Results 181 to 190 of about 84,247 (372)

Piezo‐type mechanosensitive cation channel 1 in bone biomechanics and its multidimensional distribution characteristics in skeletal tissue

open access: yesVIEW, EarlyView.
PIEZO1 is highly correlated with mechanical stimulation, controlling bone growth and remodeling, while showing specific distribution characteristics under distinct loads. Upon dialectical review, this manuscript proposes that PIEZO1 could serve as a target for osteoporosis and a quantitative indicator for monitoring bone health in real‐time.
Chunyu Zhang, Yuehong Wang
wiley   +1 more source

Cathepsin-B inhibitor CA-074 attenuates retinopathy and optic neuritis in experimental autoimmune encephalomyelitis induced in SJL/J mice

open access: hybrid, 2022
Mohammad Rashid Khan   +7 more
openalex   +1 more source

Lack of Cathepsin D in the central nervous system results in microglia and astrocyte activation and the accumulation of proteinopathy-related proteins [PDF]

open access: gold, 2022
Chigure Suzuki   +7 more
openalex   +1 more source

Nanobody–chlorin e6 conjugate for Nectin‐4‐mediated tumor targeting and enhanced photodynamic therapy

open access: yesVIEW, EarlyView.
Nectin‐4 is frequently overexpressed in solid tumors, yet many PDT photosensitizers show poor water solubility and nonspecific uptake. A Nectin‐4‐targeted nanobody–chlorin e6 conjugate (NPC) improves aqueous solubility and selectively accumulates in Nectin‐4‐positive tumor cells.
Haodian Wan   +10 more
wiley   +1 more source

Live Imaging of Cysteine-Cathepsin Activity Reveals Dynamics of Focal Inflammation, Angiogenesis, and Polyp Growth

open access: gold, 2008
Elias Gounaris   +9 more
openalex   +2 more sources

L-leucyl-L-leucine methyl ester does not release cysteine cathepsins to the cytosol but inactivates them in transiently permeabilized lysosomes

open access: yesJournal of Cell Science, 2017
U. Repnik   +7 more
semanticscholar   +1 more source

Russian wheat aphid: a model for genomic plasticity and a challenge to breeders

open access: yesInsect Science, EarlyView.
Invasive foundress finds suitable habitat and reproduces through pathogenesis. Wingless females produce life offspring quickly, which leads to high population densities. High population densities result in competition, which may induce epigenetic changes and wing development for dispersal.
Astrid Jankielsohn   +8 more
wiley   +1 more source

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