Results 231 to 240 of about 29,235,414 (292)

Structural Elucidation and Antiviral Activity of Covalent Cathepsin L Inhibitors. [PDF]

J Med Chem
Falke S, Lieske J, Herrmann A, Loboda J, Karničar K, Günther S, Reinke PYA, Ewert W, Usenik A, Lindič N, Sekirnik A, Dretnik K, Tsuge H, Turk V, Chapman HN, Hinrichs W, Ebert G, Turk D, Meents A.   +18 more
europepmc   +1 more source

Out-of-frame start codons prevent translation of truncated nucleo-cytosolic cathepsin L in vivo

Nature Communications, 2014
Martina Tholen, L. E. Hillebrand, Stefan Tholen, Oliver Sedelmeier, S. Arnold, T. Reinheckel   +5 more
semanticscholar   +1 more source

Periodontitis and rheumatoid arthritis—Global efforts to untangle two complex diseases

Periodontology 2000, EarlyView.
Abstract Understanding the impact of oral health on rheumatoid arthritis (RA) will inform how best to manage patients with both periodontitis and RA. This review seeks to provide an update on interventional and mechanistic investigations, including a brief summary of European Research programs investigating the link between periodontitis and RA. Recent
Isabel Lopez‐Oliva, Jennifer Malcolm, Shauna Culshaw   +2 more
wiley   +1 more source

Inflammation and mechanical force‐induced bone remodeling

Periodontology 2000, EarlyView.
Abstract Periodontitis arises from imbalanced host–microbe interactions, leading to dysbiosis and destructive inflammation. The host's innate and adaptive immune responses produce pro‐inflammatory mediators that stimulate destructive events, which cause loss of alveolar bone and connective tissue attachment.
Hyeran Helen Jeon, Xin Huang, Leticia Rojas Cortez, Puttipong Sripinun, Jung‐me Lee, Julie J. Hong, Dana T. Graves   +6 more
wiley   +1 more source

Elevated N-glycosylated cathepsin L impairs oocyte function and contributes to oocyte senescence during reproductive aging. [PDF]

Aging Cell
Zhang K, Xu R, Zheng L, Zhang H, Qian Z, Li C, Xue M, He Z, Ma J, Li Z, Chen L, Ma R, Yao B.   +12 more
europepmc   +1 more source

Genetic risk variants implicate impaired maintenance and repair of periodontal tissues as causal for periodontitis—A synthesis of recent findings

Periodontology 2000, EarlyView.
AbstractPeriodontitis is a complex inflammatory disease in which the host genome, in conjunction with extrinsic factors, determines susceptibility and progression. Genetic predisposition is the strongest risk factor in the first decades of life. As people age, chronic exposure to the periodontal microbiome puts a strain on the proper maintenance of ...
Arne S. Schaefer, Luigi Nibali, Noha Zoheir, Niki M. Moutsopoulos, Bruno G. Loos   +4 more
wiley   +1 more source

Cathepsin L induces cellular senescence by upregulating CUX1 and p16^INK4a. [PDF]

Aging (Albany NY)
Wu Y, Jiang D, Liu Q, Yan S, Liu X, Wu T, Sun W, Li G.   +7 more
europepmc   +1 more source

Structural elucidation and antiviral activity of cathepsin L inhibitors with carbonyl and epoxide warheads

, 2023
Falke S, Lieske J, Herrmann A, Loboda J, Günther S, Reinke PY, Ewert W, Karničar K, Usenik A, Lindič N, Sekirnik A, Tsuge H, Turk V, Chapman HN, Hinrichs W, Ebert G, Turk D, Meents A.   +17 more
europepmc   +1 more source

Biological definition of periodontal diseases: A historical review of host‐response diagnostics and their implications for disease classification

Periodontology 2000, EarlyView.
Abstract Background Understanding periodontal diseases through a biological lens has been a central aim in periodontal research. Visionary pioneers in the field established the foundations of our knowledge, providing invaluable insights into disease mechanisms and progression.
Nagihan Bostanci, Melissa M. Grant, Moritz Kebschull   +2 more
wiley   +1 more source

Hyperglycemia induced cathepsin L maturation linked to diabetic comorbidities and COVID-19 mortality. [PDF]

Elife
He Q, Zhao MM, Li MJ, Li XY, Jin JM, Feng YM, Zhang L, Huang WJ, Yang F, Yang JK.   +9 more
europepmc   +1 more source