Results 191 to 200 of about 20,584 (256)

NSAID ingestion augments training‐induced muscle hypertrophy and differentially affects muscle mRNA expression, but not strength gains, in trained men

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic outlining the impact of NSAID ingestion on resistance exercise training‐induced changes in muscle morphology, function and gene networks relative to placebo ingestion in trained males. Abstract Non‐steroidal anti‐inflammatory drugs (NSAIDs) are widely overused in sports.
Joanne E. Mallinson, Tariq Taylor, Dumitru Constantin‐Teodosiu, Despina Constantin, Martino V. Franchi, Dorothee Auer, Paul L. Greenhaff   +6 more
wiley   +1 more source

Lysosomal protease-mediated APP degradation is pH-dependent, mutation-sensitive, and facilitates tau proteolysis. [PDF]

Mol Neurodegener Adv
Ackley C, Liau Z, Arya S, Antee T, Cheang E, Knudsen GM, Lane-Donovan C, Sampognaro PJ, Kao AW.   +8 more
europepmc   +1 more source

Experimental models of cerebral small vessel disease: Physiological constraints, translational challenges and future directions

The Journal of Physiology, EarlyView.
Abstract figure legend Overview of cerebral small vessel disease (cSVD) pathophysiology and current modelling challenges. Left: clinical burden and key unresolved research questions. Right: neurovascular unit (NVU) architecture highlighting sites of cSVD pathology across arterioles, capillaries and venules, including interactions between endothelial ...
Sophie Beaumont, Tanya Singh, Luana Campos Soares, Mootaz M. Salman   +3 more
wiley   +1 more source

Targeting Glycolysis with 2-Deoxy-D-Glucose and Lysosomal Integrity with L-Leucyl-L-Leucine Methyl Ester as Antimelanoma Strategy. [PDF]

Pharmaceutics
Kosic M, Bosnjak M, Mandic M, Vucicevic L, Marjanovic MM, Poulsen SE, Harhaji-Trajkovic L.   +6 more
europepmc   +1 more source

Serine Protease Inhibitory Activity of Kampo Medicines: One of the Mechanisms Against Cold Syndrome

Traditional &Kampo Medicine, Volume 13, Issue 2, August 2026.
Serine protease inhibitory activity is involved in the mechanism of Kampo medicines used for treating common cold symptoms Ryokankyomishingeninto exhibited serine protease inhibitory activity in vitro and in vivo. Ryokankyomishingeninto showed anti‐SARS‐CoV‐2 activity in VeroE6/TMPRSS2 cells. ABSTRACT Aim Serine proteases play a key role in coronavirus
Yukiko Matsuo, Reina Akaiwa, Miku Yanagioka, Mishizu Kikuchi, Yuuna Kawahara, Takuma Yoshida, Hidemasa Nakaminami, Niro Inaba, Yoshihiro Mimaki   +8 more
wiley   +1 more source

Causal association between cathepsins and asthma: a Mendelian randomization study. [PDF]

Sci Rep
Qiu F, Shao W, Qin X, Xu R, Liu Y, Lu H.
europepmc   +1 more source

Unravelling the Significance of Cystatin C and Bunina Bodies in Amyotrophic Lateral Sclerosis Pathogenesis

Neuropathology and Applied Neurobiology, Volume 52, Issue 4, August 2026.
ABSTRACT Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease (MND), is a fatal neurodegenerative disease primarily affecting motor neurons. Two key protein inclusions found in lower motor neurons serve as neuropathological hallmarks of the disease in human tissue: the TDP43‐positive inclusion and the cystatin C‐positive Bunina body.
Sarah M. Granger, Rosemary A. Staniforth, Asbjorg Osk Snorradottir, Johnathan Cooper‐Knock, Kurt J. De Vos, J. Robin Highley   +5 more
wiley   +1 more source

Intralysosomal pathogens differentially influence the proteolytic potential of their niche. [PDF]

Infect Immun
Bird LE, Xu B, Thomas DR, McGowan ENS, Newton P, Scott NE, McConville MJ, Edgington-Mitchell LE, Newton HJ.   +8 more
europepmc   +1 more source

Contrast Agents for Enhanced Bioimaging: A Comprehensive Review

ChemBioChem, Volume 27, Issue 13, 14 July 2026.
Contrast agents, especially those that are nanoparticle‐based, are revolutionizing bioimaging by enabling highly sensitive, specific, and early‐stage diagnosis of diseases like cancer, using clinical imaging modalities such as CT, MRI, PET, and SPECT.
Paulo Sérgio Taube, Donald Fernandes, Arthur Abinader Vasconcelos, Hugo de Campos Braga, Alan Kelbis Oliveira Lima, José Arnaldo Santana Costa, Karla Furtado Andriani, Ester da Cunha Meira Santos, Antonio Jorge Silva Araújo Junior, Hauster Maximiler Campos de Paula, Wallace Júnio Reis, Kashif Gul, Nida Wahab, Luis Carlos Resio, Elisa Kawana Leal dos Santos, Márcio Peres de Araujo, Matheus Allen P. da Silva, Juliana Paula da Silva   +17 more
wiley   +1 more source

Cathepsin H increases the risk of diabetic retinopathy: evidence from Mendelian randomization and bioinformatic analysis. [PDF]

Diabetol Metab Syndr
Song X, Ma J, Zou T, Lu RX, Ji W, Huang F, Yin M.   +6 more
europepmc   +1 more source