Results 41 to 50 of about 623 (108)
Frontiers in EndocrinologyObjectivesThe relationship between cathepsins and prostate cancer (PCa) has been reported. However, there is a lack of research on cathepsins and benign prostate diseases (BPDs).
Hongliang Cao +10 more
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Journal of Dr. NTR University of Health Sciences, 2019 Cathepsins are a class of globular lysosomal proteases known to be responsible for protein degradation. In addition to proteolysis they have many biological roles such as apoptosis wound healing angiogenesis, proenzymatic activation, bone remodelling and
K Ajay Benarji +4 more
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Journal of Biological Chemistry, 1994 The primary specificity of papain-like proteinases is largely determined by S2-P2 site interactions. According to the three-dimensional structure of a papain-inhibitor complex, the S2 subsite is defined by residues 67, 68, 133, 157, 160, and 205, with residues 133, 157, and 205 integrated into the wall and bottom of the side chain binding cavity.
Dieter Brömme +3 more
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Cysteine cathepsins as regulators of the cytotoxicity of NK and T cells
Frontiers in Immunology, 2014 Cysteine cathepsins are lysosomal peptidases involved at different levels in the processes of the innate and adaptive immune responses. Some, such as cathepsins B, L and H are expressed constitutively in most immune cells.
Janko eKos +3 more
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Characterization of cathepsins in cartilage [PDF]
Biochemical Journal, 1967 The presence of a cathepsin B-like enzyme in rabbit ear cartilage was established by the use of the synthetic substrates benzoyl-l-arginine amide and benzoyl-dl-arginine 2-naphthylamide. This was facilitated by using a technique that permits the incubation of a fixed weight of thin (18μ) cartilage sections with an appropriate exogenous substrate.
E. Stainthorpe +3 more
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Biochemical Journal, 1980 Cathepsin H was purified from human liver by a method involving autolysis and acetone fractionation, and chromatography on DEAE-cellulose, Ultrogel AcA 54, hydroxyapatite and concanavalin A-Sepharose. The procedure allowed for the simultaneous isolation of cathepsin B and cathepsin D. Cathepsin H was shown to consist of a single polypeptide chain of 28
W N Schwartz, A J Barrett
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Comparative Analysis of Click Chemistry Mediated Activity-Based Protein Profiling in Cell Lysates
Molecules, 2013 Activity-based protein profiling uses chemical probes that covalently attach to active enzyme targets. Probes with conventional tags have disadvantages, such as limited cell permeability or steric hindrance around the reactive group.
Yinliang Yang +2 more
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HIV-1 envelope resistance to proteasomal cleavage: implications for vaccine induced immune responses. [PDF]
PLoS ONE, 2012 Antigen processing involves many proteolytic enzymes such as proteasomes and cathepsins. The processed antigen is then presented on the cell surface bound to either MHC class I or class II molecules and induces/interacts with antigen-specific CD8+ and ...
Nicholas J Steers +7 more
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Lysosomal cathepsins act in concert with Gasdermin-D during NAIP/NLRC4-dependent IL-1β secretion
Cell Death and Disease, 2022 The NAIP/NLRC4 inflammasome is classically associated with the detection of bacterial invasion to the cytosol. However, recent studies have demonstrated that NAIP/NLRC4 is also activated in non-bacterial infections, and in sterile inflammation. Moreover,
Laura Migliari Branco +8 more
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Folia Histochemica et Cytobiologica, 2012 The activity of cysteine peptidases (cathepsins B and L) was estimated in homogenates of tissues sampled during surgery from 60 patients operated due to colorectal tumors.
Julia Rudno-Rudzinska +7 more
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