Results 51 to 60 of about 16,299,323 (310)

Participation of cathepsin L on bone resorption [PDF]

FEBS Letters, 1993
The proteinase responsible for bone collagen degradation in osteo‐resorption was examined. The bone pit formation induced by parathyroid hormone (PTH) was markedly suppressed by leupeptin, E‐64 and cystatin A, while no inhibition was observed by CA‐074, a specific inhibitor of cathepsin B. Pig leucocyte cysteine proteinase inhibitor (PLCPI), a specific
Kakegawa, Hisao, Nikawa, Takeshi, Tagami, Kahori, Kamioka, Hiroshi, Sumitani, Koji, Kawata, Terushige, Drobnič-Kosorok, Marinka, Lenarčič, Brigita, Turk, Vito, Katunuma, Nobuhiko   +9 more
openaire   +2 more sources

Nuclear cathepsin L activity is required for cell cycle progression of colorectal carcinoma cells.

Biochimie, 2016
Prominent tasks of cysteine cathepsins involve endo-lysosomal proteolysis and turnover of extracellular matrix constituents or plasma membrane proteins for maintenance of intestinal homeostasis.
Tripti Tamhane, Rukshala Lllukkumbura, S. Lu, G. Maelandsmo, M. H. Haugen, K. Brix   +5 more
semanticscholar   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Analysis of the Proteolytic Processing of ABCA3: Identification of Cleavage Site and Involved Proteases. [PDF]

PLoS ONE, 2016
RATIONALE:ABCA3 is a lipid transporter in the limiting membrane of lamellar bodies in alveolar type II cells. Mutations in the ABCA3 gene cause respiratory distress syndrome in new-borns and childhood interstitial lung disease.
Nicole Hofmann, Dmitry Galetskiy, Daniela Rauch, Thomas Wittmann, Andreas Marquardt, Matthias Griese, Ralf Zarbock   +6 more
doaj   +1 more source

Combinatorial Synthesis of Next Generation Water‐Soluble Quaternized N‐Halamine Oligomers with Long‐Lasting Antiviral Properties

Advanced Functional Materials, EarlyView.
A combinatorial library of dual‐functional antiviral oligomers incorporating N‐halamine and quaternary ammonium functionalities is developed for long‐lasting antiviral activity. The lead materials exhibit rapid and durable antiviral activity against SARS‐CoV‐2 variants and influenza H1N1, with 4 to 5 log reduction in viral copies at 5 mg mL−1 ...
Eid Nassar‐Marjiya, Konda Reddy Kunduru, Krishanu Ghosal, Luna Rizik, Nofar Atari, Mahran Daifa, Neta Kutner, Bassma Khamaisi, Qi Wu, Simran Jindal, Merna Shaheen‐Mualim, Ranabir Majumder, Mahitosh Mandal, Michal Mandelboim, Shady Farah   +14 more
wiley   +1 more source

Cathepsin L Inactivates Human Trypsinogen, Whereas Cathepsin L-Deletion Reduces the Severity of Pancreatitis in Mice [PDF]

Gastroenterology, 2010
Acute pancreatitis is characterized by an activation cascade of digestive enzymes in the pancreas. The first of these, trypsinogen, can be converted to active trypsin by the peptidase cathepsin B (CTSB). We investigated whether cathepsin L (CTSL) can also process trypsinogen to active trypsin and has a role in pancreatitis.In CTSL-deficient (Ctsl(-/-))
Wartmann, Thomas, Mayerle, Julia, Kähne, Thilo, Sahin–Tóth, Miklós, Ruthenbürger, Manuel, Matthias, Rainer, Kruse, Anne, Reinheckel, Thomas, Peters, Christoph, Weiss, F. Ulrich, Sendler, Matthias, Lippert, Hans, Schulz, Hans-Ulrich, Aghdassi, Ali A., Dummer, Annegret, Teller, Steffen, Halangk, Walter, Lerch, Markus M.   +17 more
openaire   +3 more sources

Glycopeptide Antibiotics Potently Inhibit Cathepsin L in the Late Endosome/Lysosome and Block the Entry of Ebola Virus, Middle East Respiratory Syndrome Coronavirus (MERS-CoV), and Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV)

Journal of Biological Chemistry, 2016
Ebola virus infection can cause severe hemorrhagic fever with a high mortality in humans. The outbreaks of Ebola viruses in 2014 represented the most serious Ebola epidemics in history and greatly threatened public health worldwide.
Nan Zhou, T. Pan, Junsong Zhang, Qianwen Li, Xue Zhang, C. Bai, F. Huang, T. Peng, Jianhua Zhang, Chao Liu, L. Tao, Hui Zhang   +11 more
semanticscholar   +1 more source

Smart, Bio‐Inspired Polymers and Bio‐Based Molecules Modified by Zwitterionic Motifs to Design Next‐Generation Materials for Medical Applications

Advanced Functional Materials, EarlyView.
Bio‐based and (semi‐)synthetic zwitterion‐modified novel materials and fully synthetic next‐generation alternatives show the importance of material design for different biomedical applications. The zwitterionic character affects the physiochemical behavior of the material and deepens the understanding of chemical interaction mechanisms within the ...
Theresa M. Lutz, Jonas De Breuck, Sahar Salehi, Meike N. Leiske   +3 more
wiley   +1 more source

Cathepsin Y Expression is Up-Regulated in Liver and Spleen of the Rats Growing under a Low Protein Diet

Nutrition and Metabolic Insights, 2009
Background/Aims We have previously isolated a novel lysosomal cysteine protease, cathepsin Y, which produces a kinin-potenciating octapeptide from rat plasma.
Eri Nakazono, Takayoshi Yamaguchi, Keiko Yamafuji, Hiroko Tsuda   +3 more
doaj   +1 more source

Characterisation of a cysteine protease from poultry red mites and its potential use as a vaccine for chickens

Parasite, 2021
Poultry red mites (PRMs, Dermanyssus gallinae) are ectoparasites that negatively affect farmed chickens, leading to serious economic losses worldwide. Acaricides have been used to control PRMs in poultry houses.
Murata Shiro, Taniguchi Ayaka, Isezaki Masayoshi, Fujisawa Sotaro, Sakai Eishi, Taneno Akira, Ichii Osamu, Ito Takuya, Maekawa Naoya, Okagawa Tomohiro, Konnai Satoru, Ohashi Kazuhiko   +11 more
doaj   +1 more source