Results 11 to 20 of about 16,299,323 (310)

Effect of Lysosomal Cathepsin L on Proteolysis of Beef Myofibrillar Proteins In Vivo and In Vitro

Foods, 2022
This study investigated the effects of cathepsin L on proteolysis of beef myofibrillar proteins in vivo and in vitro. Results indicated that cathepsin L affected the degradation of desmin and troponin-T during postmortem aging, and the extent of ...
Baowei Cui, Xiuyun Guo, Yawei Zhang, Xiangren Meng   +3 more
doaj   +1 more source

Potent Anti-SARS-CoV-2 Activity by the Natural Product Gallinamide A and Analogues via Inhibition of Cathepsin L

Journal of Medicinal Chemistry, 2021
Cathepsin L is a key host cysteine protease utilized by coronaviruses for cell entry and is a promising drug target for novel antivirals against SARS-CoV-2.
Anneliese S. Ashhurst, A. H. Tang, Pavla Fajtová, Michael C Yoon, A. Aggarwal, Max J Bedding, Alexander Stoye, L. Beretta, D. Pwee, A. Drelich, Danielle Skinner, Linfeng Li, T. Meek, J. McKerrow, V. Hook, C. Tseng, M. Larance, S. Turville, W. Gerwick, A. O’Donoghue, R. Payne   +20 more
semanticscholar   +1 more source

Characterization of Cysteine Cathepsin Expression in the Central Nervous System of Aged Wild-Type and Cathepsin-Deficient Mice

Applied Sciences, 2022
The association of cathepsin proteases in neurobiology is increasingly recognized. Our previous studies indicated that cathepsin-K-deficient (Ctsk−/−) mice have learning and memory impairments.
Denise M. T. Yu, Stephanie Dauth, Michael B. Margineanu, Valentina Snetkova, Maren Rehders, Silvia Jordans, Klaudia Brix   +6 more
doaj   +1 more source

Regulatory role of cathepsin L in induction of nuclear laminopathy in Alzheimer’s disease

Aging Cell, 2021
Experimental and clinical therapies in the field of Alzheimer's disease (AD) have focused on elimination of extracellular amyloid beta aggregates or prevention of cytoplasmic neuronal fibrillary tangles formation, yet these approaches have been generally
Md Imamul Islam, P. Nagakannan, Tetiana Shcholok, Fabio Contu, S. Mai, B. Albensi, M. D. Del Bigio, Jun-Feng Wang, Md Golam Sharoar, R. Yan, I. Park, E. Eftekharpour   +11 more
semanticscholar   +1 more source

Human liver cathepsin L [PDF]

Biochemical Journal, 1985
Cathepsin L was purified to apparent homogeneity from human liver obtained post mortem. It was necessary to treat the homogenate at pH 4.2 and 37 degrees C to release active enzyme. The purification procedure involved ion-exchange chromatography on carboxymethyl-Sephadex and the Mono S column of a Pharmacia fast-protein-liquid-chromatography system ...
R W, Mason, G D, Green, A J, Barrett
openaire   +2 more sources

Cathepsin L plays a key role in SARS-CoV-2 infection in humans and humanized mice and is a promising target for new drug development

Signal Transduction and Targeted Therapy, 2020
To discover new drugs to combat COVID-19, an understanding of the molecular basis of SARS-CoV-2 infection is urgently needed. Here, for the first time, we report the crucial role of cathepsin L (CTSL) in patients with COVID-19.
Miao-Miao Zhao, Weili Yang, Fang-Yuan Yang, Li Zhang, Weijing Huang, W. Hou, Changfa Fan, R. Jin, Yingmei Feng, Youchun Wang, Jin-Kui Yang   +10 more
semanticscholar   +1 more source

Structure and inhibition of the SARS-CoV-2 main protease reveal strategy for developing dual inhibitors against Mpro and cathepsin L

Science Advances, 2020
X-ray crystal structures of SARS-CoV-2 Mpro with dual inhibitors provide a new direction for the designing of COVID-19 antivirals. The main protease (Mpro) of SARS-CoV-2 is a key antiviral drug target. While most Mpro inhibitors have a γ-lactam glutamine
M. Sacco, Chunlong Ma, Panagiotis Lagarias, A. Gao, J. A. Townsend, Xiangzhi Meng, P. Dube, Xiujun Zhang, Yanmei Hu, Naoya Kitamura, B. Hurst, Bart Tarbet, M. Marty, A. Kolocouris, Y. Xiang, Yu Chen, Jun Wang   +16 more
semanticscholar   +1 more source

Cathepsin L-selective inhibitors: A potentially promising treatment for COVID-19 patients

Pharmacology and Therapeutics, 2020
The widespread coronavirus SARS-CoV-2 has already infected over 4 million people worldwide, with a death toll over 280,000. Current treatment of COVID-19 patients relies mainly on antiviral drugs lopinavir/ritonavir, arbidol, and remdesivir, the anti ...
Tianxiao Liu, Songyuan Luo, P. Libby, G. Shi   +3 more
semanticscholar   +1 more source

Cathepsin L inhibition prevents murine autoimmune diabetes via suppression of CD8(+) T cell activity. [PDF]

PLoS ONE, 2010
BACKGROUND: Type 1 diabetes (T1D) is an autoimmune disease resulting from defects in central and peripheral tolerance and characterized by T cell-mediated destruction of islet β cells. To determine whether specific lysosomal proteases might influence the
Akiko Yamada, Naozumi Ishimaru, Rieko Arakaki, Nobuhiko Katunuma, Yoshio Hayashi   +4 more
doaj   +1 more source

Cathepsin L in COVID-19: From Pharmacological Evidences to Genetics

Frontiers in Cellular and Infection Microbiology, 2020
The coronavirus disease 2019 (COVID-19) pandemics is a challenge without precedent for the modern science. Acute Respiratory Discomfort Syndrome (ARDS) is the most common immunopathological event in SARS-CoV-2, SARS-CoV, and MERS-CoV infections.
C. P. Gomes, D. E. Fernandes, F. Casimiro, G. F. da Mata, M. T. Passos, Patrícia Varela, G. Mastroianni-Kirsztajn, J. Pesquero   +7 more
semanticscholar   +1 more source