Results 101 to 110 of about 3,347 (210)

Differential effects of cathinone compounds and MDMA on body temperature in the rat, and pharmacological characterization of mephedrone-induced hypothermia

, 2013
Background and PurposeRecreational users report that mephedrone has similar psychoactive effects to 3,4-methylenedioxymethamphetamine (MDMA). MDMA induces well-characterized changes in body temperature due to complex monoaminergic effects on central ...
Swift, K. M., Green, A. R., Fone, K. C.F., Shortall, S. E., King, M. V.   +4 more
core   +1 more source

Determination of Effective Functional Monomer and Solvent for R(+)-Cathinone Imprinted Polymer Using Density Functional Theory and Molecular Dynamics Simulation Approaches

Indonesian Journal of Chemistry, 2017
Determination of effective functional monomer and solvent for R(+)-cathinone imprinted polymer through modeling has been done using density functional theory (DFT) and molecular dynamics (MD) simulation approaches.
Andrian Saputra, Karna Wijaya, Ria Armunanto, Lisa Tania, Iqmal Tahir   +4 more
doaj   +1 more source

Expressed sequence tag analysis of khat (Catha edulis) provides a putative molecular biochemical basis for the biosynthesis of phenylpropylamino alkaloids

Genetics and Molecular Biology, 2011
Khat (Catha edulis Forsk.) is a flowering perennial shrub cultivated for its neurostimulant properties resulting mainly from the occurrence of (S)-cathinone in young leaves.
Jillian M. Hagel, Raz Krizevski, Korey Kilpatrick, Yaron Sitrit, Frédéric Marsolais, Efraim Lewinsohn, Peter J. Facchini   +6 more
doaj   +1 more source

Synthetic cathinone pharmacokinetics, analytical methods, and toxicological findings from human performance and postmortem cases

, 2016
Synthetic cathinones are commonly abused novel psychoactive substances (NPS). We present a comprehensive systematic review addressing in vitro and in vivo synthetic cathinone pharmacokinetics, analytical methods for detection and quantification in ...
Kayla N. Ellefsen (2812216), Marta Concheiro (672683), Marilyn A. Huestis (67663)   +2 more
core   +1 more source

MECHANISM OF ACTION OF (−)CATHINONE, A NEW ALKALOID FROM KHAT LEAVES [PDF]

, 2017
A new alkaloid, (−)cathinone, has recently been isolated from khat leaves and has been shown to induce amphetamine-like behavioural effects. The actions of this alkaloid at the cellular level are discussed here and it is concluded that (−)cathinone ...
KALIX, PETER
core  

Mechanism of action of cathinone: the active ingredient of khat (catha edulis)

, 2000
Objective: To review the current understanding of the mechanism of action of cathinone, the active ingredient of khat. Data source: Published experimental studies on the nature and action and effect of cathinone on the central nervous system both in ...
Patel, N.B.
core  

Comparative Assessment of the Addictive Potential of Synthetic Cathinones by Zebrafish Conditioned Place Preference (CPP) Paradigm

Life
Synthetic cathinones have gained increasing popularity in the illicit drug market, yet their abuse potential remains poorly understood. In this study, zebrafish were used to compare the addictive potential of three cathinone analogs, namely pentylone ...
Liao-Chen Chen, Ming-Huan Chan, Hwei-Hsien Chen   +2 more
doaj   +1 more source

Cathinone, active principle of the Khat leaf: Its effects on in vivo and in vitro lipolysis

, 1980
The effects of cathinone (active principle of Khat), on in vivo and in vitro lipolysis in rats have been studied. In vivo cathinone induces lipolytic activity, which is inhibited by reserpinization. In isolated adipocytes cathinone is devoid of intrinsic
NENCINI, Paolo
core  

Editorial: Old and new psychoactive substances: Pharmacology and potential applications

Frontiers in Psychiatry, 2023
Felix P. Mayer, Dino Luethi, Lorena B. Areal, Harald H. Sitte, Harald H. Sitte   +4 more
doaj   +1 more source

Simultaneous Quantitative Determination of Synthetic Cathinone Enantiomers in Urine and Plasma Using GC-NCI-MS

Journal of Analytical Methods in Chemistry, 2018
Development and validation of sensitive and selective method for enantioseparation and quantitation of synthetic cathinones is reported using GC-MS triple quadrupole mass spectrometry with negative chemical ionization (NCI) mode.
Rashed Alremeithi, Mohammed A. Meetani, Anas A. Alaidaros, Adnan Lanjawi, Khalid Alsumaiti   +4 more
doaj   +1 more source