Results 51 to 60 of about 108,576 (328)
A Review of Small Molecule Inhibitors and Functional Probes of Human Cathepsin L
Molecules, 2020 Human cathepsin L belongs to the cathepsin family of proteolytic enzymes with primarily an endopeptidase activity. Although its primary functions were originally thought to be only of a housekeeping enzyme that degraded intracellular and endocytosed ...
Dibyendu Dana, Sanjai K. Pathak
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Cathepsin L plays a role in quinolinic acid-induced NF-Κb activation and excitotoxicity in rat striatal neurons. [PDF]
PLoS ONE, 2013 The present study seeks to investigate the role of cathepsin L in glutamate receptor-induced transcription factor nuclear factor-kappa B (NF-κB) activation and excitotoxicity in rats striatal neurons.
Yan-Ru Wang +6 more
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A bioavailable cathepsin S nitrile inhibitor abrogates tumor development [PDF]
, 2016 BACKGROUND: Cathepsin S has been implicated in a variety of malignancies with genetic ablation studies demonstrating a key role in tumor invasion and neo-angiogenesis.
Burden, Roberta E +4 more
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A humanized antibody inhibitor for cathepsin L [PDF]
Protein Science, 2020 AbstractCathepsin L (CTSL) is a cysteine protease involved in a variety of physiological and pathological processes. Potent inhibitors against CTSL have long been sought for drug development. Due to insufficient specificity and suboptimal pharmacological properties for current CTSL inhibitors, novel agents are still required for selectively blocking ...
Xiaojing Shi, Yong Zhang
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Folia Histochemica et Cytobiologica, 2012 We studied the effect of heavy metal cations: Fe 2+, Cu2+, Zn2+, Cd2+, Hg2+, Pb2+ on the activity of<br />cathepsin D in human aorta homogenate and blood serum. The concentration of cations was 1 mmol/l.
Alicja Karwowska +5 more
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Potential role of cytotoxic T-lymphocyte antigen 2 alpha in secretory activity of endocrine cells in mouse adenohypophysis [PDF]
Open Veterinary Journal, 2019 The peptide hormones of the adenohypophysis are produced by proteolytic processing of their prohormone precursors. Cathepsin L is known to function as a major proteolytic enzyme involved in the production of the peptide hormones.
Claudius Luziga
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A cardinal role for cathepsin D in co-ordinating the host-mediated apoptosis of macrophages and killing of pneumococci [PDF]
, 2011 The bactericidal function of macrophages against pneumococci is enhanced by their apoptotic demise, which is controlled by the anti-apoptotic protein Mcl-1.
Bewley, M.A. +10 more
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Molecular Cancer, 2010 Background Cathepsins represent a group of proteases involved in determining the metastatic potential of cancer cells. Among these are cysteinyl- (e.g. cathepsin B and cathepsin L) and aspartyl-proteases (e.g.
Matarrese Paola +9 more
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Cathepsin L in unstable plaques
Archives of Medical Science – Atherosclerotic Diseases, 2020 Bridging the gap between the pathogenesis of atherosclerosis, carotid plaques, and contributing to patient care is envisioned by incorporating bench research into technological interventions. Stroke is a massive public health problem, and in stroke care, immediate assessment and treatment are essential to reduce the risk of death and disability [1, 2].
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Cathepsin inhibition-induced lysosomal dysfunction enhances pancreatic beta-cell apoptosis in high glucose. [PDF]
PLoS ONE, 2015 Autophagy is a lysosomal degradative pathway that plays an important role in maintaining cellular homeostasis. We previously showed that the inhibition of autophagy causes pancreatic β-cell apoptosis, suggesting that autophagy is a protective mechanism ...
Minjeong Jung +4 more
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