Results 31 to 40 of about 16,299,323 (310)
Respiratory Research, 2011 Background Remodeling of lung tissues during the process of granuloma formation requires significant restructuring of the extra-cellular matrix and cathepsins K, L and S are among the strongest extra-cellular matrix degrading enzymes.
Percival M David +3 more
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Cathepsin B gene disruption induced Leishmania donovani proteome remodeling implies cathepsin B role in secretome regulation. [PDF]
PLoS ONE, 2013 Leishmania cysteine proteases are potential vaccine candidates and drug targets. To study the role of cathepsin B cysteine protease, we have generated and characterized cathepsin B null mutant L. donovani parasites. L.
Teklu Kuru Gerbaba, Lashitew Gedamu
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Human cathepsin L rescues the neurodegeneration and lethality in cathepsin B/L double-deficient mice [PDF]
Biological Chemistry, 2006 Abstract Cathepsin B (CTSB) and cathepsin L (CTSL) are two widely expressed cysteine proteases thought to predominantly reside within lysosomes. Functional analysis of CTSL in humans is complicated by the existence of two CTSL-like homologs (CTSL and CTSL2), in contrast to mice, which possess only one CTSL enzyme.
Sevenich, Lisa +3 more
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Collagenolytic cysteine proteinases of bone tissue. Cathepsin B, (pro)cathepsin L and a cathepsin L-like 70 kDa proteinase [PDF]
Biochemical Journal, 1991 The aim of the work was to identify and characterize the cysteine proteinases of bone tissue, as these enzymes appear necessary for bone resorption. Three cysteine-dependent proteolytic activities were separated from a homogenate of mouse calvaria by a fractionation procedure involving (NH4)2SO4 precipitation, gel filtration and ion-exchange ...
J M, Delaissé, P, Ledent, G, Vaes
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Indian Journal of Pathology and Microbiology, 2015 Background: Cysteine protease Cathepsin L is involved in bone remodeling and expressed in activated macrophages. It is highly expressed in metastatic tumor tissue, especially with bone metastases.
Bivas Biswas +3 more
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Cathepsin L plays a role in quinolinic acid-induced NF-Κb activation and excitotoxicity in rat striatal neurons. [PDF]
PLoS ONE, 2013 The present study seeks to investigate the role of cathepsin L in glutamate receptor-induced transcription factor nuclear factor-kappa B (NF-κB) activation and excitotoxicity in rats striatal neurons.
Yan-Ru Wang +6 more
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A humanized antibody inhibitor for cathepsin L [PDF]
Protein Science, 2020 AbstractCathepsin L (CTSL) is a cysteine protease involved in a variety of physiological and pathological processes. Potent inhibitors against CTSL have long been sought for drug development. Due to insufficient specificity and suboptimal pharmacological properties for current CTSL inhibitors, novel agents are still required for selectively blocking ...
Xiaojing Shi, Yong Zhang
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The lysosomal protein cathepsin L is a progranulin protease
Molecular Neurodegeneration, 2017 Haploinsufficiency of GRN, the gene encoding progranulin (PGRN), causes frontotemporal lobar degeneration (FTLD), the second most common cause of early-onset dementia.
Chris W. Lee +12 more
semanticscholar +1 more source
Folia Histochemica et Cytobiologica, 2012 We studied the effect of heavy metal cations: Fe 2+, Cu2+, Zn2+, Cd2+, Hg2+, Pb2+ on the activity of<br />cathepsin D in human aorta homogenate and blood serum. The concentration of cations was 1 mmol/l.
Alicja Karwowska +5 more
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International Journal of Cardiology, 2019 The development of hypertension involves extensive arterial wall remodeling, in which cysteine proteases play an essential role. Cathepsin L/V has been reported to be a cysteine protease that is closely intertwined with the tissue inflammatory response ...
Yao Lu +6 more
semanticscholar +1 more source