Results 61 to 70 of about 108,127 (334)

Smart, Bio‐Inspired Polymers and Bio‐Based Molecules Modified by Zwitterionic Motifs to Design Next‐Generation Materials for Medical Applications

Advanced Functional Materials, EarlyView.
Bio‐based and (semi‐)synthetic zwitterion‐modified novel materials and fully synthetic next‐generation alternatives show the importance of material design for different biomedical applications. The zwitterionic character affects the physiochemical behavior of the material and deepens the understanding of chemical interaction mechanisms within the ...
Theresa M. Lutz, Jonas De Breuck, Sahar Salehi, Meike N. Leiske   +3 more
wiley   +1 more source

Cathepsin L Inactivates Human Trypsinogen, Whereas Cathepsin L-Deletion Reduces the Severity of Pancreatitis in Mice [PDF]

Gastroenterology, 2010
Acute pancreatitis is characterized by an activation cascade of digestive enzymes in the pancreas. The first of these, trypsinogen, can be converted to active trypsin by the peptidase cathepsin B (CTSB). We investigated whether cathepsin L (CTSL) can also process trypsinogen to active trypsin and has a role in pancreatitis.In CTSL-deficient (Ctsl(-/-))
Wartmann, Thomas, Mayerle, Julia, Kähne, Thilo, Sahin–Tóth, Miklós, Ruthenbürger, Manuel, Matthias, Rainer, Kruse, Anne, Reinheckel, Thomas, Peters, Christoph, Weiss, F. Ulrich, Sendler, Matthias, Lippert, Hans, Schulz, Hans-Ulrich, Aghdassi, Ali A., Dummer, Annegret, Teller, Steffen, Halangk, Walter, Lerch, Markus M.   +17 more
openaire   +3 more sources

Dual concentration-dependent activity of thyroglobulin type-1 domain of testican: specific inhibitor and substrate of cathepsin L [PDF]

, 2017
The thyroglobulin type-1 (Tg-1) domain is a protein module that occurs in a variety of secreted and membrane proteins and is recognised as a potent inhibitor of cysteine peptidases.
Baici, Antonio, Lenarčič, Brigita, Meh, Primož, Pavšič, Miha, Turk, Vito   +4 more
core  

Enhancing Magnetic Hyperthermia at the Cell Membrane by Anchoring 92R‐Functionalized Magnetic Nanoparticles to Low‐Endocytic CCR9 Surface Receptors

Advanced Healthcare Materials, EarlyView.
We present a strategy to enhance magnetic hyperthermia therapy by modulating nanoparticle–cell interactions. Antibody‐functionalized magnetic nanoparticles targeting the low‐internalizing CCR9 receptor enable spatially controlled membrane anchoring, reducing aggregation and maximizing heat generation under alternating magnetic fields.
David Egea‐Benavente, Isabel Corraliza‐Gorjón, Thomas S. van Zanten, María del Puerto Morales, Leonor Kremer, Domingo F. Barber   +5 more
wiley   +1 more source

The role of proteases in pathologies of the synovial joint [PDF]

, 2008
Synovial (diarthrodial) joints are employed within the body to provide skeletal mobility and have a characteristic structure adapted to provide a smooth almost frictionless surface for articulation.
Buttle, D, Jones, GC, Riley, GP
core   +1 more source

Bacteria‐Responsive Nanostructured Drug Delivery Systems for Targeted Antimicrobial Therapy

Advanced Materials, EarlyView.
Bacteria‐responsive nanocarriers are designed to release antimicrobials only in the presence of infection‐specific cues. This selective activation ensures drug release precisely at the site of infection, avoiding premature or indiscriminate release, and enhancing efficacy.
Guillermo Landa, Gracia Mendoza, Silvia Irusta, Manuel Arruebo   +3 more
wiley   +1 more source

Characterisation of a cysteine protease from poultry red mites and its potential use as a vaccine for chickens

Parasite, 2021
Poultry red mites (PRMs, Dermanyssus gallinae) are ectoparasites that negatively affect farmed chickens, leading to serious economic losses worldwide. Acaricides have been used to control PRMs in poultry houses.
Murata Shiro, Taniguchi Ayaka, Isezaki Masayoshi, Fujisawa Sotaro, Sakai Eishi, Taneno Akira, Ichii Osamu, Ito Takuya, Maekawa Naoya, Okagawa Tomohiro, Konnai Satoru, Ohashi Kazuhiko   +11 more
doaj   +1 more source

Fabrication, Properties, and Applications of Scaffolds for Bone Tissue Regeneration

Advanced Materials Technologies, EarlyView.
This review explores cutting‐edge biomaterials and fabrication techniques for scaffolds in bone tissue regeneration. It conducts a critical comparison of various strategies, meticulously analyzes the key contradictions in the field, and outlines an integrated development path spanning from biomaterial selection to clinical application, while ...
Shangsi Chen, Min Wang
wiley   +1 more source

Differential Regulation of Cathepsin S and Cathepsin L in Interferon γ–treated Macrophages [PDF]

The Journal of Experimental Medicine, 2003
Cathepsin S (catS) and cathepsin L (catL) mediate late stages of invariant chain (Ii) degradation in discrete antigen-presenting cell types. Macrophages (Mϕs) are unique in that they express both proteases and here we sought to determine the relative contribution of each enzyme.
Beers, Courtney, Honey, Karen, Fink, Susan, Forbush, Katherine, Rudensky, Alexander   +4 more
openaire   +2 more sources

Cysteine Cathepsins and Matrix Metalloproteases Among Breast Cancer Patients

Breast Cancer: Targets and Therapy, 2021
Solomon Tsegaye,1 Mohammed Mehdi,2 Wajana L Labisso,3 Daniel Seifu Melka2 1Department of Biochemistry, College of Health Sciences, Assela University, Addis Ababa, Ethiopia; 2Department of Biochemistry, College of Health Sciences, Addis Ababa University ...
Tsegaye S, Mehdi M, Lako WL, Melka DS
doaj