Results 11 to 20 of about 29,235,414 (292)

Cathepsin L increases invasion and migration of B16 melanoma [PDF]

Cancer Cell International, 2007
Background Most cancers express elevated protease levels which contribute to certain aspects of tumor behavior such as growth, metastatic spread, and angiogenesis.
Cox James L, Yang Zhen
doaj   +2 more sources

Extracellular cathepsin L stimulates axonal growth in neurons

BMC Research Notes, 2017
Objective Cathepsin L, a lysosomal endopeptidase expressed in most eukaryotic cells, is a member of the papain-like family of cysteine proteases. Although commonly recognized as a lysosomal protease, cathepsin L is also secreted and involved in the ...
Chihiro Tohda, Michihisa Tohda
doaj   +2 more sources

Molecular cloning and characterization of cathepsin L from freshwater mussel, Cristaria plicata.

Fish and Shellfish Immunology, 2014
Cathepsin L is one of the crucial enzyme superfamilies and involved in the immune responses. The Cathepsin L cDNA and genome of Cristaria plicata（CpCL） was cloned from the hemocytes using degenerate primers by the rapid amplification of cDNA ends (RACE ...
Xiaojuan Hu, Xiang-Ping Hu, Bao-Qing Hu, Chun-Gen Wen, Yan-Hai Xie, Dan Wu, Zhi-Ying Tao, Ai-Hua Li, Q. Gao   +8 more
semanticscholar   +2 more sources

Potent Anti-SARS-CoV-2 Activity by the Natural Product Gallinamide A and Analogues via Inhibition of Cathepsin L

Journal of Medicinal Chemistry, 2021
Cathepsin L is a key host cysteine protease utilized by coronaviruses for cell entry and is a promising drug target for novel antivirals against SARS-CoV-2.
Anneliese S. Ashhurst, A. H. Tang, Pavla Fajtová, Michael C. Yoon, A. Aggarwal, Max J. Bedding, Alexander Stoye, L. Beretta, D. Pwee, A. Drelich, Danielle Skinner, Linfeng Li, T. D. Meek, J. McKerrow, V. Hook, C. Tseng, Mark Larance, S. Turville, W. Gerwick, A. O'Donoghue, Richard J. Payne   +20 more
semanticscholar   +1 more source

Characterization of Cysteine Cathepsin Expression in the Central Nervous System of Aged Wild-Type and Cathepsin-Deficient Mice

Applied Sciences, 2022
The association of cathepsin proteases in neurobiology is increasingly recognized. Our previous studies indicated that cathepsin-K-deficient (Ctsk−/−) mice have learning and memory impairments.
Denise M. T. Yu, Stephanie Dauth, Michael B. Margineanu, Valentina Snetkova, Maren Rehders, Silvia Jordans, Klaudia Brix   +6 more
doaj   +1 more source

Regulatory role of cathepsin L in induction of nuclear laminopathy in Alzheimer’s disease

Aging Cell, 2021
Experimental and clinical therapies in the field of Alzheimer's disease (AD) have focused on elimination of extracellular amyloid beta aggregates or prevention of cytoplasmic neuronal fibrillary tangles formation, yet these approaches have been generally
Md Imamul Islam, P. Nagakannan, Tetiana Shcholok, Fabio Contu, S. Mai, B. Albensi, M. D. Del Bigio, Junfeng Wang, Md. Golam Sharoar, R. Yan, Il-Seon Park, E. Eftekharpour   +11 more
semanticscholar   +1 more source

Heparin modulates the endopeptidase activity of Leishmania mexicana cysteine protease cathepsin L-Like rCPB2.8 [PDF]

, 2013
Cysteine protease B is considered crucial for the survival and infectivity of the Leishmania in its human host. Several microorganism pathogens bind to the heparin-like glycosaminoglycans chains of proteoglycans at host-cell surface to promote their ...
Gesteira, Tarsis F., Tarsis F Gesteira, Gesteira Tarsis F., Sanya J Sanderson, Tersariol, Ivarne L.S., Westrop, Gareth, Sansevero, Thiago M., Shida, Claudio S. [UNIFESP], Manfredi, Marcella A, Tersariol, Ivarne Luis dos Santos [UNIFESP], Gerson P Souza, Ivarne L S Tersariol, Luiz Juliano, Manfredi Marcella A., Gareth D Westrop, Sansevero Thiago M., Almeida Paulo C., Tersariol Ivarne L. S., Souza, Gerson A., Manfredi, Marcella A., Sanderson Sanya J., Thiago M Sansevero, Souza, Gerson P., Juliano, Luiz, Westrop, Gareth D., Almeida, Paulo C. [UNIFESP], Judice, W.A.S., Paulo C Almeida, Judice Wagner A. S., Coombs Graham H., Coombs, Graham H., Shida, Claudio S., Shida Cláudio S., Cláudio S Shida, Souza Gerson P., Almeida, Paulo C, Judice, Wagner A. S., Marcella A Manfredi, Sanderson, Sanya J, Coombs, Graham, Juliano, Luiz [UNIFESP], Wagner A S Judice, Juliano Luiz, Sanderson, Sanya J., Graham H Coombs, Westrop Gareth D.   +45 more
core   +4 more sources

Cathepsin L plays a key role in SARS-CoV-2 infection in humans and humanized mice and is a promising target for new drug development

Signal Transduction and Targeted Therapy, 2020
To discover new drugs to combat COVID-19, an understanding of the molecular basis of SARS-CoV-2 infection is urgently needed. Here, for the first time, we report the crucial role of cathepsin L (CTSL) in patients with COVID-19.
Miao-Miao Zhao, Weili Yang, Fang-Yuan Yang, Li Zhang, Wei-Jing Huang, Wei Hou, Changfa Fan, R. Jin, Yingmei Feng, You-Chun Wang, Jinkui Yang   +10 more
semanticscholar   +1 more source

Structure and inhibition of the SARS-CoV-2 main protease reveal strategy for developing dual inhibitors against Mpro and cathepsin L

Science Advances, 2020
X-ray crystal structures of SARS-CoV-2 Mpro with dual inhibitors provide a new direction for the designing of COVID-19 antivirals. The main protease (Mpro) of SARS-CoV-2 is a key antiviral drug target. While most Mpro inhibitors have a γ-lactam glutamine
M. Sacco, Chunlong Ma, Panagiotis Lagarias, A. Gao, J. A. Townsend, Xiangzhi Meng, P. Dube, Xiu-Jun Zhang, Yanmei Hu, Naoya Kitamura, Brett L. Hurst, B. Tarbet, M. Marty, A. Kolocouris, Yan Xiang, Yu Chen, Jun Wang   +16 more
semanticscholar   +1 more source

Cathepsin L-selective inhibitors: A potentially promising treatment for COVID-19 patients

Pharmacology and Therapeutics, 2020
The widespread coronavirus SARS-CoV-2 has already infected over 4 million people worldwide, with a death toll over 280,000. Current treatment of COVID-19 patients relies mainly on antiviral drugs lopinavir/ritonavir, arbidol, and remdesivir, the anti ...
Tianxiao Liu, Songyuan Luo, P. Libby, G. Shi   +3 more
semanticscholar   +1 more source