Results 41 to 50 of about 84,247 (372)
Autophagy is activated and involved in cell death with participation of cathepsins during stress-induced microspore embryogenesis in barley [PDF]
, 2018 Microspores are reprogrammed towards embryogenesis by stress. Many microspores die after this stress, limiting the efficiency of microspore embryogenesis. Autophagy is a degradation pathway that plays critical roles in stress response and cell death.
Berenguer, Eduardo +4 more
core +1 more source
Expression of the elastolytic cathepsins S and K in human atheroma and regulation of their production in smooth muscle cells [PDF]
, 2014 Formation of the atherosclerotic intima must involve altered metabolism of the elastin-rich arterial extracellular matrix. Proteases potentially involved in these processes remain unclear.
Chapman, H A +4 more
core +1 more source
Biochemical Journal, 1980 Cathepsin H was purified from human liver by a method involving autolysis and acetone fractionation, and chromatography on DEAE-cellulose, Ultrogel AcA 54, hydroxyapatite and concanavalin A-Sepharose. The procedure allowed for the simultaneous isolation of cathepsin B and cathepsin D. Cathepsin H was shown to consist of a single polypeptide chain of 28
W N, Schwartz, A J, Barrett
openaire +2 more sources
Co-Emergence of Specialized Endothelial Cells from Embryonic Stem Cells. [PDF]
, 2018 A well-formed and robust vasculature is critical to the health of most organ systems in the body. However, the endothelial cells (ECs) forming the vasculature can exhibit a number of distinct functional subphenotypes like arterial or venous ECs, as well ...
Douglas, Simone A +6 more
core +1 more source
CD4+ Th immunogenicity of the Ascaris spp. secreted products [PDF]
, 2020 Ascaris spp. is a major health problem of humans and animals alike, and understanding the immunogenicity of its antigens is required for developing urgently needed vaccines.
Bertazzon, Miriam +6 more
core +1 more source
Urinary peptidomics analysis reveals proteases involved in diabetic nephropathy [PDF]
, 2017 Mechanisms underlying the onset and progression of nephropathy in diabetic patients are not fully elucidated. Deregulation of proteolytic systems is a known path leading to disease manifestation, therefore we hypothesized that proteases aberrantly ...
Bascands, Jean-Loup +15 more
core +2 more sources
Inhibition of MAPK-Erk pathway in vivo attenuates aortic valve disease processes in Emilin1-deficient mouse model [PDF]
, 2017 Aortic valve disease (AVD) is a common condition with a progressive natural history, and presently, there are no pharmacologic treatment strategies. Elastic fiber fragmentation (EFF) is a hallmark of AVD, and increasing evidence implicates developmental ...
Aikawa +45 more
core +2 more sources
Nature Communications, 2018 Metastatic lung cancer is the leading cause of cancer-associated mortality worldwide, therefore necessitating novel approaches to identify specific genetic drivers for lung cancer progression and metastasis.
S. Kundu +7 more
semanticscholar +1 more source
Determination of a predictive cleavage motif for eluted major histocompatibility complex class II ligands [PDF]
, 2018 CD4+ T cells have a major role in regulating immune responses. They are activated by recognition of peptides mostly generated from exogenous antigens through the major histocompatibility complex (MHC) class II pathway.
Dhanda, Sandeep Kumar +7 more
core +6 more sources
Frontiers in Immunology, 2022 The P2X7 receptor is a critical purinergic receptor in immune cells. Its activation was associated with cathepsin release into macrophage cytosol, suggesting its involvement in lysosomal membrane permeabilization (LMP) and leakage.
Stephanie Alexia Cristina Silva Santos +10 more
doaj +1 more source