Results 191 to 200 of about 51,705 (353)

Genomes of Fasciola hepatica from the Americas reveal colonization with Neorickettsia endobacteria related to the agents of Potomac horse and human Sennetsu fevers [PDF]

, 2017
Choi, Young-Jun, et al.,, Fischer, Peter U, Hallsworth-Pepin, Kymberlie, McNulty, Samantha N, Mitreva, Makedonka, Rosa, Bruce A, Tyagi, Rahul   +7 more
core   +1 more source

The Diagnostic Odyssey of a Biochemically Confirmed Case of ML II: The First Western Patient With LYSET Deficiency

Clinical Genetics, EarlyView.
We identify a female patient with a homozygous nonsense variant (p.Gln38Ter) in the LYSET gene. This is the first western report of a challenging case of an extensive diagnostic odyssey and demonstrates that the LYSET gene must be considered in the differential diagnosis when M6P‐labeled lysosomal enzymes are altered.
Fernanda Sperb‐Ludwig, Taciane Alegra, Leonardo Martinello da Rosa, Nataniel Floriano Ludwig, Renata Voltolini Velho, Ida Vanessa Doederlein Schwartz   +5 more
wiley   +1 more source

The protease cathepsin K can debulk the cancer glycocalyx. [PDF]

J Biol Chem
Kuo A, Tender GS, Chow WD, Riley NM, Wen KC, Park S, Paek JH, Roberts DS, Peltan EL, Paszek MJ, Bertozzi CR.   +10 more
europepmc   +1 more source

Hypoxia Exacerbates Periapical Periodontitis‐Associated Pathological Bone Loss via the Hypoxia‐Inducible Factor‐2α‐Calmodulin‐Dependent Protein Kinase IV Axis

Cell Proliferation, EarlyView.
Hypoxia exposure activates HIF‐2α, which binds to the Camk4 promoter to enhance RANKL‐mediated osteoclast differentiation, leading to aggravated alveolar bone resorption in periapical periodontitis. ABSTRACT Periapical periodontitis is one of the most common inflammatory bone destructive diseases. Epidemiological evidence suggests that hypoxia exposure,
Kang Gao, Yifan Xu, Haoran Du, Zixiao Li, Xiaochen Fang, Minghui Wang, Jia Liu, Xu Zha, Xianglong Han, Weihua Guo, Xicheng Liu, Jian Zhou   +11 more
wiley   +1 more source

It's a Trap!-Potential of Cathepsins in NET Formation. [PDF]

Int J Mol Sci
Pruchniak P, Niedzielska A, Nejfeld R, Wyżewski Z, Gregorczyk-Zboroch KP, Szulc-Dąbrowska L, Gieryńska M.   +6 more
europepmc   +1 more source

Estrogen receptor-Sp1 complexes mediate estrogen-induced cathepsin D gene expression in MCF-7 human breast cancer cells.

, 1994
Venkatesh Krishnan, Xiaofang Wang, Stephen Safe   +2 more
openalex   +1 more source

Cysteine proteinases and their inhibitors - A traditional topic of the Portoroz conferences [PDF]

, 2001
Fritz, H., Jochum, M.
core   +1 more source

CKAP4 Regulates ERS‐Induced Apoptosis in Osteoclasts Through FOXO3 in Periodontitis

Cell Proliferation, EarlyView.
CKAP4 promotes the transcription of PERK via FOXO3 in OCs, thereby facilitating ER stress‐induced apoptosis. In periodontitis, the reduction of CKAP4 in OCs leads to decreased OC apoptosis, which exacerbates alveolar bone resorption. ABSTRACT Periodontitis is a prevalent oral disease characterised by chronic inflammation and irreversible alveolar bone ...
Jiayu Cheng, Dihao Tao, Wenzhe Wang, Huiyu Wang, Hanzhe Wang, Yufan Liang, Jia Guo, Wenhao Liu, Yiming Wang, Jianhua Yang, Xiaoning He, Ce Shan, Bei Li   +12 more
wiley   +1 more source

Production of human cathepsins using Expi293™ mammalian cell expression system for off-target activity of cysteine protease inhibitor screening. [PDF]

Protein Sci
Turner Z, Arutyunova E, Bui DT, Han L, Kandadai AS, Bai B, Young HS, Mahal LK, Klassen JS, Lemieux MJ.   +9 more
europepmc   +1 more source

A Curcumin‐Derived HSP70 Inhibitor Disrupts Lysosomal Function to Suppress Triple‐Negative Breast Cancer Progression

Cell Proliferation, EarlyView.
Novel curcumin‐derived M4 binds HSP70's ATPase domain, disrupting HSP70‐mediated lysosomes‐autophagy pathway to inhibit TNBC growth and metastasis, and synergizes with paclitaxel for potent combination therapy. ABSTRACT Structural modification of curcumin yielded a novel series of 1,4‐pentadien‐3‐one oxime ether derivatives, among which compound M4 ...
Zijian Li, Wanxia Wang, Yuxin Zhou, Tao Zeng, Jian Liu, Yingjie Qing, Xuan Han   +6 more
wiley   +1 more source