐Lu Dong, Jun Pan, Min‐Er Li, Lin Yu, Wen Sang   +8 more
wiley   +1 more source

Human keratinocytes exhibit limited potential for SARS-CoV-2 infection despite ACE2 and mature cathepsin L expression. [PDF]

JID Innov
Hertereau L, Barthe M, Lamghari N, Merida P, Pommier G, Pinel E, Swain J, Muriaux D, Osman-Ponchet H, Braud VM.   +9 more
europepmc   +1 more source

Correction: Eosinophils promote pulmonary matrix destruction and emphysema via Cathepsin L. [PDF]

Signal Transduct Target Ther, 2023
Xu X, Yu T, Dong L, Glauben R, Wu S, Huang R, Qumu S, Chang C, Guo J, Pan L, Yang T, Lin X, Huang K, Chen Z, Wang C.   +14 more
europepmc   +1 more source

Novel drugs approved by the EMA, the FDA and the MHRA in 2025: A year in review

British Journal of Pharmacology, EarlyView.
Abstract In the 2025 novel drug mini‐review, one can take a full measure of the ingenuity that underlies current drug design and development, despite the year's smaller harvest (46 novel drugs) compared to 2024 (53) and 2023 (70). 54% of the novel drugs are first‐in‐class (FIC).
Andreas Papapetropoulos, Stavros Topouzis, Steve P. H. Alexander, Miriam M. Cortese‐Krott, Zsuzsanna Helyes, Kirill Martemyanov, Claudio Mauro, Nithyanandan Nagercoil, Reynold A. Panettieri Jr, Hemal H. Patel, Rainer Schulz, Barbara Stefanska, Gary J. Stephens, Nathalie Vergnolle, Xin Wang, Stephen Ward, Péter Ferdinandy   +16 more
wiley   +1 more source

Cannabidiol and cannabigerol ameliorate steatotic liver disease via phosphocreatine buffering and lysosomal restoration

British Journal of Pharmacology, EarlyView.
Cannabidiol (CBD) and cannabigerol (CBG) alleviate hepatic steatosis in obese mice by shifting energy buffering towards phosphocreatine and enhancing lysosomal lipid degradation and trafficking. These effects are associated with increased creatine kinase activity and lysobisphosphatidic acid (LBPA) levels, highlighting a previously unrecognised ...
Radka Kočvarová, Shahar Azar, Bella Agranovich, Ifat Abramovich, Saveliy Kirillov, Alina Nemirovski, Saja Baraghithy, Inbar Plaschkes, Emmanuelle Merquiol, Alexander Rouvinski, Galia Blum, Liad Hinden, Joseph Tam   +12 more
wiley   +1 more source

Single-dose cathepsin L CRISPR nanotherapy mitigates PASC-like lung damage in hamsters. [PDF]

Nano Res
Cui Z, Liu T, Bacon R, Zhao Y, Everitt JI, Yan J, Chen L, Huang J, Wang H, Dong Y, Jin VX, Liu SL, Wang Q.   +12 more
europepmc   +1 more source

The Diagnostic Odyssey of a Biochemically Confirmed Case of ML II: The First Western Patient With LYSET Deficiency

Clinical Genetics, EarlyView.
We identify a female patient with a homozygous nonsense variant (p.Gln38Ter) in the LYSET gene. This is the first western report of a challenging case of an extensive diagnostic odyssey and demonstrates that the LYSET gene must be considered in the differential diagnosis when M6P‐labeled lysosomal enzymes are altered.
Fernanda Sperb‐Ludwig, Taciane Alegra, Leonardo Martinello da Rosa, Nataniel Floriano Ludwig, Renata Voltolini Velho, Ida Vanessa Doederlein Schwartz   +5 more
wiley   +1 more source

The functional of cathepsin L in the ontogenesis and reproductive regulation of the Asian corn borer, Ostrinia furnacalis. [PDF]

Sci Rep
Zhang JS, Li J, Meng JY, Tang X, Saddique H, Zhang CY.   +5 more
europepmc   +1 more source