Results 31 to 40 of about 108,127 (334)
Yeast as a tool to explore cathepsin D function [PDF]
, 2015 Cathepsin D has garnered increased attention in recent years, mainly since it has been associated with several human pathologies. In particular, cathepsin D is often overexpressed and hypersecreted in cancer cells, implying it may constitute a ...
Castro, L. +5 more
core +3 more sources
Respiratory Research, 2011 Background Remodeling of lung tissues during the process of granuloma formation requires significant restructuring of the extra-cellular matrix and cathepsins K, L and S are among the strongest extra-cellular matrix degrading enzymes.
Percival M David +3 more
doaj +1 more source
Peptide synthesis by recombinant Fasciola hepatica cathepsin L1 [PDF]
, 2006 Synthesis of the tripeptide Z-Phe-Arg-SerNH2 has been accomplished by a recombinant cysteine protease, cathepsin L1 from liver fluke (Fasciola hepatica), using Z-Phe-Arg-OMe as acyl acceptor and SerNH2 as nucleophile in 0.1 M ammonium acetate pH 9.0–12.5%
Ciarán Ó'Fágáin +16 more
core +1 more source
Human cathepsin L rescues the neurodegeneration and lethality in cathepsin B/L double-deficient mice [PDF]
Biological Chemistry, 2006 Abstract Cathepsin B (CTSB) and cathepsin L (CTSL) are two widely expressed cysteine proteases thought to predominantly reside within lysosomes. Functional analysis of CTSL in humans is complicated by the existence of two CTSL-like homologs (CTSL and CTSL2), in contrast to mice, which possess only one CTSL enzyme.
Sevenich, Lisa +3 more
openaire +4 more sources
Collagenolytic cysteine proteinases of bone tissue. Cathepsin B, (pro)cathepsin L and a cathepsin L-like 70 kDa proteinase [PDF]
Biochemical Journal, 1991 The aim of the work was to identify and characterize the cysteine proteinases of bone tissue, as these enzymes appear necessary for bone resorption. Three cysteine-dependent proteolytic activities were separated from a homogenate of mouse calvaria by a fractionation procedure involving (NH4)2SO4 precipitation, gel filtration and ion-exchange ...
J M, Delaissé, P, Ledent, G, Vaes
openaire +2 more sources
Indian Journal of Pathology and Microbiology, 2015 Background: Cysteine protease Cathepsin L is involved in bone remodeling and expressed in activated macrophages. It is highly expressed in metastatic tumor tissue, especially with bone metastases.
Bivas Biswas +3 more
doaj +1 more source
Cathepsin L plays a role in quinolinic acid-induced NF-Κb activation and excitotoxicity in rat striatal neurons. [PDF]
PLoS ONE, 2013 The present study seeks to investigate the role of cathepsin L in glutamate receptor-induced transcription factor nuclear factor-kappa B (NF-κB) activation and excitotoxicity in rats striatal neurons.
Yan-Ru Wang +6 more
doaj +1 more source
IGF-I receptor phosphorylation is impaired in cathepsin X-deficient prostate cancer cells [PDF]
, 2012 The cysteine-type peptidase cathepsin X is highly upregulated in several cancers and presumably promotes tumor invasion through bypassing cellular senescence. Here, we present first evidence that the underlying mechanism may involve the regulation of the
Bunsen, Thea +3 more
core +1 more source
A humanized antibody inhibitor for cathepsin L [PDF]
Protein Science, 2020 AbstractCathepsin L (CTSL) is a cysteine protease involved in a variety of physiological and pathological processes. Potent inhibitors against CTSL have long been sought for drug development. Due to insufficient specificity and suboptimal pharmacological properties for current CTSL inhibitors, novel agents are still required for selectively blocking ...
Xiaojing Shi, Yong Zhang
openaire +2 more sources
Folia Histochemica et Cytobiologica, 2012 We studied the effect of heavy metal cations: Fe 2+, Cu2+, Zn2+, Cd2+, Hg2+, Pb2+ on the activity of<br />cathepsin D in human aorta homogenate and blood serum. The concentration of cations was 1 mmol/l.
Alicja Karwowska +5 more
doaj +1 more source