Results 151 to 160 of about 84,247 (372)

Gut microbiota‐related modulation of immune mechanisms in post‐infarction remodelling and heart failure

ESC Heart Failure, Volume 12, Issue 2, Page 942-954, April 2025.
Abstract The immune system has long been recognized as a key driver in the progression of heart failure (HF). However, clinical trials targeting immune effectors have consistently failed to improve patient outcome across different HF aetiologies. The activation of the immune system in HF is complex, involving a broad network of pro‐inflammatory and ...
Johann Roessler, Friederike Zimmermann, Bettina Heidecker, Ulf Landmesser, Arash Haghikia   +4 more
wiley   +1 more source

Relationship between cathepsins and cardiovascular diseases: a Mendelian randomized study

Frontiers in Pharmacology
Background: Cardiovascular diseases (CVDs) are the leading age-related disorders worldwide, with their prevalence increasing annually. Cathepsins are protein-degrading enzymes essential for processes such as intracellular protein breakdown, apoptosis ...
Qiaoqiao Li, Zhongzheng Zhou, Teng Xu, Xueping Gao, Yake Lou, Zijun Chen, Muzi Zhang, Qinghua Fang, Jie Tan, Jing Huang   +9 more
doaj   +1 more source

A two‐sample Mendelian randomization study and mediation analysis exploring the link between cathepsins and epilepsy

Epilepsia Open, EarlyView.
Abstract Objective This study aims to investigate the causal relationship between cathepsins and epilepsy, using Mendelian randomization (MR) and mediation analysis. Methods Publicly accessible summary statistics on epilepsy were obtained from FinnGen and the International League Against Epilepsy Consortium.
Huaiyu Sun, Di Ma, Wuqiong Zhang, Shuai Hou, Zhiqing Chen, Xuewei Li, Hongmei Meng, Daguang Zhang   +7 more
wiley   +1 more source

Cathepsin characterization from crude extract of yellow pike (Congresox talabon)

, 2019
Rizsa Mustika Pertiwi, I D Pamungkas, D T Prastyo, D U Trisdiani, E Pasaribu, ‪Tati Nurhayati   +5 more
openalex   +1 more source

Muscadine grape skin extract can antagonize Snail-cathepsin L-mediated invasion, migration and osteoclastogenesis in prostate and breast cancer cells [PDF]

, 2015
Liza J. Burton, Basil A. Smith, Bethany Smith, Quentin Loyd, Peri Nagappan, Danielle McKeithen, Catera L. Wilder, Manu O. Platt, Tamaro Hudson, Valerie Odero-Marah   +9 more
openalex   +1 more source

Dopamine D2 Receptor Signaling Attenuates Acinar Cell Necroptosis in Acute Pancreatitis through the Cathepsin B/TFAM/ROS Pathway [PDF]

, 2022
Zengkai Wu, Xiao Han, Jingpiao Bao, Bin Li, Jie Shen, Pengli Song, Qi Peng, Xingpeng Wang, Guoyong Hu   +8 more
openalex   +1 more source

Inconsistent Transcriptomic Responses to Hexabromocyclododecane in Japanese Quail: A Comparative Analysis of Results From Four Different Study Designs

Environmental Toxicology and Chemistry, EarlyView.
Abstract Efforts to use transcriptomics for toxicity testing have classically relied on the assumption that chemicals consistently produce characteristic transcriptomic signatures that are reflective of their mechanism of action. However, the degree to which transcriptomic responses are conserved across different test methodologies has seldom been ...
Paul Béziers, Elena Legrand, Emily Boulanger, Niladri Basu, Jessica D. Ewald, Paula Henry, Markus Hecker, Jianguo Xia, Natalie Karouna‐Renier, Doug Crump, Jessica Head   +10 more
wiley   +1 more source

Amino acid sequence of porcine spleen cathepsin D light chain.

, 1983
Takayuki Takahashi, Jordan Tang
openalex   +1 more source

Cardamonin Commands the Colonic Metabolite Columbianetin Acetate to Compete Against LPS in Binding HMGB1 in the Kidney, Preventing Lipopolysaccharide‐Induced Renal Tubular Pyroptosis

Food Frontiers, EarlyView.
Cardamonin upregulate sd the intestinal metabolite columbianetin acetate, which competitively bound HMGB1 to prevent LPS‐induced renal tubular cell pyroptosis (the figure is created with BioRender). ABSTRACT Sepsis‐associated acute kidney injury (SA‐AKI) results in high mortality due to the lack of effective interventions. The current study reports the
Zihui Zhou, Xuechun Sun, Jian Zhou, Huali Meng, Pengfei Fan, Yufeng Chu, Hao Wu   +6 more
wiley   +1 more source

Differential effects of non-steroidal anti-inflammatory agents on cathepsins D and E from rat spleen

, 1988
Kenji Yamamoto, Mitsue Takeda, Yuzo Kato
openalex   +1 more source