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Stability of synthetic cathinones in blood and urine
Forensic Science International, 2019 Although there is an observed decline in the number of new psychoactive substances entering the drug market, this phenomenon is still a significant public health problem. Synthetic cathinones are the second largest group of new substances and currently belong to the most frequently confiscated.
Piotr Adamowicz
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Khat and synthetic cathinones: a review
Archives of Toxicology, 2013For centuries, 'khat sessions' have played a key role in the social and cultural traditions among several communities around Saudi Arabia and most East African countries. The identification of cathinone as the main psychoactive compound of khat leaves, exhibiting amphetamine-like pharmacological properties, resulted in the synthesis of several ...
Valente, Maria João +4 more
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Discriminative properties of l-cathinone compared to dl- and d-cathinone
Pharmacology Biochemistry and Behavior, 1986Rats were trained to discriminate between the stimulus properties of 0.6 mg/kg l-cathinone and its vehicle in a two-lever, food-motivated operant task. Once trained, rats showed a dose-dependent decrease in discrimination performance with lower l-cathinone doses and analysis of the dose-response relationship indicated an ED50 of 0.19 mg/kg ...
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Illicit cathinone (“Hagigat”) poisoning
Clinical Toxicology, 2008Khat leaves (mainly cathinone and cathine) have been chewed for centuries as stimulants. Hagigat (capsules of 200 mg cathinone) have been marketed in Israel as a natural stimulant and aphrodisiac. The consequences of illicit exposure to cathinone are reported.Prospective observational study of calls to the Poison Center regarding exposure to Hagigat ...
Yedidia, Bentur +2 more
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Mephedrone and other cathinones
Current Opinion in Psychiatry, 2014New designer drugs are constantly emerging in the illicit drug market and represent a significant health problem. A very popular class comprises synthetic cathinones, β-keto amphetamine analogues, endowed with psychostimulant properties. The aim of this review is to discuss the recent progress in our understanding of how cathinones act and the health ...
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Blood concentrations of synthetic cathinones
Clinical Toxicology, 2020Synthetic cathinones are the second most frequently seized group of new psychoactive substances. They are sold as replacements for controlled stimulants such as amphetamine, cocaine and MDMA. Synthetic cathinones are often determined in biological material collected from both living people and fatally intoxicated with these substances.
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Quantitative differences in the pharmacological effects of (+)- and (−)-cathinone
Experientia, 1985The optically pure isomers of cathinone were prepared by separating synthetic cathinone racemate and used to study central and peripheral effects of these indirect sympathomimetics in rats and guinea pigs. The (-)-isomer was significantly more potent than the (+)-isomer in stimulating locomotor activity whereas no difference was observed with respect ...
R, Gugelmann +3 more
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Potentiation of cathinone by caffeine and nikethamide
Pharmacology Biochemistry and Behavior, 1989The drug discrimination paradigm was employed to evaluate the effect of coadministration of both caffeine and nikethamide upon the discrimination of a low dose of cathinone. In rats trained to discriminate between 0.8 mg/kg l-cathinone and its vehicle in a two-lever food-motivated operant task, 0.2 mg/kg cathinone produced 29.2% of responses on the ...
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Forensic Science International, 2012
The first synthesis of the 2,3-isomers of MDPV, butylone and methylone is reported. The isomers were characterised by (1)H and (13)C NMR spectroscopy and compared to the corresponding 3,4-isomers. A GC method is described which separates the 3,4- and the 2,3-isomers from each other. IR spectra of the 2,3-isomers are also compared with the corresponding
Pierce, Kavanagh +6 more
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The first synthesis of the 2,3-isomers of MDPV, butylone and methylone is reported. The isomers were characterised by (1)H and (13)C NMR spectroscopy and compared to the corresponding 3,4-isomers. A GC method is described which separates the 3,4- and the 2,3-isomers from each other. IR spectra of the 2,3-isomers are also compared with the corresponding
Pierce, Kavanagh +6 more
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Toxicometabolomics of cathinone derivatives
2020Die vorliegende Arbeit untersuchte den Metabolismus der synthetischen Cathinone alpha-PBP, alpha-PVT, alpha-PHP, alpha-PEP, and alpha-POP mit und ohne Metabolomik. Der Metabolismus wurde konventionell untersucht, sowie die Kinetikparameter der beteiligten Cytochrom P450 (CYP) Enzyme bestimmt.
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